GABAergic Neurons Immunoreactive for Calcium Binding Proteins are Reduced in the Prefrontal Cortex in Major Depression

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 32; no. 2; pp. 471 - 482
• Main Authors: Rajkowska, Grazyna, O'Dwyer, Gillian, Teleki, Zsofia, Stockmeier, Craig A, Miguel-Hidalgo, Jose Javier
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.02.2007
• Subjects: Adult; Aged; Biomarkers - metabolism; Calbindins; Calcium-Binding Proteins - metabolism; Cell Count; Cell Size; Depressive Disorder, Major - metabolism; Depressive Disorder, Major - pathology; Depressive Disorder, Major - physiopathology; Down-Regulation - physiology; Female; gamma-Aminobutyric Acid - metabolism; Humans; Immunohistochemistry; Interneurons - metabolism; Male; Mental depression; Middle Aged; Neurons; Parvalbumins - metabolism; Pathology; Prefrontal Cortex - metabolism; Prefrontal Cortex - pathology; Prefrontal Cortex - physiopathology; Proteins; Psychiatry; S100 Calcium Binding Protein G - metabolism; Schizophrenia; United States > US

Post-mortem morphometric studies report reductions in the average density and size of cortical neurons in the dorsolateral prefrontal cortex (dlPFC) and orbitofrontal cortex (ORB) in major depressive disorder (MDD). The contribution of specific neuronal phenotypes to this general pathology in depres...