Addition of pioglitazone or bedtime insulin to maximal doses of sulfonylurea and metformin in type 2 diabetes patients with poor glucose control: a prospective, randomized trial

• Published in: The American journal of medicine Vol. 116; no. 4; pp. 230 - 235
• Main Authors: Aljabri, Khaled, Kozak, Sharon E, Thompson, David M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 15.02.2004; Elsevier; Elsevier Sequoia S.A
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Blood Glucose - drug effects; Blood Pressure - drug effects; Cholesterol - blood; Chromatography, High Pressure Liquid; Clinical outcomes; Diabetes; diabetes mellitus; Diabetes Mellitus, Type 2 - drug therapy; Drug therapy; Drug Therapy, Combination; Female; General aspects; Glycated Hemoglobin A - drug effects; Humans; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - therapeutic use; Insulin; Insulin - administration & dosage; Insulin - therapeutic use; Male; Medical research; Medical sciences; Metformin - administration & dosage; Metformin - therapeutic use; Middle Aged; pioglitazone; Sulfonylurea Compounds - administration & dosage; Sulfonylurea Compounds - therapeutic use; thiazolidinediones; Thiazolidinediones - administration & dosage; Thiazolidinediones - therapeutic use; Treatment Outcome; thiazolidinediones; pioglitazone; diabetes mellitus; insulin; Endocrinopathy; Type 2 diabetes; Human; Maximal dose; Pioglitazone; Thiazolidinedione derivatives; Glucose; Insulin; Medicine; Prospective; Hypoglycemic agent; Regulation(control); Biguanides; Sulfonylureas; Clinical trial; Metformin

To compare the efficacy of adding pioglitazone or bedtime isophane (NPH) insulin to maximal doses of metformin and an insulin secretagogue in patients with poor glucose control. We conducted a nonblinded, open-label, randomized controlled trial involving 62 patients with type 2 diabetes and glycosyl...