High-throughput drug screening to investigate blood-brain barrier permeability in vitro with a focus on breast cancer chemotherapeutic agents

• Published in: Frontiers in Drug Delivery Vol. 4
• Main Authors: Curtaz, Carolin J., Wucherpfennig, Sophia, Al-Masnaea, Emad, Herbert, Saskia-Laureen, Wöckel, Achim, Meybohm, Patrick, Burek, Malgorzata
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 27.06.2024
• Subjects: 4-amino-1,8-naphthalimide; blood-brain barrier; Drug Delivery; GW2974; high-throughput drug screening; in vitro models; metastatic breast cancer

Therapy of cerebral diseases such as brain metastatic breast cancer is still challenging. Due to the blood-brain barrier (BBB), a tight barrier that protects the brain and prevents the passage of many drugs, therapeutically sufficient drug concentrations in the brain are often not achieved. Therefor...