A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate
Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE) 1 . Follicular helper T cells (T FH cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibod...
Saved in:
| Published in | Nature medicine Vol. 25; no. 1; pp. 75 - 81 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.01.2019
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)
1
. Follicular helper T cells (T
FH
cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers
2
. Here, we describe a CXCR5
−
CXCR3
+
programmed death 1 (PD1)
hi
CD4
+
helper T cell population distinct from T
FH
cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4
+
T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand
3
. Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE.
A new population of T helper cells employs unique signals to support autoreactive B cells in patients with systemic lupus erythematosus. |
|---|---|
| AbstractList | Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)1. Follicular helper T cells (TFH cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers2. Here, we describe a CXCR5-CXCR3+ programmed death 1 (PD1)hiCD4+ helper T cell population distinct from TFH cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4+ T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand3. Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE. Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE) . Follicular helper T cells (T cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers . Here, we describe a CXCR5 CXCR3 programmed death 1 (PD1) CD4 helper T cell population distinct from T cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4 T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand . Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE. Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE)1. Follicular helper T cells (TFH cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers2. Here, we describe a CXCR5−CXCR3+ programmed death 1 (PD1)hiCD4+ helper T cell population distinct from TFH cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4+ T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand3. Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE. Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic lupus erythematosus (SLE) 1 . Follicular helper T cells (T FH cells) have long been implicated in SLE pathogenesis. Yet a fraction of autoantibodies in individuals with SLE are unmutated, supporting that autoreactive B cells also differentiate outside germinal centers 2 . Here, we describe a CXCR5 − CXCR3 + programmed death 1 (PD1) hi CD4 + helper T cell population distinct from T FH cells and expanded in both SLE blood and the tubulointerstitial areas of individuals with proliferative lupus nephritis. These cells produce interleukin-10 (IL-10) and accumulate mitochondrial reactive oxygen species as the result of reverse electron transport fueled by succinate. Furthermore, they provide B cell help, independently of IL-21, through IL-10 and succinate. Similar cells are generated in vitro upon priming naive CD4 + T cells with plasmacytoid dendritic cells activated with oxidized mitochondrial DNA, a distinct class of interferogenic toll-like receptor 9 ligand 3 . Targeting this pathway might blunt the initiation and/or perpetuation of extrafollicular humoral responses in SLE. A new population of T helper cells employs unique signals to support autoreactive B cells in patients with systemic lupus erythematosus. |
| Author | Xu, Zhaohui Veiga, Diogo Troggian Murat, Elise Stewart, Katie Nassi, Lorien Athale, Shruti Ucar, Duygu Baisch, Jeanine Walters, Lynnette Domic, Bojana Fuller, Julie Banchereau, Romain Chandra, Manjari Zhou, Joseph Caielli, Simone Wright, Tracey Punaro, Marilynn Ueno, Hideki Chung, Cheng-Han Banchereau, Jacques Pascual, Virginia Balasubramanian, Preetha |
| Author_xml | – sequence: 1 givenname: Simone surname: Caielli fullname: Caielli, Simone organization: Baylor Institute for Immunology Research, Drukier Institute for Children’s Health, Weill Cornell Medicine, Department of Pediatrics, Weill Cornell Medicine – sequence: 2 givenname: Diogo Troggian surname: Veiga fullname: Veiga, Diogo Troggian organization: The Jackson Laboratory for Genomic Medicine – sequence: 3 givenname: Preetha surname: Balasubramanian fullname: Balasubramanian, Preetha organization: Drukier Institute for Children’s Health, Weill Cornell Medicine, Department of Pediatrics, Weill Cornell Medicine – sequence: 4 givenname: Shruti surname: Athale fullname: Athale, Shruti organization: Baylor Institute for Immunology Research – sequence: 5 givenname: Bojana surname: Domic fullname: Domic, Bojana organization: Baylor Institute for Immunology Research – sequence: 6 givenname: Elise surname: Murat fullname: Murat, Elise organization: Baylor Institute for Immunology Research, Drukier Institute for Children’s Health, Weill Cornell Medicine, Department of Pediatrics, Weill Cornell Medicine – sequence: 7 givenname: Romain orcidid: 0000-0001-6916-6445 surname: Banchereau fullname: Banchereau, Romain organization: Baylor Institute for Immunology Research – sequence: 8 givenname: Zhaohui surname: Xu fullname: Xu, Zhaohui organization: Baylor Institute for Immunology Research – sequence: 9 givenname: Manjari surname: Chandra fullname: Chandra, Manjari organization: Baylor Institute for Immunology Research – sequence: 10 givenname: Cheng-Han surname: Chung fullname: Chung, Cheng-Han organization: The Jackson Laboratory for Genomic Medicine – sequence: 11 givenname: Lynnette surname: Walters fullname: Walters, Lynnette organization: Baylor Institute for Immunology Research, Texas Scottish Rite Hospital for Children – sequence: 12 givenname: Jeanine surname: Baisch fullname: Baisch, Jeanine organization: Baylor Institute for Immunology Research, Drukier Institute for Children’s Health, Weill Cornell Medicine, Department of Pediatrics, Weill Cornell Medicine – sequence: 13 givenname: Tracey surname: Wright fullname: Wright, Tracey organization: Texas Scottish Rite Hospital for Children, Department of Pediatrics, University of Texas Southwestern Medical Center – sequence: 14 givenname: Marilynn surname: Punaro fullname: Punaro, Marilynn organization: Texas Scottish Rite Hospital for Children, Department of Pediatrics, University of Texas Southwestern Medical Center – sequence: 15 givenname: Lorien surname: Nassi fullname: Nassi, Lorien organization: Texas Scottish Rite Hospital for Children, Department of Pediatrics, University of Texas Southwestern Medical Center – sequence: 16 givenname: Katie surname: Stewart fullname: Stewart, Katie organization: Texas Scottish Rite Hospital for Children, Department of Pediatrics, University of Texas Southwestern Medical Center – sequence: 17 givenname: Julie surname: Fuller fullname: Fuller, Julie organization: Texas Scottish Rite Hospital for Children, Department of Pediatrics, University of Texas Southwestern Medical Center – sequence: 18 givenname: Duygu orcidid: 0000-0002-9772-3066 surname: Ucar fullname: Ucar, Duygu organization: The Jackson Laboratory for Genomic Medicine – sequence: 19 givenname: Hideki orcidid: 0000-0002-7128-3816 surname: Ueno fullname: Ueno, Hideki organization: Baylor Institute for Immunology Research, Mount Sinai School of Medicine – sequence: 20 givenname: Joseph surname: Zhou fullname: Zhou, Joseph organization: Pathologists Bio-Medical Laboratories – sequence: 21 givenname: Jacques orcidid: 0000-0003-3535-7221 surname: Banchereau fullname: Banchereau, Jacques organization: The Jackson Laboratory for Genomic Medicine – sequence: 22 givenname: Virginia orcidid: 0000-0002-8806-8426 surname: Pascual fullname: Pascual, Virginia email: vip2021@med.cornell.edu organization: Baylor Institute for Immunology Research, Drukier Institute for Children’s Health, Weill Cornell Medicine, Department of Pediatrics, Weill Cornell Medicine, Texas Scottish Rite Hospital for Children |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30478422$$D View this record in MEDLINE/PubMed |
| BookMark | eNp1kUtr3TAQhUVJaR7ND-imCLoJBLWSLNnSMr15NBDIJoXshGyNc33rK7mSVdJ_H906bSGQ1QjmmzNndA7Rng8eEPrA6GdGK_UlCSY1I5QpQrkURL9BB0yKmrCG3u-VN20UUVrW--gwpQ2ltKJSv0P7FRWNEpwfoM0ZXp2LU3yHOxhHPIUpj3YegsfwOFnvwOHB4zFPOeF2DMHhKYZfg4OEvy4jaxgnPK9jyA_rws4QR8g_Bk8YxUUAp9x1g7czvEdvezsmOH6uR-j75cXd6hu5ub26Xp3dkK6cMxMnRK1bqlnXAasc753VrWWO9RyEbKVrtJCu_1N61oFQrldOOamUdZSr6gidLLrF6c8MaTbbIe2sWg8hJ8NZpWqhNNcF_fQC3YQcfXFXqFrIqlENLRRbqC6GlCL0ZorD1sbfhlGzC8IsQZgShNkFYXbKH5-Vc7sF92_i788XgC9AKi3_APH_6tdVnwDfjJR_ |
| CitedBy_id | crossref_primary_10_1093_rheumatology_kez228 crossref_primary_10_1016_j_jaci_2021_06_023 crossref_primary_10_1172_jci_insight_130062 crossref_primary_10_1016_j_coi_2019_06_005 crossref_primary_10_1002_art_41987 crossref_primary_10_3389_fimmu_2019_01601 crossref_primary_10_1016_j_smim_2022_101653 crossref_primary_10_3389_fimmu_2021_676082 crossref_primary_10_3389_fnut_2024_1364841 crossref_primary_10_1177_09612033211073909 crossref_primary_10_1093_rheumatology_keaa417 crossref_primary_10_1097_BOR_0000000000000685 crossref_primary_10_1101_gr_265249_120 crossref_primary_10_3390_ijms24010365 crossref_primary_10_4049_jimmunol_2200953 crossref_primary_10_3389_fimmu_2023_1155421 crossref_primary_10_1016_j_xpro_2024_103119 crossref_primary_10_2139_ssrn_4113517 crossref_primary_10_1002_eji_201948320 crossref_primary_10_3390_ijms242015234 crossref_primary_10_1002_art_42446 crossref_primary_10_1007_s10875_020_00771_0 crossref_primary_10_1093_micmic_ozac046 crossref_primary_10_3389_fimmu_2023_1145573 crossref_primary_10_3389_fimmu_2023_1257321 crossref_primary_10_1007_s12098_023_04815_2 crossref_primary_10_1016_j_immuni_2019_03_020 crossref_primary_10_1111_jcmm_14832 crossref_primary_10_1016_j_jaut_2024_103218 crossref_primary_10_1038_s41584_018_0150_1 crossref_primary_10_1182_blood_2022016581 crossref_primary_10_1111_imr_12847 crossref_primary_10_1089_ars_2021_0073 crossref_primary_10_1186_s12929_024_01024_7 crossref_primary_10_3389_fimmu_2023_1178792 crossref_primary_10_1002_rai2_12114 crossref_primary_10_1136_annrheumdis_2019_215597 crossref_primary_10_1097_CM9_0000000000000983 crossref_primary_10_1111_febs_15312 crossref_primary_10_2478_ahem_2022_0038 crossref_primary_10_1016_j_clim_2020_108445 crossref_primary_10_1093_mr_roab023 crossref_primary_10_1007_s12016_022_08936_y crossref_primary_10_2174_1871530323666230915112642 crossref_primary_10_1002_art_41687 crossref_primary_10_1002_art_42776 crossref_primary_10_3389_fimmu_2022_1125497 crossref_primary_10_1016_j_omtn_2021_02_028 crossref_primary_10_1016_j_celrep_2022_111193 crossref_primary_10_1002_iub_2558 crossref_primary_10_1016_j_isci_2023_106774 crossref_primary_10_1093_intimm_dxac032 crossref_primary_10_26508_lsa_202000766 crossref_primary_10_1016_j_celrep_2020_108424 crossref_primary_10_1002_eji_202149279 crossref_primary_10_1111_sji_13192 crossref_primary_10_1016_j_molcel_2020_04_002 crossref_primary_10_3389_fimmu_2024_1288234 crossref_primary_10_1002_acr2_11343 crossref_primary_10_1002_pro6_1193 crossref_primary_10_12688_wellcomeopenres_16883_1 crossref_primary_10_12688_wellcomeopenres_16883_2 crossref_primary_10_1111_1756_185X_14170 crossref_primary_10_1172_JCI127949 crossref_primary_10_3390_cancers14061452 crossref_primary_10_1002_advs_202102778 crossref_primary_10_3389_fmed_2022_849120 crossref_primary_10_7759_cureus_63875 crossref_primary_10_1111_all_15764 crossref_primary_10_1111_jcmm_16438 crossref_primary_10_1093_rheumatology_kez276 crossref_primary_10_1016_j_jhep_2020_05_053 crossref_primary_10_1038_s41581_018_0096_1 crossref_primary_10_1038_s41467_024_46053_w crossref_primary_10_1038_s41401_021_00773_7 crossref_primary_10_1002_acr2_11296 crossref_primary_10_3389_fimmu_2020_581385 crossref_primary_10_3390_antiox12010181 crossref_primary_10_1002_art_42383 crossref_primary_10_1016_j_yjmcc_2022_06_010 crossref_primary_10_1016_j_it_2021_06_003 