Copper in hepatocellular carcinoma： A double-edged sword with therapeutic potentials

• Published in: Cancer letters Vol. 571; p. 216348
• Main Authors: Wu, Zixin, Lv, Guishuai, Xing, Fuxue, Xiang, Wei, Ma, Yue, Feng, Qiyu, Yang, Wen, Wang, Hongyang
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.09.2023
• Subjects: Cancer therapy; Copper; Copper homeostasis; Cuproptosis; Hepatocellular carcinoma; Copper homeostasis; Hepatocellular carcinoma; Copper; Cuproptosis; Cancer therapy

Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ,...