Administration of Wasabia koreana Ameliorates Irritable Bowel Syndrome-Like Symptoms in a Zymosan-Induced Mouse Model

• Published in: Journal of medicinal food Vol. 20; no. 5; p. 474
• Main Authors: Park, Bo-Kyung, Chun, Eunho, Choi, Jeong June, Shin, Younmin, Kho, Young Tak, Oh, Seung Hyun, Kim, Sun Yeou, Lee, Taek Hwan, Kim, Tae-Wan, Shin, Eunju, Do, Seon-Gil, Jin, Mirim
• Format: Journal Article
• Language: English
• Published: United States 01.05.2017
• Subjects: Animals; Colon - drug effects; Colon - immunology; Disease Models, Animal; Humans; Irritable Bowel Syndrome - chemically induced; Irritable Bowel Syndrome - drug therapy; Irritable Bowel Syndrome - immunology; Male; Mice; Mice, Inbred C57BL; Plant Extracts - administration & dosage; Plant Extracts - analysis; Tumor Necrosis Factor-alpha - immunology; Wasabia - chemistry; Zymosan - adverse effects; anxiety; colonic inflammation; pain; wasabi; zymosan; animal model; diarrhea-predominant irritable bowel syndrome
• ISSN: 1557-7600
• DOI: 10.1089/jmf.2016.3844

Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with complex pathophysiology involving the brain-gut axis. To assess the effects of Wasabia koreana (WK) on IBS, we employed a mouse model of colonic zymosan injection presenting with diarrhea-predominant IBS-like symptoms. Oral...