Tempting fate: BMP signals for cardiac morphogenesis
Heart muscle cell specification (cardiac myogenesis) and creating the four-chambered heart (cardiac morphogenesis) are subject to regulation, in certain model organisms, by bone morphogenetic proteins and their receptors. Extrapolation to mammals from organisms that develop outside the mother (flies...
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| Published in | Cytokine & growth factor reviews Vol. 14; no. 1; pp. 1 - 4 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2003
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1359-6101 |
| DOI | 10.1016/S1359-6101(02)00053-9 |
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| Abstract | Heart muscle cell specification (cardiac myogenesis) and creating the four-chambered heart (cardiac morphogenesis) are subject to regulation, in certain model organisms, by bone morphogenetic proteins and their receptors. Extrapolation to mammals from organisms that develop outside the mother (flies, fish, frogs, and avians) has been confounded by very early lethality—at gastrulation—of many null alleles needed to prove cause–effect relations in this pathway. Here, we describe the use of lineage- or compartment-restricted null alleles as well as hypomorphic alleles, which circumvent these limitations and pinpoint novel essential functions for the bone morphogenetic protein cascade in mammalian cardiac development. |
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| AbstractList | Heart muscle cell specification (cardiac myogenesis) and creating the four-chambered heart (cardiac morphogenesis) are subject to regulation, in certain model organisms, by bone morphogenetic proteins and their receptors. Extrapolation to mammals from organisms that develop outside the mother (flies, fish, frogs, and avians) has been confounded by very early lethality-at gastrulation-of many null alleles needed to prove cause-effect relations in this pathway. Here, we describe the use of lineage- or compartment-restricted null alleles as well as hypomorphic alleles, which circumvent these limitations and pinpoint novel essential functions for the bone morphogenetic protein cascade in mammalian cardiac development.Heart muscle cell specification (cardiac myogenesis) and creating the four-chambered heart (cardiac morphogenesis) are subject to regulation, in certain model organisms, by bone morphogenetic proteins and their receptors. Extrapolation to mammals from organisms that develop outside the mother (flies, fish, frogs, and avians) has been confounded by very early lethality-at gastrulation-of many null alleles needed to prove cause-effect relations in this pathway. Here, we describe the use of lineage- or compartment-restricted null alleles as well as hypomorphic alleles, which circumvent these limitations and pinpoint novel essential functions for the bone morphogenetic protein cascade in mammalian cardiac development. Heart muscle cell specification (cardiac myogenesis) and creating the four-chambered heart (cardiac morphogenesis) are subject to regulation, in certain model organisms, by bone morphogenetic proteins and their receptors. Extrapolation to mammals from organisms that develop outside the mother (flies, fish, frogs, and avians) has been confounded by very early lethality—at gastrulation—of many null alleles needed to prove cause–effect relations in this pathway. Here, we describe the use of lineage- or compartment-restricted null alleles as well as hypomorphic alleles, which circumvent these limitations and pinpoint novel essential functions for the bone morphogenetic protein cascade in mammalian cardiac development. |
| Author | Lyons, Karen M Gaussin, Vinciane Schneider, Michael D |
| Author_xml | – sequence: 1 givenname: Michael D surname: Schneider fullname: Schneider, Michael D email: michaels@bcm.tmc.edu organization: Departments of Medicine, Molecular and Cellular Biology, and Molecular Physiology and Biophysics, Center for Cardiovascular Development, Baylor College of Medicine, One Baylor Plaza, Room 506D, Houston, TX 77030, USA – sequence: 2 givenname: Vinciane surname: Gaussin fullname: Gaussin, Vinciane organization: Cardiovascular Research Institute, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA – sequence: 3 givenname: Karen M surname: Lyons fullname: Lyons, Karen M organization: Departments of Biological Chemistry, Molecular, Cell, and Developmental Biology, and