Adhesion- and Degranulation-Promoting Adapter Protein Is Required for Efficient Thymocyte Development and Selection
Adhesion- and degranulation-promoting adapter protein (ADAP) is required in TCR-induced activation and proliferation of peripheral T cells. Loss of ADAP also impairs TCR-initiated inside-out activation of the integrin LFA-1 (CD11a/CD18, alphaLbeta2). In this study, we demonstrate that ADAP-deficient...
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Published in | Journal of Immunology Vol. 176; no. 11; pp. 6681 - 6689 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Am Assoc Immnol
01.06.2006
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Subjects | |
Online Access | Get full text |
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