Bacterially-Derived Nanocells for Tumor-Targeted Delivery of Chemotherapeutics and Cell Cycle Inhibitors

• Published in: Cell cycle (Georgetown, Tex.) Vol. 6; no. 17; pp. 2099 - 2105
• Main Authors: MacDiarmid, Jennifer A., Madrid-Weiss, Jocelyn, Amaro-Mugridge, Nancy B., Phillips, Leo, Brahmbhatt, Himanshu
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.09.2007
• Subjects: Animals; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Bacteria - cytology; Binding; Biology; Bioscience; Calcium; Cancer; Cell; Cell Cycle - drug effects; Cycle; Dogs; Drug Delivery Systems; Drug Packaging; Landes; Lymphoma, Non-Hodgkin - drug therapy; Mice; Nanotechnology; Neoplasms - drug therapy; Organogenesis; Proteins

Chemotherapeutic drug therapy in cancer is seriously hampered by severe toxicity primarily due to indiscriminate drug distribution and consequent collateral damage to normal cells. Molecularly targeted drugs such as cell cycle inhibitors are being developed to achieve a higher degree of tumor cell s...