Orthopedic Surgery, University of California, Los Angeles, CA 90095, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12485614$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/S0092-8674(01)00275-6 10.1006/dbio.2000.9670 10.1073/pnas.042390499 10.1038/73557 10.1006/dbio.2001.0284 10.1242/dev.126.18.4005 10.1038/35101500 10.1101/gad.13.2.142 10.1242/dev.124.21.4373 10.1002/(SICI)1526-968X(200002)26:2<113::AID-GENE3>3.0.CO;2-2 10.1101/gad.9.24.3027 10.1016/S1359-6101(97)00036-1 10.1242/dev.128.18.3609 10.1038/374464a0 10.1016/S0925-4773(01)00500-7 10.1242/dev.126.8.1631 10.1016/S0092-8674(00)00121-5 10.1161/01.RES.88.6.587 10.1006/dbio.2002.0731 10.1073/pnas.98.3.1047 10.1101/gad.11.4.451 10.1016/S0014-5793(99)00869-8 10.1242/dev.126.23.5195 10.1006/bbrc.1997.6816 10.1242/dev.122.10.2977 10.1006/dbio.2002.0637 10.1002/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B 10.1128/MCB.19.10.7096 10.1006/dbio.2002.0603 10.1242/dev.126.11.2551 10.1242/dev.126.8.1753 10.1016/S0925-4773(98)00221-4 10.1038/79148 10.1006/dbio.2002.0604 10.1074/jbc.M111023200 10.1038/4887 10.1073/pnas.191217898 10.1006/dbio.2001.0291 |
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| Keywords | Bone morphogenetic proteins Transforming growth factor-beta Receptors Cre/lox ALK3 Mouse genetics |
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| References | Beppu, Kawabata, Hamamoto (BIB11) 2000; 221 Kawabata, Imamura, Miyazono (BIB9) 1998; 9 Nagy (BIB22) 2000; 26 Paria, Ma, Tan (BIB2) 2001; 98 Massague, Blain, Lo (BIB8) 2000; 103 Guimond, Sulea, Pepin, O’Connor-McCourt (BIB33) 1999; 456 Tallquist, Soriano (BIB26) 2000; 26 Condorelli, Borello, De Angelis (BIB39) 2001; 98 Rossant, McMahon (BIB21) 1999; 13 Korchynskyi, ten Dijke (BIB35) 2002; 277 Schultheiss, Burch, Lassar (BIB20) 1997; 11 Monzen, Shiojima, Hiroi (BIB4) 1999; 19 Solloway, Robertson (BIB6) 1999; 126 Neuhaus, Rosen, Thies (BIB7) 1999; 80 Greenwald, Fischer, Vale, Choe (BIB32) 1999; 6 Minamino, Gaussin, DeMayo, Schneider (BIB38) 2001; 88 Davis, Edwards, Juraszek (BIB25) 2001; 108 Ray, Wharton (BIB1) 2001; 104 Lien, McAnally, Richardson, Olson (BIB36) 2002; 244 Ramsdell, Yost (BIB19) 1999; 126 Weaver, Yingling, Dunn, Bellusci, Hogan (BIB30) 1999; 126 Zhang, Bradley (BIB13) 1996; 122 Miura, Tallquist, Soriano, Mishina (BIB27) 2002; 247 Gu, Reynolds, Song (BIB12) 1999; 126 Liberatore, Searcy-Schrick, Vincent, Yutzey (BIB37) 2002; 244 Allen, Bogardi, Barlow (BIB28) 2001; 235 Chen, Yee, Dains (BIB31) 2000; 24 Gurdon, Bourillot (BIB16) 2001; 413 Gaussin, Van De Putte, Mishina (BIB23) 2002; 99 Tremblay, Dunn, Robertson (BIB15) 2001; 128 Chang, Huylebroeck, Verschueren (BIB14) 1999; 126 Chen, van Eeden, Warren (BIB18) 1997; 124 Karsenty G. In: Canalis E, editor. Skeletal growth factors. Philadelphia: Lippincot Williams & Wilkens, 2000. p. 291–8. Frasch (BIB17) 1995; 374 Nakajima, Yamagishi, Ando, Nakamura (BIB29) 2002; 245 Kim, Robertson, Solloway (BIB5) 2001; 235 Mishina, Suzuki, Ueno, Behringer (BIB10) 1995; 9 Camenisch, Molin, Person (BIB24) 2002; 248 Beppu, Minowa, Miyazono, Kawabata (BIB34) 1997; 235 Scott (BIB40) 2000; 26 Solloway (10.1016/S1359-6101(02)00053-9_BIB6) 1999; 126 Scott (10.1016/S1359-6101(02)00053-9_BIB40) 2000; 26 Korchynskyi (10.1016/S1359-6101(02)00053-9_BIB35) 2002; 277 Frasch (10.1016/S1359-6101(02)00053-9_BIB17) 1995; 374 Allen (10.1016/S1359-6101(02)00053-9_BIB28) 2001; 235 Ray (10.1016/S1359-6101(02)00053-9_BIB1) 2001; 104 Chen (10.1016/S1359-6101(02)00053-9_BIB18) 1997; 124 Zhang (10.1016/S1359-6101(02)00053-9_BIB13) 1996; 122 Ramsdell (10.1016/S1359-6101(02)00053-9_BIB19) 1999; 126 Tallquist (10.1016/S1359-6101(02)00053-9_BIB26) 2000; 26 Minamino (10.1016/S1359-6101(02)00053-9_BIB38) 2001; 88 Nagy (10.1016/S1359-6101(02)00053-9_BIB22) 2000; 26 Nakajima (10.1016/S1359-6101(02)00053-9_BIB29) 2002; 245 Chen (10.1016/S1359-6101(02)00053-9_BIB31) 2000; 24 Massague (10.1016/S1359-6101(02)00053-9_BIB8) 2000; 103 Beppu (10.1016/S1359-6101(02)00053-9_BIB11) 2000; 221 Schultheiss (10.1016/S1359-6101(02)00053-9_BIB20) 1997; 11 Paria (10.1016/S1359-6101(02)00053-9_BIB2) 2001; 98 Condorelli (10.1016/S1359-6101(02)00053-9_BIB39) 2001; 98 Greenwald (10.1016/S1359-6101(02)00053-9_BIB32) 1999; 6 Tremblay (10.1016/S1359-6101(02)00053-9_BIB15) 2001; 128 Weaver (10.1016/S1359-6101(02)00053-9_BIB30) 1999; 126 Beppu (10.1016/S1359-6101(02)00053-9_BIB34) 1997; 235 Liberatore (10.1016/S1359-6101(02)00053-9_BIB37) 2002; 244 Guimond (10.1016/S1359-6101(02)00053-9_BIB33) 1999; 456 Monzen (10.1016/S1359-6101(02)00053-9_BIB4) 1999; 19 Kawabata (10.1016/S1359-6101(02)00053-9_BIB9) 1998; 9 Miura (10.1016/S1359-6101(02)00053-9_BIB27) 2002; 247 Chang (10.1016/S1359-6101(02)00053-9_BIB14) 1999; 126 Rossant (10.1016/S1359-6101(02)00053-9_BIB21) 1999; 13 Davis (10.1016/S1359-6101(02)00053-9_BIB25) 2001; 108 Kim (10.1016/S1359-6101(02)00053-9_BIB5) 2001; 235 10.1016/S1359-6101(02)00053-9_BIB3 Lien (10.1016/S1359-6101(02)00053-9_BIB36) 2002; 244 Gurdon (10.1016/S1359-6101(02)00053-9_BIB16) 2001; 413 Gaussin (10.1016/S1359-6101(02)00053-9_BIB23) 2002; 99 Camenisch (10.1016/S1359-6101(02)00053-9_BIB24) 2002; 248 Gu (10.1016/S1359-6101(02)00053-9_BIB12) 1999; 126 Mishina (10.1016/S1359-6101(02)00053-9_BIB10) 1995; 9 Neuhaus (10.1016/S1359-6101(02)00053-9_BIB7) 1999; 80 |
| References_xml | – volume: 98 start-page: 10733 year: 2001 end-page: 10738 ident: BIB39 article-title: Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 126 start-page: 4005 year: 1999 end-page: 4015 ident: BIB30 article-title: Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development publication-title: Development – volume: 128 start-page: 3609 year: 2001 end-page: 3621 ident: BIB15 article-title: Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation publication-title: Development – volume: 126 start-page: 5195 year: 1999 end-page: 5205 ident: BIB19 article-title: Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway publication-title: Development – volume: 99 start-page: 2878 year: 2002 end-page: 2883 ident: BIB23 article-title: Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3 publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 456 start-page: 79 year: 1999 end-page: 84 ident: BIB33 article-title: Mapping of putative binding sites on the ectodomain of the type II TGF-beta receptor by scanning-deletion mutagenesis and knowledge-based modeling publication-title: FEBS Lett. – volume: 13 start-page: 142 year: 1999 end-page: 145 ident: BIB21 article-title: “Cre”-ating mouse mutants—a meeting review on conditional mouse genetics publication-title: Gen. Dev. – volume: 235 start-page: 499 year: 1997 end-page: 504 ident: BIB34 article-title: cDNA cloning and genomic organization of the mouse BMP type II receptor publication-title: Biochem. Biophys. Res. Commun. – volume: 235 start-page: 98 year: 2001 end-page: 109 ident: BIB28 article-title: Misexpression of noggin leads to septal defects in the outflow tract of the chick heart publication-title: Dev. Biol. – volume: 80 start-page: 181 year: 1999 end-page: 184 ident: BIB7 article-title: Heart specific expression of mouse BMP-10, a novel member of the TGF-beta superfamily publication-title: Mech. Dev. – volume: 126 start-page: 1753 year: 1999 end-page: 1768 ident: BIB6 article-title: Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup publication-title: Development – volume: 277 start-page: 4883 year: 2002 end-page: 4891 ident: BIB35 article-title: Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter publication-title: J. Biol. Chem. – volume: 98 start-page: 1047 year: 2001 end-page: 1052 ident: BIB2 article-title: Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors publication-title: Proc. Natl. Acad. Sci. U.S.A. – volume: 6 start-page: 18 year: 1999 end-page: 22 ident: BIB32 article-title: Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase publication-title: Nat. Struct. Biol. – volume: 26 start-page: 113 year: 2000 end-page: 115 ident: BIB26 article-title: Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function publication-title: Genesis – volume: 122 start-page: 2977 year: 1996 end-page: 2986 ident: BIB13 article-title: Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development publication-title: Development – volume: 244 start-page: 243 year: 2002 end-page: 256 ident: BIB37 article-title: Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region publication-title: Dev. Biol. – volume: 413 start-page: 797 year: 2001 end-page: 803 ident: BIB16 article-title: Morphogen gradient interpretation publication-title: Nature – volume: 221 start-page: 249 year: 2000 end-page: 258 ident: BIB11 article-title: BMP type II receptor is required for gastrulation and early development of mouse embryos publication-title: Dev. Biol. – volume: 124 start-page: 4373 year: 1997 end-page: 4382 ident: BIB18 article-title: Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish publication-title: