State-dependent and site-directed photodynamic transformation of HCN2 channel by singlet oxygen

• Published in: The Journal of general physiology Vol. 143; no. 5; pp. 633 - 644
• Main Authors: Gao, Weihua, Su, Zhuocheng, Liu, Qinglian, Zhou, Lei
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.05.2014; The Rockefeller University Press
• Subjects: Action Potentials; Amino Acid Sequence; Animals; Cells; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - chemistry; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism; Ion Channel Gating; Mice; Molecular Sequence Data; Molecules; Mutation; Oxidation; Oxygen; Potassium Channels - chemistry; Potassium Channels - genetics; Potassium Channels - metabolism; Protein Structure, Tertiary; Proteins; Singlet Oxygen - metabolism; Xenopus

Singlet oxygen (1O2), which is generated through metabolic reactions and oxidizes numerous biological molecules, has been a useful tool in basic research and clinical practice. However, its role as a signaling factor, as well as a mechanistic understanding of the oxidation process, remains poorly un...