Resistance to rifampicin: a review

• Published in: Journal of antibiotics Vol. 67; no. 9; pp. 625 - 630
• Main Author: Goldstein, Beth P
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2014; Nature Publishing Group
• Subjects: 631/326/22/1290; Animals; Anti-Bacterial Agents - pharmacology; Bacteriology; Biomedical and Life Sciences; Bioorganic Chemistry; DNA-Directed RNA Polymerases - genetics; Drug Resistance, Bacterial - genetics; E coli; Escherichia coli - drug effects; Escherichia coli - genetics; Humans; Life Sciences; Medicinal Chemistry; Microbial Sensitivity Tests; Microbiology; Mutation; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - genetics; Organic Chemistry; review-article; Rifabutin - pharmacology; Rifampin - analogs & derivatives; Rifampin - pharmacology

Resistance to rifampicin (RIF) is a broad subject covering not just the mechanism of clinical resistance, nearly always due to a genetic change in the β subunit of bacterial RNA polymerase (RNAP), but also how studies of resistant polymerases have helped us understand the structure of the enzyme, th...