Development – volume: 374 start-page: 464 year: 1995 end-page: 467 ident: BIB17 article-title: Induction of visceral and cardiac mesoderm by ectodermal dpp in the early Drosophila embryo publication-title: Nature – volume: 104 start-page: 801 year: 2001 end-page: 804 ident: BIB1 article-title: Twisted perspective: new insights into extracellular modulation of BMP signaling during development publication-title: Cell – volume: 19 start-page: 7096 year: 1999 end-page: 7105 ident: BIB4 article-title: Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4 publication-title: Mol. Cell. Biol. – volume: 26 start-page: 99 year: 2000 end-page: 109 ident: BIB22 article-title: Cre recombinase: the universal reagent for genome tailoring publication-title: Genesis – volume: 26 start-page: 3 year: 2000 end-page: 4 ident: BIB40 article-title: Pulling apart pulmonary hypertension publication-title: Nat. Genet. – volume: 248 start-page: 170 year: 2002 end-page: 181 ident: BIB24 article-title: Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis publication-title: Dev. Biol. – volume: 245 start-page: 291 year: 2002 end-page: 303 ident: BIB29 article-title: Significance of bone morphogenetic protein-4 function in the initial myofibrillogenesis of chick cardiogenesis publication-title: Dev. Biol. – volume: 126 start-page: 1631 year: 1999 end-page: 1642 ident: BIB14 article-title: Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects publication-title: Development – volume: 11 start-page: 451 year: 1997 end-page: 462 ident: BIB20 article-title: A role for bone morphogenetic proteins in the induction of cardiac myogenesis publication-title: Gen. Dev. – volume: 24 start-page: 314 year: 2000 end-page: 317 ident: BIB31 article-title: Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells publication-title: Nat. Genet. – reference: Karsenty G. In: Canalis E, editor. Skeletal growth factors. Philadelphia: Lippincot Williams & Wilkens, 2000. p. 291–8. – volume: 126 start-page: 2551 year: 1999 end-page: 2561 ident: BIB12 article-title: The type I serine threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo publication-title: Development – volume: 235 start-page: 449 year: 2001 end-page: 466 ident: BIB5 article-title: Bmp6 and bmp7 are required for cushion formation and septation in the developing mouse heart publication-title: Dev. Biol. – volume: 247 start-page: 505 year: 2002 ident: BIB27 article-title: BMP signaling is important for mesoderm induction and germ layer development in mouse embryogenesis publication-title: Dev. Biol. – volume: 88 start-page: 587 year: 2001 end-page: 592 ident: BIB38 article-title: Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein publication-title: Circ. Res. – volume: 9 start-page: 3027 year: 1995 end-page: 3037 ident: BIB10 article-title: BMPR encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis publication-title: Gen. Dev. – volume: 9 start-page: 49 year: 1998 end-page: 61 ident: BIB9 article-title: Signal transduction by bone morphogenetic proteins publication-title: Cytokine Growth Factor Rev. – volume: 103 start-page: 295 year: 2000 end-page: 309 ident: BIB8 article-title: TGFbeta signaling in growth control, cancer, and heritable disorders publication-title: Cell – volume: 108 start-page: 105 year: 2001 end-page: 119 ident: BIB25 article-title: A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system publication-title: Mech. Dev. – volume: 244 start-page: 257 year: 2002 end-page: 266 ident: BIB36 article-title: Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site publication-title: Dev. Biol. – volume: 104 start-page: 801 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB1 article-title: Twisted perspective: new insights into extracellular modulation of BMP signaling during development publication-title: Cell doi: 10.1016/S0092-8674(01)00275-6 – volume: 221 start-page: 249 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB11 article-title: BMP type II receptor is required for gastrulation and early development of mouse embryos publication-title: Dev. Biol. doi: 10.1006/dbio.2000.9670 – volume: 99 start-page: 2878 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB23 article-title: Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3 publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.042390499 – volume: 24 start-page: 314 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB31 article-title: Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells