Protein kinase Cε, which sensitizes skin to sun's UV radiation-induced cutaneous damage and development of squamous cell carcinomas, associates with stat3

• Published in: Cancer research (Chicago, Ill.) Vol. 67; no. 3; pp. 1385 - 1394
• Main Authors: AZIZ, Moammir H, MANOHARAN, Herbert T, VERMA, Ajit K
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.02.2007
• Subjects: Animals; Antineoplastic agents; Biological and medical sciences; Carcinoma, Squamous Cell - enzymology; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pharmacology. Drug treatments; Phosphorylation; Protein Kinase C-epsilon - biosynthesis; Protein Kinase C-epsilon - genetics; Protein Kinase C-epsilon - metabolism; Skin - enzymology; Skin - radiation effects; Skin Neoplasms - enzymology; Skin Neoplasms - etiology; Skin Neoplasms - genetics; Skin Neoplasms - metabolism; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Tumors; Ultraviolet Rays; Squamous cell carcinoma; Enzyme; Protein kinase; Toxicity; Transferases; Transcription factor STAT3; Skin; Malignant tumor; Sun; Radiation damage

Chronic exposure to UV radiation (UVR) is the major etiologic factor in the development of human skin cancers including squamous cell carcinoma (SCC). We have shown that protein kinase C(epsilon) (PKC(epsilon)), a Ca(2+)-independent, phospholipid-dependent serine/threonine kinase, is an endogenous p...