Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation - Pino, Gonzalo L. Gonzalez-Del; Li, Kunhua; Park, Eunyoung; Schmoker, Anna M.; Ha, Byung Hak; Eck, Michael J. (Proceedings of the National Academy of Sciences - PNAS, 2021)
Keywords: Allosteric Regulation; Biological Sciences; Enzyme Activation; Enzyme Stability; Humans; MAP Kinase Kinase Kinases - antagonists & inhibitors; MAP Kinase Kinase Kinases - chemistry; MAP Kinase Kinase Kinases - metabolism; Phosphorylation; Protein Conformation; Protein Kinase Inhibitors - pharmacology; Proto-Oncogene Proteins B-raf - metabolism; Signal Transduction; X-ray crystallography; MEK; BRAF; MEK inhibitor; allosteric kinase inhibitor