Human pancreatic neuro-insular network in health and fatty infiltration

• Published in: Diabetologia Vol. 61; no. 1; pp. 168 - 181
• Main Authors: Tang, Shiue-Cheng, Baeyens, Luc, Shen, Chia-Ning, Peng, Shih-Jung, Chien, Hung-Jen, Scheel, David W., Chamberlain, Chester E., German, Michael S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2018; Springer Nature B.V
• Subjects: Adipocytes; Adipocytes - metabolism; Animals; Body Mass Index; Diabetes; Diabetes mellitus; Diabetes Mellitus, Type 2 - metabolism; Ganglia; Histology; Human Physiology; Humans; Innervation; Internal Medicine; Islet cells; Islets of Langerhans; Islets of Langerhans - metabolism; Medicine; Medicine & Public Health; Metabolic Diseases; Mice; Obesity; Obesity - metabolism; Pancreas; Pancreas - metabolism; Parasympathetic nervous system; Parenchyma; Sympathetic Nervous System - metabolism; Human islet; Sympathetic nerve; Type 2 diabetes; Adipocyte; Autonomic innervation; Obesity; Pancreatic ganglia; Fatty infiltration; BMI

Aims/hypothesis Identification of a pancreatic neuro-insular network in mice suggests that a similar integration of islets and nerves may be present in the human pancreas. To characterise the neuro-insular network and the intra-pancreatic ganglia in a clinically related setting, we examined human pa...