publication-title: Nat. Genet. doi: 10.1038/73557 – volume: 235 start-page: 449 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB5 article-title: Bmp6 and bmp7 are required for cushion formation and septation in the developing mouse heart publication-title: Dev. Biol. doi: 10.1006/dbio.2001.0284 – volume: 126 start-page: 4005 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB30 article-title: Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development publication-title: Development doi: 10.1242/dev.126.18.4005 – volume: 413 start-page: 797 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB16 article-title: Morphogen gradient interpretation publication-title: Nature doi: 10.1038/35101500 – volume: 13 start-page: 142 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB21 article-title: “Cre”-ating mouse mutants—a meeting review on conditional mouse genetics publication-title: Gen. Dev. doi: 10.1101/gad.13.2.142 – volume: 124 start-page: 4373 year: 1997 ident: 10.1016/S1359-6101(02)00053-9_BIB18 article-title: Left-right pattern of cardiac BMP4 may drive asymmetry of the heart in zebrafish publication-title: Development doi: 10.1242/dev.124.21.4373 – volume: 26 start-page: 113 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB26 article-title: Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function publication-title: Genesis doi: 10.1002/(SICI)1526-968X(200002)26:2<113::AID-GENE3>3.0.CO;2-2 – volume: 9 start-page: 3027 year: 1995 ident: 10.1016/S1359-6101(02)00053-9_BIB10 article-title: BMPR encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis publication-title: Gen. Dev. doi: 10.1101/gad.9.24.3027 – volume: 9 start-page: 49 year: 1998 ident: 10.1016/S1359-6101(02)00053-9_BIB9 article-title: Signal transduction by bone morphogenetic proteins publication-title: Cytokine Growth Factor Rev. doi: 10.1016/S1359-6101(97)00036-1 – volume: 128 start-page: 3609 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB15 article-title: Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation publication-title: Development doi: 10.1242/dev.128.18.3609 – volume: 374 start-page: 464 year: 1995 ident: 10.1016/S1359-6101(02)00053-9_BIB17 article-title: Induction of visceral and cardiac mesoderm by ectodermal dpp in the early Drosophila embryo publication-title: Nature doi: 10.1038/374464a0 – volume: 108 start-page: 105 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB25 article-title: A GATA-6 gene heart-region-specific enhancer provides a novel means to mark and probe a discrete component of the mouse cardiac conduction system publication-title: Mech. Dev. doi: 10.1016/S0925-4773(01)00500-7 – volume: 126 start-page: 1631 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB14 article-title: Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects publication-title: Development doi: 10.1242/dev.126.8.1631 – ident: 10.1016/S1359-6101(02)00053-9_BIB3 – volume: 103 start-page: 295 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB8 article-title: TGFbeta signaling in growth control, cancer, and heritable disorders publication-title: Cell doi: 10.1016/S0092-8674(00)00121-5 – volume: 88 start-page: 587 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB38 article-title: Inducible gene targeting in postnatal myocardium by cardiac-specific expression of a hormone-activated Cre fusion protein publication-title: Circ. Res. doi: 10.1161/01.RES.88.6.587 – volume: 248 start-page: 170 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB24 article-title: Temporal and distinct TGFbeta ligand requirements during mouse and avian endocardial cushion morphogenesis publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0731 – volume: 98 start-page: 1047 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB2 article-title: Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.98.3.1047 – volume: 11 start-page: 451 year: 1997 ident: 10.1016/S1359-6101(02)00053-9_BIB20 article-title: A role for bone morphogenetic proteins in the induction of cardiac myogenesis publication-title: Gen. Dev. doi: 10.1101/gad.11.4.451 – volume: 456 start-page: 79 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB33 article-title: Mapping of putative binding sites on the ectodomain of the type II TGF-beta receptor by scanning-deletion mutagenesis and knowledge-based modeling publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)00869-8 – volume: 126 start-page: 