FOXM1 Promotes Malignant Proliferation of Esophageal Squamous Cell Carcinoma Through Transcriptional Activating CDC6

• Published in: DNA and cell biology Vol. 41; no. 7; p. 671
• Main Authors: Chen, Xiongfeng, Chen, Jingbo, Yu, Xunbin, Lin, Guishan, Chen, Ting
• Format: Journal Article
• Language: English
• Published: United States 01.07.2022
• Subjects: Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; Cell Line, Tumor; Cell Movement; Cell Proliferation - genetics; Esophageal Neoplasms - genetics; Esophageal Neoplasms - pathology; Esophageal Squamous Cell Carcinoma - genetics; Esophageal Squamous Cell Carcinoma - metabolism; Esophageal Squamous Cell Carcinoma - pathology; Forkhead Box Protein M1 - genetics; Forkhead Box Protein M1 - metabolism; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Invasiveness - genetics; Nuclear Proteins - genetics; esophageal squamous cell carcinoma; tumor proliferation; CDC6; FOXM1

Forkhead box M1 (FOXM1) is a proliferative transcription factor and plays a vital role in many cancers. However, the function and molecular mechanism of FOXM1 in esophageal squamous cell carcinoma (ESCC) remain poorly understood. Hence, we aim to clarify the molecular basis of FOXM1-mediated ESCC pr...