Natural Autoimmunity to Selenoprotein P Impairs Selenium Transport in Hashimoto’s Thyroiditis

• Published in: International journal of molecular sciences Vol. 22; no. 23; p. 13088
• Main Authors: Sun, Qian, Mehl, Sebastian, Renko, Kostja, Seemann, Petra, Görlich, Christian L., Hackler, Julian, Minich, Waldemar B., Kahaly, George J., Schomburg, Lutz
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.12.2021; MDPI
• Subjects: Adult; Animals; Autoantibodies - blood; Autoimmunity; Biomarkers; Biosynthesis; Female; Gene expression; Glutathione; Glutathione Peroxidase - blood; Glutathione Peroxidase - metabolism; Hashimoto Disease - blood; Hashimoto Disease - immunology; Hashimoto Disease - metabolism; Human subjects; Humans; Hypotheses; Inflammation; Male; Middle Aged; Proteins; Selenium - blood; Selenoprotein P - immunology; Thyroid diseases; trace element; Hashimoto’s thyroiditis; autoantibody; antioxidative defense; glutathione peroxidase

The essential trace element selenium (Se) is needed for the biosynthesis of selenocysteine-containing selenoproteins, including the secreted enzyme glutathione peroxidase 3 (GPX3) and the Se-transporter selenoprotein P (SELENOP). Both are found in blood and thyroid colloid, where they serve protecti...