5195 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB19 article-title: Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway publication-title: Development doi: 10.1242/dev.126.23.5195 – volume: 235 start-page: 499 year: 1997 ident: 10.1016/S1359-6101(02)00053-9_BIB34 article-title: cDNA cloning and genomic organization of the mouse BMP type II receptor publication-title: Biochem. Biophys. Res. Commun. doi: 10.1006/bbrc.1997.6816 – volume: 122 start-page: 2977 year: 1996 ident: 10.1016/S1359-6101(02)00053-9_BIB13 article-title: Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development publication-title: Development doi: 10.1242/dev.122.10.2977 – volume: 245 start-page: 291 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB29 article-title: Significance of bone morphogenetic protein-4 function in the initial myofibrillogenesis of chick cardiogenesis publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0637 – volume: 26 start-page: 99 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB22 article-title: Cre recombinase: the universal reagent for genome tailoring publication-title: Genesis doi: 10.1002/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B – volume: 19 start-page: 7096 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB4 article-title: Bone morphogenetic proteins induce cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4 publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.19.10.7096 – volume: 244 start-page: 257 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB36 article-title: Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0603 – volume: 126 start-page: 2551 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB12 article-title: The type I serine threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo publication-title: Development doi: 10.1242/dev.126.11.2551 – volume: 126 start-page: 1753 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB6 article-title: Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup publication-title: Development doi: 10.1242/dev.126.8.1753 – volume: 80 start-page: 181 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB7 article-title: Heart specific expression of mouse BMP-10, a novel member of the TGF-beta superfamily publication-title: Mech. Dev. doi: 10.1016/S0925-4773(98)00221-4 – volume: 26 start-page: 3 year: 2000 ident: 10.1016/S1359-6101(02)00053-9_BIB40 article-title: Pulling apart pulmonary hypertension publication-title: Nat. Genet. doi: 10.1038/79148 – volume: 247 start-page: 505 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB27 article-title: BMP signaling is important for mesoderm induction and germ layer development in mouse embryogenesis publication-title: Dev. Biol. – volume: 244 start-page: 243 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB37 article-title: Nkx-2.5 gene induction in mice is mediated by a Smad consensus regulatory region publication-title: Dev. Biol. doi: 10.1006/dbio.2002.0604 – volume: 277 start-page: 4883 year: 2002 ident: 10.1016/S1359-6101(02)00053-9_BIB35 article-title: Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111023200 – volume: 6 start-page: 18 year: 1999 ident: 10.1016/S1359-6101(02)00053-9_BIB32 article-title: Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase publication-title: Nat. Struct. Biol. doi: 10.1038/4887 – volume: 98 start-page: 10733 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB39 article-title: Cardiomyocytes induce endothelial cells to trans-differentiate into cardiac muscle: implications for myocardium regeneration publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.191217898 – volume: 235 start-page: 98 year: 2001 ident: 10.1016/S1359-6101(02)00053-9_BIB28 article-title: Misexpression of noggin leads to septal defects in the outflow tract of the chick heart publication-title: Dev. Biol. doi: 10.1006/dbio.2001.0291 |
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| SubjectTerms | ALK3 Animals Bone Morphogenetic Protein Receptors Bone morphogenetic proteins Bone Morphogenetic Proteins - genetics Bone Morphogenetic Proteins - metabolism Cre/lox Gene Targeting Heart - growth & development Morphogenesis Mouse genetics Receptors Receptors, Growth Factor - genetics Receptors, Growth Factor - metabolism Signal Transduction - physiology Transforming growth factor-beta |
| Title | Tempting fate: BMP signals for cardiac morphogenesis |
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