Long non‑coding RNA 01614 hyperactivates WNT/β‑catenin signaling to promote pancreatic cancer progression by suppressing GSK‑3β

• Published in: International journal of oncology Vol. 61; no. 4
• Main Authors: Chen, Long-Jiang, Wu, Lun, Wang, Wei, Zhai, Lu-Lu, Xiang, Feng, Li, Wei-Bo, Tang, Zhi-Gang
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.10.2022; D.A. Spandidos
• Subjects: beta Catenin - genetics; beta Catenin - metabolism; Cell growth; Cell Line, Tumor; Cell Movement - genetics; Cell Proliferation - genetics; Gene expression; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta - genetics; Glycogen Synthase Kinase 3 beta - metabolism; Humans; Hybridization; Laboratories; Pancreatic cancer; Pancreatic Neoplasms; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Proteins; Reagents; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Wnt Signaling Pathway - genetics; pancreatic cancer; linc01614; WNT/β‑catenin signaling pathway; GSK‑3β

Pancreatic cancer (PC) is a lethal type of cancer for which effective therapies are limited. Long non‑coding RNAs (lncRNAs) represent a critical type of regulator category, mediating the tumorigenesis and development of various tumor types, including PC. However, the expression patterns and function...