Influence of the Ward Colon Tumor on the Innate and Endotoxin-Induced Inflammatory Response of the Rat

• Published in: Cancer investigation Vol. 19; no. 7; pp. 698 - 705
• Main Author: Grossie, V. Bruce
• Format: Journal Article
• Language: English
• Published: New York, NY Informa UK Ltd 2001; Taylor & Francis; Informa Healthcare
• Subjects: Animal tumors. Experimental tumors; Animals; Biological and medical sciences; Colonic Neoplasms - physiopathology; Endotoxin; Endotoxins - pharmacology; Enzyme Induction; Experimental digestive system and abdominal tumors; Foreign-Body Reaction - physiopathology; Granuloma - pathology; Immunosuppression; Infection; Inflammation; Inflammatory response; liver; Liver - physiology; Lymphocyte Subsets; Male; Medical sciences; Neoplasms, Experimental; Nitric Oxide; Nitric oxide synthase; Rats; Rats, Inbred F344; Transplantation, Heterologous; Tumors; Ward colon tumor; Granuloma; Immune response; Rat; Immunomodulation; Escherichia coli; Rodentia; Natural immunity; Cachexia; Inflammation; Malignant tumor; Endotoxin; Colonic disease; Infection; Vertebrata; Immunosuppression; Mammalia; Animal; Lipopolysaccharide; Digestive diseases; Bacteria; Intestinal disease; Colon; Enterobacteriaceae

Cachexia, a depressed immune function, and an increased infection rate are recurring problems for cancer patients; the response of the host to an infection may also be increased. We have reported that the transplantable Ward colon tumor (WCT) enhanced the lethality of endotoxin (lipopolysaccharide [...