Exploration of the Effect on Genome-Wide DNA Methylation by miR-143 Knock-Out in Mice Liver

• Published in: International journal of molecular sciences Vol. 22; no. 23; p. 13075
• Main Authors: Chen, Xingping, Luo, Junyi, Liu, Jie, Chen, Ting, Sun, Jiajie, Zhang, Yongliang, Xi, Qianyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.12.2021; MDPI
• Subjects: Animals; Apoptosis; Binding sites; Bioinformatics; Biomarkers; Cell growth; Computer science; CpG Islands; CRISPR; DNA Methylation; Epigenesis, Genetic; Epigenetics; Epigenomics; GC Rich Sequence; Gene expression; Genome; Genomes; High-Throughput Nucleotide Sequencing; Interdisciplinary subjects; Kinases; Liver - metabolism; Liver cancer; Liver diseases; Male; Mammals; Metabolism; Mice; Mice, Knockout; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Physiology; Promoter Regions, Genetic; Proteins; Quality control; Sulfites; Transgenic animals; Whole Genome Sequencing; DNA methylation; liver diseases; Whole-Genome Bisulfite Sequencing; miR-143

MiR-143 play an important role in hepatocellular carcinoma and liver fibrosis via inhibiting hepatoma cell proliferation. DNA methyltransferase 3 alpha (DNMT3a), as a target of miR-143, regulates the development of primary organic solid tumors through DNA methylation mechanisms. However, the effect...