A viral kinase mimics S6 kinase to enhance cell proliferation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 28; pp. 7876 - 7881
• Main Authors: Bhatt, Aadra Prashant, Wong, Jason P., Weinberg, Marc S., Host, Kurtis M., Giffin, Louise C., Buijnink, Joshua, van Dijk, Evert, Izumiya, Yoshihiro, Kung, Hsing-jien, Temple, Brenda R. S., Damania, Blossom
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.07.2016
• Subjects: Biological Sciences; Computer Simulation; HEK293 Cells; Herpesvirus 8, Human - enzymology; Human Umbilical Vein Endothelial Cells; Humans; Models, Molecular; Ribosomal Protein S6 Kinases, 70-kDa - chemistry; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Substrate Specificity; Viral Proteins - chemistry; Viral Proteins - metabolism; ORF36; S6K; KSHV; viral protein kinase; cell signaling

Viruses depend upon the host cell for manufacturing components of progeny virions. To mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate protein synthesis through a variety of mechanisms. We report that the viral protein kinase (vPK) encoded by open reading fra...