Effect of Latanoprost on Intraocular Pressure in Mice Lacking the Prostaglandin FP Receptor

• Published in: Investigative ophthalmology & visual science Vol. 45; no. 10; pp. 3555 - 3559
• Main Authors: Crowston, Jonathan G, Lindsey, James D, Aihara, Makoto, Weinreb, Robert N
• Format: Journal Article
• Language: English
• Published: Rockville, MD ARVO 01.10.2004; Association for Research in Vision and Ophtalmology
• Subjects: Animals; Antihypertensive Agents - pharmacology; Biological and medical sciences; Eye; Female; Genotype; Intraocular Pressure - drug effects; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Pharmacology. Drug treatments; Polymerase Chain Reaction; Prostaglandins F, Synthetic - pharmacology; Receptors, Prostaglandin - deficiency; Receptors, Prostaglandin - genetics; Antiglaucomatous agent; Vertebrata; Mammalia; Prostaglandin; Mouse; Animal; Rodentia; Ophthalmology; Latanoprost; Intraocular pressure

To determine whether latanoprost lowers IOP in prostaglandin FP receptor knockout mice. Mean IOP difference between treated and untreated fellow eyes was measured on three separate occasions, 2 hours after a 200-ng dose of latanoprost to the right eye of homozygous (n = 9) and heterozygous (n = 15)...