crossref_primary_10_1111_imr_13360 crossref_primary_10_1073_pnas_2217902120 crossref_primary_10_1093_rheumatology_keac112 crossref_primary_10_1111_cei_13277 crossref_primary_10_3892_etm_2022_11579 crossref_primary_10_1038_s41590_024_01887_w crossref_primary_10_1126_scitranslmed_aay1620 crossref_primary_10_1016_j_healun_2021_03_007 crossref_primary_10_1016_j_jaut_2022_102856 crossref_primary_10_3389_fimmu_2019_01487 crossref_primary_10_18632_aging_103566 crossref_primary_10_1038_s41590_020_0677_6 crossref_primary_10_1016_j_jaci_2020_05_022 crossref_primary_10_1097_BOR_0000000000000644 crossref_primary_10_1136_lupus_2020_000437 crossref_primary_10_1146_annurev_immunol_101921_042422 crossref_primary_10_1096_fj_202301796R crossref_primary_10_3390_ijms22031347 crossref_primary_10_1016_j_celrep_2022_110565 crossref_primary_10_1038_s41584_019_0254_2 crossref_primary_10_2139_ssrn_3992090 crossref_primary_10_1016_j_phrs_2023_106997 crossref_primary_10_1002_eji_202250109 crossref_primary_10_3389_fimmu_2020_593103 crossref_primary_10_1093_intimm_dxac026 crossref_primary_10_1093_eurheartj_ehab605 crossref_primary_10_2147_JIR_S331188 crossref_primary_10_1038_s42003_024_05989_x crossref_primary_10_1093_intimm_dxaa006 crossref_primary_10_3389_fimmu_2021_633845 crossref_primary_10_1016_j_bbadis_2024_167303 crossref_primary_10_3389_fimmu_2022_855812 crossref_primary_10_1016_j_clim_2023_109239 crossref_primary_10_1016_j_it_2020_11_004 crossref_primary_10_1097_BOR_0000000000000777 crossref_primary_10_1016_j_coi_2019_07_001 crossref_primary_10_1186_s12974_021_02375_w crossref_primary_10_1097_BOR_0000000000000775 crossref_primary_10_3390_ijms232213928 crossref_primary_10_1016_j_celrep_2024_114370 crossref_primary_10_1002_eji_201948134 crossref_primary_10_1016_j_smim_2019_101322 crossref_primary_10_1016_j_smim_2019_101330 crossref_primary_10_3390_cells8020140 crossref_primary_10_1007_s10238_023_01289_6 crossref_primary_10_1002_cti2_1427 crossref_primary_10_1016_j_crmeth_2022_100224 crossref_primary_10_1016_j_heliyon_2024_e27687 crossref_primary_10_1016_j_cmet_2021_08_008 crossref_primary_10_1172_JCI141054 crossref_primary_10_1016_j_immuni_2020_04_015 crossref_primary_10_3389_fimmu_2022_1032575 crossref_primary_10_3389_fimmu_2022_843192 crossref_primary_10_1016_j_imlet_2023_06_005 crossref_primary_10_1016_j_jaut_2022_102870 crossref_primary_10_3389_fimmu_2021_641886 crossref_primary_10_3389_fimmu_2022_970906 crossref_primary_10_1172_JCI146071 crossref_primary_10_3389_fimmu_2020_616832 crossref_primary_10_3389_fimmu_2019_02918 crossref_primary_10_1016_j_coi_2019_09_004 crossref_primary_10_1097_MOG_0000000000000704 crossref_primary_10_1038_s41584_022_00834_z crossref_primary_10_1073_pnas_1917834117 crossref_primary_10_14405_kjvr_2021_61_e1 crossref_primary_10_7554_eLife_53226 crossref_primary_10_1016_j_jaut_2022_102989 crossref_primary_10_1038_s41584_020_0500_7 crossref_primary_10_1073_pnas_2108376118 crossref_primary_10_1016_j_ccmp_2021_100011 crossref_primary_10_1016_j_jfma_2022_05_003 crossref_primary_10_1038_s41467_023_36522_z crossref_primary_10_1093_hmg_ddaa131 crossref_primary_10_1186_s12967_024_05262_z crossref_primary_10_1038_s41590_021_00901_9 crossref_primary_10_1093_rheumatology_kez077 crossref_primary_10_1016_j_mce_2022_111812 crossref_primary_10_1186_s42358_023_00333_z crossref_primary_10_1038_s41584_019_0241_7 crossref_primary_10_1080_1744666X_2021_1976146 crossref_primary_10_1038_s41586_022_04642_z crossref_primary_10_1093_oxfimm_iqad005 crossref_primary_10_1126_sciimmunol_adk1643 crossref_primary_10_1016_j_celrep_2022_111606 crossref_primary_10_1134_S1990747821060040 crossref_primary_10_1172_JCI132249 crossref_primary_10_1016_j_jaci_2022_09_018 crossref_primary_10_1007_s11010_019_03667_9 crossref_primary_10_1016_j_cell_2021_07_021 crossref_primary_10_1038_s41423_020_00529_z |
| Cites_doi | 10.1016/S0198-8859(02)00753-X 10.1084/jem.20151159 10.1002/art.1780400928 10.1084/jem.182.5.1265 10.1146/annurev.immunol.19.1.683 10.1084/jem.20061660 10.4049/jimmunol.167.4.2361 10.1038/nmeth.2688 10.1038/labinvest.3780210 10.1016/j.immuni.2010.12.012 10.1093/bioinformatics/btv145 10.1259/bjr/54004230 10.1038/nature09102 10.1007/s11926-016-0622-8 10.1016/j.immuni.2012.10.020 10.1182/blood-2011-01-331462 10.1002/art.20745 10.4049/jimmunol.1001983 10.1038/ni1467 10.1038/ni.2947 10.1038/ki.2010.333 10.1111/j.1523-1755.2004.00443.x 10.1038/ni.3175 10.1016/j.tcb.2013.11.008 10.1056/NEJMra1100359 10.1016/j.celrep.2016.03.009 10.1038/nature11986 10.1093/bioinformatics/btp324 10.1093/bioinformatics/btu170 10.4049/jimmunol.167.4.1862 10.1038/ni.3054 10.1146/annurev.immunol.26.021607.090331 10.1046/j.1365-2567.2002.01457.x 10.1172/JCI23025 10.1038/nri2358 10.1042/BJ20081386 10.1073/pnas.89.5.1890 10.1038/s41467-018-03750-7 10.1038/nprot.2014.018 10.1016/S1074-7613(03)00208-5 10.1038/nature20810 10.1016/j.molcel.2010.05.004 10.1084/jem.20151876 10.1016/j.immuni.2013.08.031 10.1084/jem.185.6.1101 10.1191/0961203304lu1014oa 10.1101/gad.14.14.1693 10.1126/sciimmunol.aan8664 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature America, Inc. 2018 Copyright Nature Publishing Group Jan 2019 |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature America, Inc. 2018 – notice: Copyright Nature Publishing Group Jan 2019 |
| DBID | CGR CUY CVF ECM EIF NPM AAYXX CITATION 3V. 7QG 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U7 7U9 7X7 7XB 88A 88E 88I 8AO 8FD 8FE 8FH 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BBNVY BENPR BHPHI C1K CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ GUQSH H94 HCIFZ K9. LK8 M0S M1P M2O M2P M7N M7P MBDVC P64 PQEST PQQKQ PQUKI Q9U RC3 7X8 |
