Phase I Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults from Puerto Rico

• Published in: The American journal of tropical medicine and hygiene Vol. 98; no. 5; pp. 1435 - 1443
• Main Authors: Diaz, Clemente, Lin, Leyi, Martinez, Luis J., Eckels, Kenneth H., Campos, Maribel, Jarman, Richard G., De La Barrera, Rafael, Lepine, Edith, Toussaint, Jean-François, Febo, Irma, Innis, Bruce L., Thomas, Stephen J., Schmidt, Alexander C.
• Format: Journal Article
• Language: English
• Published: United States Institute of Tropical Medicine 01.01.2018; The American Society of Tropical Medicine and Hygiene
• Subjects: Vaccines; United States > US; Puerto Rico

The safety and immunogenicity of four adjuvanted formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV) were evaluated in a predominantly dengue-primed population in Puerto Rico. In this placebo-controlled, randomized, observer-blind, phase I trial, 100 healthy adu...