A Role for MAPK in Feedback Inhibition of Tcrb Recombination

• Published in: Journal of Immunology Vol. 176; no. 11; pp. 6824 - 6830
• Main Authors: Jackson, Annette M, Krangel, Michael S
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 01.06.2006
• Subjects: Adaptor Proteins, Signal Transducing - deficiency; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - physiology; Alleles; Animals; Chromatin - chemistry; Chromatin - genetics; Down-Regulation - genetics; Down-Regulation - immunology; Feedback, Physiological - genetics; Feedback, Physiological - immunology; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Humans; Membrane Proteins - deficiency; Membrane Proteins - genetics; Membrane Proteins - physiology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Phosphoproteins - deficiency; Phosphoproteins - genetics; Phosphoproteins - physiology; Protein Prenylation; Proto-Oncogene Proteins c-raf - genetics; Proto-Oncogene Proteins c-raf - physiology; Receptors, Antigen, T-Cell, alpha-beta - antagonists & inhibitors; Receptors, Antigen, T-Cell, alpha-beta - biosynthesis; Receptors, Antigen, T-Cell, alpha-beta - genetics; Signal Transduction - genetics; Signal Transduction - immunology; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; Thymus Gland - cytology; Thymus Gland - immunology; Thymus Gland - metabolism

The Tcrb locus is subject to a host of regulatory mechanisms that impart a strict cell and developmental stage-specific order to variable (V), diversity (D), and joining (J) gene segment recombination. The Tcrb locus is also regulated by allelic exclusion mechanisms, which restrict functional rearra...