Evaluation of Drug–Drug Interaction Potential between Baloxavir Marboxil and Oseltamivir in Healthy Subjects

• Published in: Clinical drug investigation Vol. 38; no. 11; pp. 1053 - 1060
• Main Authors: Kawaguchi, Nao, Koshimichi, Hiroki, Ishibashi, Toru, Wajima, Toshihiro
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2018; Springer Nature B.V
• Subjects: Administration, Oral; Adult; Antiviral Agents - administration & dosage; Antiviral Agents - blood; Antiviral drugs; Cross-Over Studies; Cytochrome; Drug dosages; Drug Evaluation, Preclinical - methods; Drug Interactions - physiology; Drug Therapy, Combination; Enzyme Inhibitors - administration & dosage; Enzyme Inhibitors - blood; Glycoproteins; Healthy Volunteers; Humans; Infectious diseases; Influenza; Internal Medicine; Male; Medicine; Medicine & Public Health; Middle Aged; Original Research Article; Oseltamivir - administration & dosage; Oseltamivir - blood; Peptides; Pharmacology/Toxicology; Pharmacotherapy; Prodrugs - administration & dosage; Prodrugs - metabolism; Studies; Viruses; Young Adult; United States > US; Japan

Background and Objective Baloxavir marboxil is a prodrug that is metabolized to baloxavir acid, which suppresses viral replication by inhibiting cap-dependent endonuclease with a single oral administration. As the mode of action of baloxavir marboxil is different from that of neuraminidase inhibitor...