Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

• Published in: Journal of visualized experiments no. 95; p. e52216
• Main Authors: Limjunyawong, Nathachit, Fallica, Jonathan, Ramakrishnan, Amritha, Datta, Kausik, Gabrielson, Matthew, Horton, Maureen, Mitzner, Wayne
• Format: Journal Article
• Language: English
• Published: United States MyJove Corporation 06.01.2015
• Subjects: animal models; Animals; carbon monoxide; Female; fibrosis; fungi; gases; Genetics; humans; influenza; Lung Diseases - diagnosis; Lung Diseases - physiopathology; lung function; lungs; Male; Mice; Mice, Inbred C57BL; monitoring; Phenotype; Pulmonary Diffusing Capacity; pulmonary emphysema; pups; Respiratory Function Tests - methods

The mouse is now the primary animal used to model a variety of lung diseases. To study the mechanisms that underlie such pathologies, phenotypic methods are needed that can quantify the pathologic changes. Furthermore, to provide translational relevance to the mouse models, such measurements should...