| DOI | 10.1038/s41591-018-0254-9 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Immunology Abstracts Neurosciences Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Toxicology Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) Science Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Research Library (Alumni Edition) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Community College ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) Research Library Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Research Library (Corporate) Biotechnology and BioEngineering Abstracts ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central Basic Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Research Library Prep ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management Health Research Premium Collection Natural Science Collection Biological Science Collection Chemoreception Abstracts ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts Technology Research Database ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College Research Library (Alumni Edition) ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Biology Journals (Alumni Edition) ProQuest Central Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts ProQuest Research Library ProQuest Central Basic Toxicology Abstracts ProQuest Science Journals ProQuest SciTech Collection ProQuest Medical Library Animal Behavior Abstracts Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE Research Library Prep |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1546-170X |
| EndPage | 81 |
| ExternalDocumentID | 10_1038_s41591_018_0254_9 30478422 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NIAMS NIH HHS grantid: P50 AR070594 – fundername: NIAID NIH HHS grantid: U19 AI082715 – fundername: NIAMS NIH HHS grantid: P50 AR054083 |
| GroupedDBID | --- .-4 .55 .GJ 0R~ 123 1CY 29M 2FS 36B 39C 3O- 3V. 4.4 53G 5BI 5M7 5RE 5S5 70F 7X7 85S 88A 88E 88I 8AO 8FE 8FH 8FI 8FJ 8G5 8R4 8R5 AAEEF AARCD AAYOK AAZLF ABAWZ ABCQX ABDBF ABEFU ABJNI ABLJU ABOCM ABUWG ABVXF ACGFO ACGFS ACGOD ACIWK ACMJI ACPRK ADBBV ADFRT AENEX AFBBN AFKRA AFRAH AFSHS AGAYW AGCDD AGEZK AGHTU AHBCP AHMBA AHOSX AHSBF AIBTJ ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH ARMCB ASPBG AVWKF AXYYD AZFZN AZQEC B0M BBNVY BENPR BHPHI BKKNO BPHCQ BVXVI CCPQU CS3 DB5 DU5 DWQXO EAD EAP EBC EBD EBS EE. EJD EMB EMK EMOBN EPL ESX EXGXG F5P FEDTE FQGFK FSGXE FYUFA G8K GNUQQ GUQSH GX1 HCIFZ HMCUK HVGLF HZ~ IAO IEA IH2 IHR IHW INH INR IOF IOV ISR ITC J5H L7B LGEZI LK8 LOTEE M0L M1P M2O M2P M7P MK0 N9A NADUK NNMJJ NXXTH O9- ODYON P2P PQQKQ PROAC PSQYO Q2X RIG RNS RNT RNTTT RVV SHXYY SIXXV SJN SNYQT SV3 TAE TAOOD TBHMF TDRGL TSG TUS UKHRP UQL X7M XJT YHZ ZGI ~8M AAYZH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QG 7QL 7QP 7QR 7T5 7TK 7TM 7TO 7U7 7U9 7XB 8FD 8FK C1K FR3 H94 K9. M7N MBDVC P64 PQEST PQUKI Q9U RC3 7X8 |
| ID | FETCH-LOGICAL-c415t-d4469b091cce13d2fda9ba1d1f2e45b5d7945dfd7945f1ce48df8d8d588ad0283 |
| IEDL.DBID | BENPR |
| ISSN | 1078-8956 |
| IngestDate | Sat Oct 05 05:35:37 EDT 2024 Thu Oct 10 21:02:08 EDT 2024 Thu Sep 12 16:46:13 EDT 2024 Fri Oct 18 09:17:08 EDT 2024 Fri Oct 11 20:44:46 EDT 2024 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c415t-d4469b091cce13d2fda9ba1d1f2e45b5d7945dfd7945f1ce48df8d8d588ad0283 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-6916-6445 0000-0002-9772-3066 0000-0002-8806-8426 0000-0002-7128-3816 0000-0003-3535-7221 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325012 |
| PMID | 30478422 |
| PQID | 2164537870 |
| PQPubID | 33975 |
| PageCount | 7 |
| ParticipantIDs | proquest_miscellaneous_2138648929 proquest_journals_2164537870 crossref_primary_10_1038_s41591_018_0254_9 pubmed_primary_30478422 springer_journals_10_1038_s41591_018_0254_9 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Nature medicine |
| PublicationTitleAbbrev | Nat Med |
| PublicationTitleAlternate | Nat Med |
| PublicationYear | 2019 |
| Publisher | Nature Publishing Group US Nature Publishing Group |
| Publisher_xml | – name: Nature Publishing Group US – name: Nature Publishing Group |
| References | Bolger, Lohse, Usadel (CR44) 2014; 30 Arce (CR31) 2001; 167 Rousset (CR21) 1992; 89 Caielli (CR3) 2016; 213 Penna, Sozzani, Adorini (CR11) 2001; 167 Jackson, DeLoose, Gilbert (CR14) 2002; 106 Oaks, Winans, Huang, Banki, Perl (CR20) 2016; 18 Tsokos (CR1) 2011; 365 Schmitt (CR42) 2014; 15 Garrone (CR43) 1995; 182 Ito (CR8) 2007; 204 Locci (CR27) 2013; 39 Hochberg (CR40) 1997; 40 Tipton (CR2) 2015; 16 Keir, Butte, Freeman, Sharpe (CR26) 2008; 26 Guiducci (CR4) 2010; 465 Chang (CR36) 2011; 186 Wang (CR34) 2018; 9 Gilliet, Liu (CR6) 2002; 63 Rubtsov (CR33) 2011; 118 Li, Durbin (CR45) 2009; 25 Jego (CR7) 2003; 19 Grouard (CR10) 1997; 185 Mills, O’Neill (CR24) 2014; 24 Glimcher, Murphy (CR12) 2000; 14 Buenrostro, Giresi, Zaba, Chang, Greenleaf (CR30) 2013; 10 Blanco (CR35) 2005; 52 Means (CR5) 2005; 115 Tannahill (CR19) 2013; 496 Gilliet, Cao, Liu (CR9) 2008; 8 Salabei, Gibb, Hill (CR48) 2014; 9 Morita (CR28) 2011; 34 Heinz (CR47) 2010; 38 Guaras (CR17) 2016; 15 CR29 Anoopkumar-Dukie (CR41) 2005; 78 Rao (CR37) 2017; 542 Dorner, Lipsky (CR32) 2004; 13 Murphy (CR18) 2009; 417 Peti-Peterdi (CR38) 2010; 78 Acosta-Rodriguez (CR13) 2007; 8 Moore, de Waal Malefyt, Coffman, O’Garra (CR22) 2001; 19 Yu, Wang, He (CR46) 2015; 31 Nag, Picard, Stewart (CR16) 2001; 81 Buck, O’Sullivan, Pearce (CR25) 2015; 212 Sena (CR15) 2013; 38 Weening (CR39) 2004; 65 Ueno, Banchereau, Vinuesa (CR23) 2015; 16 30552381 - Nat Rev Rheumatol. 2019 Feb;15(2):63. doi: 10.1038/s41584-018-0150-1 31088799 - Ann Rheum Dis. 2019 Jun;78(6):e59. doi: 10.1136/annrheumdis-2019-215597 C Guiducci (254_CR4) 2010; 465 E Mills (254_CR24) 2014; 24 S Anoopkumar-Dukie (254_CR41) 2005; 78 JD Buenrostro (254_CR30) 2013; 10 JK Salabei (254_CR48) 2014; 9 S Wang (254_CR34) 2018; 9 JJ Weening (254_CR39) 2004; 65 S Heinz (254_CR47) 2010; 38 F Rousset (254_CR21) 1992; 89 MD Buck (254_CR25) 2015; 212 Z Oaks (254_CR20) 2016; 18 A Chang (254_CR36) 2011; 186 M Gilliet (254_CR9) 2008; 8 MP Murphy (254_CR18) 2009; 417 M Gilliet (254_CR6) 2002; 63 P Blanco (254_CR35) 2005; 52 CM Tipton (254_CR2) 2015; 16 R Morita (254_CR28) 2011; 34 G Penna (254_CR11) 2001; 167 EV Acosta-Rodriguez (254_CR13) 2007; 8 E Arce (254_CR31) 2001; 167 T Ito (254_CR8) 2007; 204 254_CR29 G Jego (254_CR7) 2003; 19 J Peti-Peterdi (254_CR38) 2010; 78 AM Bolger (254_CR44) 2014; 30 TK Means (254_CR5) 2005; 115 A Guaras (254_CR17) 2016; 15 MC Hochberg (254_CR40) 1997; 40 T Dorner (254_CR32) 2004; 13 SK Jackson (254_CR14) 2002; 106 DA Rao (254_CR37) 2017; 542 M Locci (254_CR27) 2013; 39 LA Sena (254_CR15) 2013; 38 LH Glimcher (254_CR12) 2000; 14 H Ueno (254_CR23) 2015; 16 ME Keir (254_CR26) 2008; 26 S Nag (254_CR16) 2001; 81 GM Tannahill (254_CR19) 2013; 496 N Schmitt (254_CR42) 2014; 15 G Yu (254_CR46) 2015; 31 S Caielli (254_CR3) 2016; 213 H Li (254_CR45) 2009; 25 KW Moore (254_CR22) 2001; 19 AV Rubtsov (254_CR33) 2011; 118 GC Tsokos (254_CR1) 2011; 365 P Garrone (254_CR43) 1995; 182 G Grouard (254_CR10) 1997; 185 |
