mTORC1 activity is supported by spatial association with focal adhesions

• Published in: The Journal of cell biology Vol. 220; no. 5; p. 1
• Main Authors: Rabanal-Ruiz, Yoana, Byron, Adam, Wirth, Alexander, Madsen, Ralitsa, Sedlackova, Lucia, Hewitt, Graeme, Nelson, Glyn, Stingele, Julian, Wills, Jimi C, Zhang, Tong, Zeug, André, Fässler, Reinhard, Vanhaesebroeck, Bart, Maddocks, Oliver D K, Ponimaskin, Evgeni, Carroll, Bernadette, Korolchuk, Viktor I
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 03.05.2021
• Subjects: Amino acids; Amino Acids - metabolism; Animals; Cell Line; Cell Line, Tumor; Cell Membrane - metabolism; Cell Signaling; Focal Adhesions - metabolism; Growth factors; HeLa Cells; Humans; Intracellular Membranes - metabolism; Localization; Lysosomes; Lysosomes - metabolism; Mechanistic Target of Rapamycin Complex 1 - metabolism; Membranes; Metabolism; Mice; Rapamycin; Signal Transduction - physiology; TOR protein; Translocation

The mammalian target of rapamycin complex 1 (mTORC1) integrates mitogenic and stress signals to control growth and metabolism. Activation of mTORC1 by amino acids and growth factors involves recruitment of the complex to the lysosomal membrane and is further supported by lysosome distribution to the...