Flavor Constituents in Cola Drinks Induce Hepatic DNA Adducts in Adult and Fetal Mice

• Published in: Biochemical and biophysical research communications Vol. 192; no. 1; pp. 61 - 68
• Main Authors: Randerath, K., Putman, K.L., Randerath, E.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 15.04.1993; Elsevier
• Subjects: adn; adulte; adultos; adults; Animals; Benzyl Compounds; Beverages - toxicity; Biological and medical sciences; boisson non alcoolisee; carcinogenos; carcinogens; compose de la flaveur; compuestos del sabor; desinfectant; desinfectantes; Dioxolanes - toxicity; disinfectants; dna; DNA Damage; Female; feto; Fetus; Flavoring Agents - toxicity; flavour compounds; foetus; foie; Food toxicology; gaseosas; higado; liver; Liver - drug effects; Liver - embryology; Liver - metabolism; mace; macis; Medical sciences; Mice; noix muscade; nuez moscada; nutmegs; Pregnancy; Pyrogallol - analogs & derivatives; raton; Safrole - toxicity; soft drinks; souris; Spices; substance cancerigene; toxicidad; toxicite; toxicity; Toxicology; toxinas; toxine; toxins; Non alcoholic beverage; Cola; Nutmeg; Toxicity; Liver; Rodentia; Vertebrata; Mace; Mammalia; Mouse; Dicotyledones; Sterculiaceae; DNA; Angiospermae; Adult animal; Fetus; Spermatophyta; Aromatic compound; Molecular adduct

Mice given one of several widely consumed cola drinks in place of drinking water for up to 8 weeks developed significant levels of covalent liver DNA adducts in a time dependent manner, as measured by 32P-postlabeling. These adducts were not detected in mice given tap water or one of 3 non-cola beve...