| References_xml | – volume: 63 start-page: 1149 year: 2002 end-page: 1155 ident: CR6 article-title: Human plasmacytoid-derived dendritic cells and the induction of T-regulatory cells publication-title: Hum. Immunol. doi: 10.1016/S0198-8859(02)00753-X contributor: fullname: Liu – volume: 212 start-page: 1345 year: 2015 end-page: 1360 ident: CR25 article-title: T cell metabolism drives immunity publication-title: J. Exp. Med. doi: 10.1084/jem.20151159 contributor: fullname: Pearce – volume: 40 start-page: 1725 year: 1997 ident: CR40 article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus publication-title: Arthritis Rheum. doi: 10.1002/art.1780400928 contributor: fullname: Hochberg – volume: 182 start-page: 1265 year: 1995 end-page: 1273 ident: CR43 article-title: Fas ligation induces apoptosis of CD40-activated human B lymphocytes publication-title: J. Exp. Med. doi: 10.1084/jem.182.5.1265 contributor: fullname: Garrone – volume: 19 start-page: 683 year: 2001 end-page: 765 ident: CR22 article-title: Interleukin-10 and the interleukin-10 receptor publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.19.1.683 contributor: fullname: O’Garra – volume: 204 start-page: 105 year: 2007 end-page: 115 ident: CR8 article-title: Plasmacytoid dendritic cells prime IL-10-producing T regulatory cells by inducible costimulator ligand publication-title: J. Exp. Med. doi: 10.1084/jem.20061660 contributor: fullname: Ito – volume: 167 start-page: 2361 year: 2001 end-page: 2369 ident: CR31 article-title: Increased frequency of pre-germinal center B cells and plasma cell precursors in the blood of children with systemic lupus erythematosus publication-title: J. Immunol. doi: 10.4049/jimmunol.167.4.2361 contributor: fullname: Arce – volume: 10 start-page: 1213 year: 2013 end-page: 1218 ident: CR30 article-title: Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position publication-title: Nat. Methods doi: 10.1038/nmeth.2688 contributor: fullname: Greenleaf – volume: 81 start-page: 41 year: 2001 end-page: 49 ident: CR16 article-title: Expression of nitric oxide synthases and nitrotyrosine during blood-brain barrier breakdown and repair after cold injury publication-title: Lab. Investig. doi: 10.1038/labinvest.3780210 contributor: fullname: Stewart – volume: 14 start-page: 1693 year: 2000 end-page: 1711 ident: CR12 article-title: Lineage commitment in the immune system: the T helper lymphocyte grows up publication-title: Genes Dev. contributor: fullname: Murphy – volume: 34 start-page: 108 year: 2011 end-page: 121 ident: CR28 article-title: Human blood CXCR5 CD4 T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion publication-title: Immunity doi: 10.1016/j.immuni.2010.12.012 contributor: fullname: Morita – volume: 31 start-page: 2382 year: 2015 end-page: 2383 ident: CR46 article-title: ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv145 contributor: fullname: He – ident: CR29 – volume: 78 start-page: 945 year: 2005 end-page: 947 ident: CR41 article-title: Resazurin assay of radiation response in cultured cells publication-title: Br. J. Radiol. doi: 10.1259/bjr/54004230 contributor: fullname: Anoopkumar-Dukie – volume: 465 start-page: 937 year: 2010 end-page: 941 ident: CR4 article-title: TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus publication-title: Nature doi: 10.1038/nature09102 contributor: fullname: Guiducci – volume: 18 start-page: 73 year: 2016 ident: CR20 article-title: Activation of the mechanistic target of rapamycin in SLE: explosion of evidence in the last five years publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-016-0622-8 contributor: fullname: Perl – volume: 38 start-page: 225 year: 2013 end-page: 236 ident: CR15 article-title: Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling publication-title: Immunity doi: 10.1016/j.immuni.2012.10.020 contributor: fullname: Sena – volume: 118 start-page: 1305 year: 2011 end-page: 1315 ident: CR33 article-title: Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c B-cell population is important for the development of autoimmunity publication-title: Blood doi: 10.1182/blood-2011-01-331462 contributor: fullname: Rubtsov – volume: 52 start-page: 201 year: 2005 end-page: 211 ident: CR35 article-title: Increase in activated CD8 T lymphocytes expressing perforin and granzyme B correlates with disease activity in patients with systemic lupus erythematosus publication-title: Arthritis Rheum. doi: 10.1002/art.20745 contributor: fullname: Blanco – volume: 186 start-page: 1849 year: 2011 end-page: 1860 ident: CR36 article-title: In situ B cell-mediated immune responses and tubulointerstitial inflammation in human lupus nephritis publication-title: J. Immunol. doi: 10.4049/jimmunol.1001983 contributor: fullname: Chang – volume: 8 start-page: 639 year: 2007 end-page: 646 ident: CR13 article-title: Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells publication-title: Nat. Immunol. doi: 10.1038/ni1467 contributor: fullname: Acosta-Rodriguez – volume: 15 start-page: 856 year: 2014 end-page: 865 ident: CR42 article-title: The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells