miRNA and mRNA Signatures in Human Acute Kidney Injury Tissue

• Published in: The American journal of pathology Vol. 195; no. 1; pp. 102 - 114
• Main Authors: Janosevic, Danielle, De Luca, Thomas, Melo Ferreira, Ricardo, Gisch, Debora L., Cheng, Ying-Hua, Hato, Takashi, Luo, Jinghui, Yang, Yingbao, Hodgin, Jeffrey B., Phillips, Carrie L., Dagher, Pierre C., Eadon, Michael T.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2025
• Subjects: Acute Kidney Injury - genetics; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Adult; Aged; Epithelial-Mesenchymal Transition - genetics; Female; Gene Expression Profiling - methods; Humans; Kidney - metabolism; Kidney - pathology; Male; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; RNA, Messenger - genetics; RNA, Messenger - metabolism; Transcriptome - genetics

Acute kidney injury (AKI) is an important contributor to the development of chronic kidney disease (CKD). There is a need to understand molecular mediators that drive recovery and progression to CKD. In particular, the regulatory role of miRNAs in AKI is poorly understood. Herein, miRNA and mRNA seq...