Design and synthesis of various 1,3,4-oxadiazoles as AChE and LOX enzyme inhibitors

• Published in: Heterocyclic Communications Vol. 29; no. 1; pp. 149 - 60
• Main Authors: Iqbal Javed, Mallhi Ali Imran, ur Rehman Aziz, Al-Mijalli Samiah H., un-Nisa Mehr, Zafar Fatiqa, Shahzad Sohail, Rasool Shahid, Iqbal Munawar, Shah Syed Adnan Ali
• Format: Journal Article
• Language: English
• Published: Berlin Walter de Gruyter GmbH 15.11.2023; De Gruyter
• Subjects: 1,3,4-oxadiazole; acetyl cholinesterase; Chemical synthesis; Enzymes; In vivo methods and tests; Infrared spectroscopy; lipoxygenase; Liquid oxygen; Molecular docking; Molecular structure; NMR; Nuclear magnetic resonance; Oxadiazoles; Pharmacology; Physostigmine; Piperidine; Spectrum analysis; urease

N-Substituted-2-propanamide analogues of 1,3,4-oxadiazole have been synthesized using a multi-step synthetic protocol to explore new therapeutic anti-enzymatic agents. Herein, we have merged sulfonyl, piperidine, oxadiazole and amide into a single unit to synthesize a library of unique compounds, 8a...