publication-title: Nat. Immunol. doi: 10.1038/ni.2947 contributor: fullname: Schmitt – volume: 78 start-page: 1214 year: 2010 end-page: 1217 ident: CR38 article-title: High glucose and renin release: the role of succinate and GPR91 publication-title: Kidney Int. doi: 10.1038/ki.2010.333 contributor: fullname: Peti-Peterdi – volume: 65 start-page: 521 year: 2004 end-page: 530 ident: CR39 article-title: The classification of glomerulonephritis in systemic lupus erythematosus revisited publication-title: Kidney Int. doi: 10.1111/j.1523-1755.2004.00443.x contributor: fullname: Weening – volume: 16 start-page: 755 year: 2015 end-page: 765 ident: CR2 article-title: Diversity, cellular origin and autoreactivity of antibody-secreting cell population expansions in acute systemic lupus erythematosus publication-title: Nat. Immunol. doi: 10.1038/ni.3175 contributor: fullname: Tipton – volume: 24 start-page: 313 year: 2014 end-page: 320 ident: CR24 article-title: Succinate: a metabolic signal in inflammation publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2013.11.008 contributor: fullname: O’Neill – volume: 365 start-page: 2110 year: 2011 end-page: 2121 ident: CR1 article-title: Systemic lupus erythematosus publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1100359 contributor: fullname: Tsokos – volume: 15 start-page: 197 year: 2016 end-page: 209 ident: CR17 article-title: The CoQH /CoQ ratio serves as a sensor of respiratory chain efficiency publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.03.009 contributor: fullname: Guaras – volume: 496 start-page: 238 year: 2013 end-page: 242 ident: CR19 article-title: Succinate is an inflammatory signal that induces IL-1β through HIF-1ɑ publication-title: Nature doi: 10.1038/nature11986 contributor: fullname: Tannahill – volume: 25 start-page: 1754 year: 2009 end-page: 1760 ident: CR45 article-title: Fast and accurate short read alignment with Burrows-Wheeler transform publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp324 contributor: fullname: Durbin – volume: 30 start-page: 2114 year: 2014 end-page: 2120 ident: CR44 article-title: Trimmomatic: a flexible trimmer for Illumina sequence data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: Usadel – volume: 167 start-page: 1862 year: 2001 end-page: 1866 ident: CR11 article-title: Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells publication-title: J. Immunol. doi: 10.4049/jimmunol.167.4.1862 contributor: fullname: Adorini – volume: 16 start-page: 142 year: 2015 end-page: 152 ident: CR23 article-title: Pathophysiology of T follicular helper cells in humans and mice publication-title: Nat. Immunol. doi: 10.1038/ni.3054 contributor: fullname: Vinuesa – volume: 26 start-page: 677 year: 2008 end-page: 704 ident: CR26 article-title: PD-1 and its ligands in tolerance and immunity publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090331 contributor: fullname: Sharpe – volume: 106 start-page: 486 year: 2002 end-page: 495 ident: CR14 article-title: The ability of antigen, but not interleukin-2, to promote -butyrate-induced T helper 1 cell anergy is associated with increased expression and altered association patterns of cyclin-dependent kinase inhibitors publication-title: Immunology doi: 10.1046/j.1365-2567.2002.01457.x contributor: fullname: Gilbert – volume: 115 start-page: 407 year: 2005 end-page: 417 ident: CR5 article-title: Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9 publication-title: J. Clin. Investig. doi: 10.1172/JCI23025 contributor: fullname: Means – volume: 8 start-page: 594 year: 2008 end-page: 606 ident: CR9 article-title: Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2358 contributor: fullname: Liu – volume: 417 start-page: 1 year: 2009 end-page: 13 ident: CR18 article-title: How mitochondria produce reactive oxygen species publication-title: Biochem. J. doi: 10.1042/BJ20081386 contributor: fullname: Murphy – volume: 89 start-page: 1890 year: 1992 end-page: 1893 ident: CR21 article-title: Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.89.5.1890 contributor: fullname: Rousset – volume: 9 year: 2018 ident: CR34 article-title: IL-21 drives expansion and plasma cell differentiation of autoreactive CD11c T-bet B cells in SLE publication-title: Nat. Commun. doi: 10.1038/s41467-018-03750-7 contributor: fullname: Wang – volume: 9 start-page: 421 year: 2014 end-page: 438 ident: CR48 article-title: Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.018 contributor: fullname: Hill – volume: 19 start-page: 225 year: 2003 end-page: 234 ident: CR7 article-title: Plasmacytoid dendritic cells induce plasma cell differentiation through type I interferon and interleukin 6 publication-title: Immunity doi: 10.1016/S1074-7613(03)00208-5 contributor: fullname: Jego – volume: 542 start-page: 110 year: 2017 end-page: 114 ident: CR37 article-title: Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis publication-title: Nature doi: 10.1038/nature20810 contributor: fullname: Rao – volume: 38 start-page: 576 year: 2010 end-page: 589 ident: CR47 article-title: Simple combinations of lineage-determining transcription factors prime -regulatory elements required for macrophage and B cell identities publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 contributor: fullname: Heinz – volume: 213 start-page: 697 year: 2016 end-page: 713 ident: CR3 article-title: Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus publication-title: J. Exp. Med. doi: 10.1084/jem.20151876 contributor: fullname: Caielli – volume: 39 start-page: 758 year: 2013 end-page: 769 ident: CR27 article-title: Human circulating PD-1 CXCR3 CXCR5 memory T cells are highly functional and correlate with broadly neutralizing HIV antibody responses publication-title: Immunity doi: 10.1016/j.immuni.2013.08.031 contributor: fullname: Locci – volume: 185 start-page: 1101 year: 1997 end-page: 1111 ident: CR10 article-title: The enigmatic plasmacytoid T cells develop into