Protective effect and mechanism of ginsenoside Rg1 in cerebral ischaemia-reperfusion injury in mice

• Published in: Biomedicine & pharmacotherapy Vol. 99; pp. 876 - 882
• Main Authors: Wang, Le, Zhao, Hong, Zhai, Zhen-zhen, Qu, Li-xin
• Format: Journal Article
• Language: English
• Published: France Elsevier Masson SAS 01.03.2018
• Subjects: Animals; Asp; BDNF; Blotting, Western; Brain Ischemia - drug therapy; Brain Ischemia - pathology; Brain-Derived Neurotrophic Factor - genetics; CA1 Region, Hippocampal - drug effects; Disease Models, Animal; Down-Regulation; Gene Expression Regulation - drug effects; Ginsenoside Rg1; Ginsenosides - pharmacology; Glu; IL-1β; Infarction, Middle Cerebral Artery - complications; Interleukin-1beta - genetics; Interleukin-6 - genetics; Ischaemia/reperfusion; Male; Mice; Mice, Inbred C57BL; Neuroprotective Agents - pharmacology; Reperfusion Injury - drug therapy; Reperfusion Injury - pathology; Tumor Necrosis Factor-alpha - genetics; Ginsenoside Rg1; Glu; Ischaemia/reperfusion; IL-1β; BDNF; Asp; IL-1?

Ginsenoside Rg1 is regarded as one of main bioactive compounds responsible for pharmaceutical actions of ginseng with little toxicity and has been shown to have possibly neuroprotective effects. However, the mechanism of its neuroprotection for acute ischemic stroke is still elusive. The purpose of...