PPARα activation alleviates damage to the cytoskeleton during acute myocardial ischemia/reperfusion in rats

• Published in: Molecular medicine reports Vol. 17; no. 5; pp. 7218 - 7226
• Main Authors: Yuan, Jie, Mo, Hongdan, Luo, Jing, Zhao, Suhong, Liang, Shuang, Jiang, Yu, Zhang, Maomao
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications UK Ltd 01.05.2018; D.A. Spandidos
• Subjects: Acute Disease; Animals; Calpain; Cardiomyocytes; Coronary artery; Cytoskeleton; Cytoskeleton - metabolism; Cytoskeleton - pathology; Desmin; Desmin - metabolism; EKG; Endoplasmic reticulum; Endoplasmic Reticulum Stress; Fenofibrate; Heart; Heart diseases; Homeostasis; Ischemia; Kinases; Laboratory animals; Lipids; Liver; Male; Metabolism; Microscopy; Morphology; Myocardial ischemia; Myocardial Reperfusion Injury - metabolism; Myocardial Reperfusion Injury - pathology; Myocardium; Myocardium - metabolism; Myocardium - pathology; Myocytes, Cardiac - metabolism; Myocytes, Cardiac - pathology; Physiology; PPAR alpha - metabolism; Protein expression; Proteins; Proteolysis; Pulmonary arteries; Rats; Rats, Wistar; Reperfusion; Rodents; Signal transduction; Studies; Therapeutic applications; Transmission electron microscopy; Ultrastructure

The cytoskeleton serves an important role in maintaining cellular morphology and function, and it is a substrate of calpain during myocardial ischemia/reperfusion (I/R) injury (MIRI). Calpain may be activated by endoplasmic reticulum (ER) stress during MIRI. The activation of peroxisome proliferator...