dendritic cells with interleukin (IL)-3 and CD40-ligand publication-title: J. Exp. Med. doi: 10.1084/jem.185.6.1101 contributor: fullname: Grouard – volume: 13 start-page: 283 year: 2004 end-page: 289 ident: CR32 article-title: Correlation of circulating CD27 plasma cells and disease activity in systemic lupus erythematosus publication-title: Lupus doi: 10.1191/0961203304lu1014oa contributor: fullname: Lipsky – volume: 16 start-page: 142 year: 2015 ident: 254_CR23 publication-title: Nat. Immunol. doi: 10.1038/ni.3054 contributor: fullname: H Ueno – volume: 19 start-page: 683 year: 2001 ident: 254_CR22 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.19.1.683 contributor: fullname: KW Moore – volume: 25 start-page: 1754 year: 2009 ident: 254_CR45 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btp324 contributor: fullname: H Li – volume: 40 start-page: 1725 year: 1997 ident: 254_CR40 publication-title: Arthritis Rheum. doi: 10.1002/art.1780400928 contributor: fullname: MC Hochberg – volume: 63 start-page: 1149 year: 2002 ident: 254_CR6 publication-title: Hum. Immunol. doi: 10.1016/S0198-8859(02)00753-X contributor: fullname: M Gilliet – volume: 9 year: 2018 ident: 254_CR34 publication-title: Nat. Commun. doi: 10.1038/s41467-018-03750-7 contributor: fullname: S Wang – volume: 465 start-page: 937 year: 2010 ident: 254_CR4 publication-title: Nature doi: 10.1038/nature09102 contributor: fullname: C Guiducci – volume: 30 start-page: 2114 year: 2014 ident: 254_CR44 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btu170 contributor: fullname: AM Bolger – volume: 15 start-page: 856 year: 2014 ident: 254_CR42 publication-title: Nat. Immunol. doi: 10.1038/ni.2947 contributor: fullname: N Schmitt – volume: 14 start-page: 1693 year: 2000 ident: 254_CR12 publication-title: Genes Dev. doi: 10.1101/gad.14.14.1693 contributor: fullname: LH Glimcher – volume: 417 start-page: 1 year: 2009 ident: 254_CR18 publication-title: Biochem. J. doi: 10.1042/BJ20081386 contributor: fullname: MP Murphy – volume: 39 start-page: 758 year: 2013 ident: 254_CR27 publication-title: Immunity doi: 10.1016/j.immuni.2013.08.031 contributor: fullname: M Locci – volume: 213 start-page: 697 year: 2016 ident: 254_CR3 publication-title: J. Exp. Med. doi: 10.1084/jem.20151876 contributor: fullname: S Caielli – volume: 8 start-page: 594 year: 2008 ident: 254_CR9 publication-title: Nat. Rev. Immunol. doi: 10.1038/nri2358 contributor: fullname: M Gilliet – volume: 115 start-page: 407 year: 2005 ident: 254_CR5 publication-title: J. Clin. Investig. doi: 10.1172/JCI23025 contributor: fullname: TK Means – volume: 365 start-page: 2110 year: 2011 ident: 254_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra1100359 contributor: fullname: GC Tsokos – volume: 542 start-page: 110 year: 2017 ident: 254_CR37 publication-title: Nature doi: 10.1038/nature20810 contributor: fullname: DA Rao – volume: 34 start-page: 108 year: 2011 ident: 254_CR28 publication-title: Immunity doi: 10.1016/j.immuni.2010.12.012 contributor: fullname: R Morita – volume: 16 start-page: 755 year: 2015 ident: 254_CR2 publication-title: Nat. Immunol. doi: 10.1038/ni.3175 contributor: fullname: CM Tipton – volume: 185 start-page: 1101 year: 1997 ident: 254_CR10 publication-title: J. Exp. Med. doi: 10.1084/jem.185.6.1101 contributor: fullname: G Grouard – volume: 118 start-page: 1305 year: 2011 ident: 254_CR33 publication-title: Blood doi: 10.1182/blood-2011-01-331462 contributor: fullname: AV Rubtsov – volume: 186 start-page: 1849 year: 2011 ident: 254_CR36 publication-title: J. Immunol. doi: 10.4049/jimmunol.1001983 contributor: fullname: A Chang – volume: 496 start-page: 238 year: 2013 ident: 254_CR19 publication-title: Nature doi: 10.1038/nature11986 contributor: fullname: GM Tannahill – volume: 182 start-page: 1265 year: 1995 ident: 254_CR43 publication-title: J. Exp. Med. doi: 10.1084/jem.182.5.1265 contributor: fullname: P Garrone – volume: 15 start-page: 197 year: 2016 ident: 254_CR17 publication-title: Cell Rep. doi: 10.1016/j.celrep.2016.03.009 contributor: fullname: A Guaras – volume: 10 start-page: 1213 year: 2013 ident: 254_CR30 publication-title: Nat. Methods doi: 10.1038/nmeth.2688 contributor: fullname: JD Buenrostro – volume: 106 start-page: 486 year: 2002 ident: 254_CR14 publication-title: Immunology doi: 10.1046/j.1365-2567.2002.01457.x contributor: fullname: SK Jackson – volume: 167 start-page: 2361 year: 2001 ident: 254_CR31 publication-title: J. Immunol. doi: 10.4049/jimmunol.167.4.2361 contributor: fullname: E Arce – volume: 89 start-page: 1890 year: 1992 ident: 254_CR21 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.89.5.1890 contributor: fullname: F Rousset – volume: 65 start-page: 521 year: 2004 ident: 254_CR39 publication-title: Kidney Int. doi: 10.1111/j.1523-1755.2004.00443.x contributor: fullname: JJ Weening – ident: 254_CR29 doi: 10.1126/sciimmunol.aan8664 – volume: 167 start-page: 1862 year: 2001 ident: 254_CR11 publication-title: J. Immunol. doi: 10.4049/jimmunol.167.4.1862 contributor: fullname: G Penna – volume: 19 start-page: 225 year: 2003 ident: 254_CR7 publication-title: Immunity doi: 10.1016/S1074-7613(03)00208-5 contributor: fullname: G Jego – volume: 212 start-page: 1345 year: 2015 ident: 254_CR25 publication-title: J. Exp. Med. doi: 10.1084/jem.20151159 contributor: fullname: MD Buck – volume: 24 start-page: 313 year: 2014 ident: 254_CR24 publication-title: Trends Cell Biol. doi: 10.1016/j.tcb.2013.11.008 contributor: fullname: E Mills – volume: 13 start-page: 283 year: 2004 ident: 254_CR32 publication-title: Lupus doi: 10.1191/0961203304lu1014oa contributor: fullname: T Dorner – volume: 26 start-page: 677 year: 2008 ident: 254_CR26 publication-title: Annu. Rev. Immunol. doi: 10.1146/annurev.immunol.26.021607.090331 contributor: fullname: ME Keir – volume: 78 start-page: 1214 year: 2010 ident: 254_CR38 publication-title: Kidney Int. doi: 10.1038/ki.2010.333 contributor: fullname: J Peti-Peterdi – volume: 31 start-page: 2382 year: 2015 ident: 254_CR46 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btv145 contributor: fullname: G Yu – volume: 38 start-page: 225 year: 2013 ident: 254_CR15 publication-title: Immunity doi: 10.1016/j.immuni.2012.10.020 contributor: fullname: LA Sena – volume: 204 start-page: 105 year: 2007 ident: 254_CR8 publication-title: J. Exp. Med. doi: 10.1084/jem.20061660 contributor: fullname: T Ito – volume: 18 start-page: 73 year: 2016 ident: 254_CR20 publication-title: Curr. Rheumatol. Rep. doi: 10.1007/s11926-016-0622-8 contributor: fullname: Z Oaks – volume: 9 start-page: 421 year: 2014 ident: 254_CR48 publication-title: Nat. Protoc. doi: 10.1038/nprot.2014.018 contributor: fullname: JK Salabei – volume: 38 start-page: 576 year: 2010 ident: 254_CR47 publication-title: Mol. Cell doi: 10.1016/j.molcel.2010.05.004 contributor: fullname: S Heinz – volume: 78 start-page: 945 year: 2005 ident: 254_CR41 publication-title: Br. J. Radiol. doi: 10.1259/bjr/54004230 contributor: fullname: S Anoopkumar-Dukie – volume: 52 start-page: 201 year: 2005 ident: 254_CR35 publication-title: Arthritis Rheum. doi: 10.1002/art.20745 contributor: fullname: P Blanco – volume: 8 start-page: 639 year: 2007 ident: 254_CR13 publication-title: Nat. Immunol. doi: 10.1038/ni1467 contributor: fullname: EV Acosta-Rodriguez – volume: 81 start-page: 41 year: 2001 ident: 254_CR16 publication-title: Lab. Investig. doi: 10.1038/labinvest.3780210 contributor: fullname: S Nag |
| SSID | ssj0003059 |
| Score | 2.673937 |
| Snippet | Understanding the mechanisms underlying autoantibody development will accelerate therapeutic target identification in autoimmune diseases such as systemic... |
| SourceID | proquest crossref pubmed springer |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 75 |
| SubjectTerms | 631/250/249/1313/1613/1614 631/250/38 Apoptosis Autoantibodies Autoimmune diseases B-Lymphocytes - immunology Biomedical and Life Sciences Biomedicine Blood Cancer Research CD4 antigen CD4-Positive T-Lymphocytes - immunology Cell Proliferation Chronic conditions CXCR3 protein CXCR5 protein Cytokines Dendritic cells Dendritic Cells - metabolism Deoxyribonucleic acid DNA DNA, Mitochondrial - genetics Electron transport Humans Immunologic Memory Infectious Diseases Interleukin 10 Interleukin 21 Interleukin-10 - metabolism Letter Lupus Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Lupus nephritis Lupus Nephritis - immunology Lymphocytes Lymphocytes B Lymphocytes T Metabolic Diseases Mitochondrial DNA Molecular Medicine Nephritis Neurosciences Oxidation-Reduction Pathogenesis PD-1 protein Priming Reactive oxygen species Succinic Acid - metabolism Systemic lupus erythematosus Target recognition Therapeutic applications Toll-like receptors |
| Title | A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate |
| URI | https://link.springer.com/article/10.1038/s41591-018-0254-9 https://www.ncbi.nlm.nih.gov/pubmed/30478422 https://www.proquest.com/docview/2164537870 https://www.proquest.com/docview/2138648929/abstract/ |
| Volume | 25 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LS8NAEB7UongR38ZHWcGTstg8Nt2cpFWLCBYRhd5Csg-sljSaBvTfO5tsKiJ6yiHZR2ZmZ76dmd0BOGEd4aaJSKiWStEg0j5Fs6ApKkIeqrCTqqpm5N0wvHkKbkdsZB1uhU2rbHRipajlVBgf-bmHuJ75Rrwu8jdqqkaZ6KotobEILc8NTJi21b8e3j_MdTFKc1RnHXLKcSvQxDV9fl6g6TJZPy6n5kQ4jX5apl9w81eotLJAg3VYs9CR9Gpeb8CCyjZhuS4m-bkJK3c2TL4FLz1yeRWckUdi_PIknxfpIuojN15jScYZmZR5WZAqc53YA3kF6ddNntUkJ7aGDzFXSrxPVPk6zlCfEuyAFKXAoRCnbsPT4Prx8obaogpU4A_PqMT9X5QiShBCub70tEyiNHGlqz0VsJRJXKBM6uqhXaECLjWXXDLOE2nAyA4sZdNM7QHx_ERJJlMhsCnXjOuwG7qqIzTzmEyYA6cNQeO8vjsjrmLePo9r6sdI_dhQP44cOGxIHttlVMTfTHfgeP4aF4AhRZKpaWm-8XkYcIR5DuzWrJqPZmKKPPA8B84a3n13_udU9v-fygGsImqKaj_MISzN3kt1hMhklrZhsTvqtqHVG_T7w7YVxi9ELuGG |
| link.rule.ids | 315,786,790,12083,21416,27955,27956,31752,31753,33777,33778,43343,43838,74100,74657 |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9wwEB61VC29oEILpNBipJ6KLDaxnXVO1ZYWLY_ltEh7sxI_xGOVDWQjtf--48RZVKH2lEPiR2bGM59nxh6AL2Kg4yLXOXXGWsozxyiaBUdREcrUpoPCtjUjJ1fp-Jqfz8QsONzqkFbZ68RWUZuF9j7y4wRxvWBevL5VD9RXjfLR1VBC4yW84oxxL-fD2WrD5WU563IOJZW4Eeijmkwe12i4fM5PLKk_D06zv-3SM7D5LFDa2p_Td7ARgCMZdZzehBe23ILXXSnJ31vwZhKC5O_hbkROfvAjMiXeK0-qVYkuYn9V3mdsyG1J5k3V1KTNWyfhOF5NvndNbuy8IqGCD_EXSjzObXN_W6I2JdgBqRuNQyFK_QDXpz-nJ2MaSipQjT-8pAZ3f1mBGEFrGzOTOJNnRR6b2CWWi0IYXJ7CuPbhYm25NE4aaYSUufFQZBvWykVpd4EkLLdGmEJrbCqdkC4dprEdaCcSYXIRwdeeoKrqbs5QbcSbSdVRXyH1lae-yiLY70muwiKq1RPLIzhcvUbx96TIS7to_DdMplwiyItgp2PVajQfUZQ8SSI46nn31Pk_p_Lx_1M5gPXxdHKpLs-uLvbgLeKnrPPI7MPa8rGxnxCjLIvPrSD-AcxH4Ko |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1LT9tAEB6VVCAuiPJoDaHdSj2BVokfa9YnxKMR0CbiAFJuK3sfIm3kGBxL7b9n1l4nQhGcfLD34ZnZmW9nZncAfrC-9LNUptQorWmUmJCiWTAUFSGPddzPdF0zcjiKrx-i2zEbu_yn0qVVtjqxVtRqJq2PvBcgrmehFa-ecWkRd1eDs-KJ2gpSNtLqymmswUe0kn1bxuF0vNh8WblOmvxDTjluCtoIZ8h7JRoxm__jc2rPhtPktY1aAZ4rQdPaFg22YcuBSHLecP0TfND5Dqw3ZSX_78DG0AXMd-HPObm8ik7IPbEeelIsynUR_a-w_mNFJjmZVkVVkjqHnbijeSW5aJo86mlBXDUfYi-XeJ7q6u8kR81KsANSVhKHQsS6Bw-Dn_eX19SVV6ASf3hOFe4EkwzxgpTaD1VgVJpkqa98E-iIZUzhUmXK1A_jSx1xZbjiinGeKgtL9qGTz3L9BUgQploxlUmJTblh3MSnsa_70rCAqZR5cNwSVBTNLRqijn6HXDTUF0h9YakvEg-6LcmFW1ClWLLfg--L17gULCnSXM8q-03I44gj4PPgc8OqxWg2usijIPDgpOXdsvM3p3Lw_lS-wQbKoPh9M_p1CJsIpZLGOdOFzvy50kcIV-bZ11oOXwBjBuTW |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+CD4+%2B+T+cell+population+expanded+in+lupus+blood+provides+B+cell+help+through+interleukin-10+and+succinate&rft.jtitle=Nature+medicine&rft.au=Caielli%2C+Simone&rft.au=Veiga%2C+Diogo+Troggian&rft.au=Balasubramanian%2C+Preetha&rft.au=Athale%2C+Shruti&rft.date=2019-01-01&rft.eissn=1546-170X&rft.volume=25&rft.issue=1&rft.spage=75&rft_id=info:doi/10.1038%2Fs41591-018-0254-9&rft_id=info%3Apmid%2F30478422&rft.externalDocID=30478422 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1078-8956&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1078-8956&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1078-8956&client=summon |