Inflammation and asthma

• Published in: Journal of allergy and clinical immunology Vol. 73; no. 5; pp. 651 - 653
• Main Author: Nadel, J.A.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: United States Mosby, Inc 01.05.1984
• Subjects: Animals; Arachidonic Acids - biosynthesis; Asthma - etiology; Cell Communication; Chemotactic Factors - biosynthesis; Dinoprostone; Dogs; Epithelial Cells; Epithelium - metabolism; Humans; Hydroxyeicosatetraenoic Acids; Inflammation - complications; Interleukin-8; Leukotriene B4 - biosynthesis; Neutrophils - cytology; Ozone - adverse effects; Prostaglandins E - biosynthesis; Sputum - cytology

Extreme sensitivity of airways to multiple stimuli characterizes asthma. Airway hyperresponsiveness can be produced experimentally in otherwise healthy subjects or animals by inflammatory damage (e.g., induced by respiratory viruses or by inhaled oxidants). Evidence is presented that cell-to-cell in...