Effects of Dextroamphetamine on Cognitive Performance and Cortical Activation

• Published in: NeuroImage (Orlando, Fla.) Vol. 12; no. 3; pp. 268 - 275
• Main Authors: Mattay, Venkata S., Callicott, Joseph H., Bertolino, Alessandro, Heaton, Ian, Frank, Joseph A., Coppola, Richard, Berman, Karen F., Goldberg, Terry E., Weinberger, Daniel R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2000; Elsevier Limited
• Subjects: Adult; BOLD fMRI; catecholamines; Central Nervous System Stimulants - pharmacology; Cerebral Cortex - drug effects; cognition; Cognition - drug effects; Cognitive ability; cortical activation; Cross-Over Studies; dextroamphetamine; Dextroamphetamine - pharmacology; dopamine; Double-Blind Method; Female; Functional magnetic resonance imaging; Genetic diversity; Humans; Image Processing, Computer-Assisted; Individuality; Magnetic Resonance Imaging; Male; Memory; Memory, Short-Term - drug effects; Mental task performance; Neurotransmitters; Prefrontal cortex; Psychomotor Performance - drug effects; Short term memory; working memory; catecholamines; cognition; working memory; dopamine; dextroamphetamine; BOLD fMRI; cortical activation

Monoaminergic neurotransmitters are known to have modulatory effects on cognition and on neurophysiological function in the cortex. The current study was performed with BOLD fMRI to examine physiological correlates of the effects of dextroamphetamine on working-memory performance in healthy controls...