Uptake of non-invasive prenatal testing (NIPT) and impact on invasive procedures in a tertiary referral center

• Published in: Archives of gynecology and obstetrics Vol. 292; no. 3; pp. 543 - 548
• Main Authors: Manegold-Brauer, Gwendolin, Berg, C., Flöck, A., Rüland, A., Gembruch, U., Geipel, A.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2015; Springer Nature B.V
• Subjects: Adult; Algorithms; Down Syndrome - diagnosis; Endocrinology; Female; Gynecology; Health risk assessment; Human Genetics; Humans; Maternal Age; Maternal Serum Screening Tests; Maternal-Fetal Medicine; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Pregnancy; Pregnancy Trimester, First; Prenatal Care - methods; Prenatal Diagnosis - methods; Retrospective Studies; Risk Factors; Sequence Analysis, DNA; Tertiary Care Centers; Ultrasonic imaging; Non-invasive prenatal testing; Trisomy 21; Prenatal counseling; Fetal aneuploidies; Cell-free fetal DNA; NIPT; NIPD

Purpose The introduction of non-invasive prenatal testing (NIPT) by isolation of cell-free fetal DNA from maternal blood is a new diagnostic option in prenatal care. The aim of the study was to investigate the algorithm of prenatal testing before and after the introduction of NIPT in a tertiary refe...