Copper in hepatocellular carcinoma： A double-edged sword with therapeutic potentials

Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ,...

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Published inCancer letters Vol. 571; p. 216348
Main Authors Wu, Zixin, Lv, Guishuai, Xing, Fuxue, Xiang, Wei, Ma, Yue, Feng, Qiyu, Yang, Wen, Wang, Hongyang
Format Journal Article
LanguageEnglish
Published Ireland Elsevier B.V 01.09.2023
Subjects
Cancer therapy
Copper
Copper homeostasis
Cuproptosis
Hepatocellular carcinoma
Copper homeostasis
Hepatocellular carcinoma
Copper
Cuproptosis
Cancer therapy
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Abstract Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients. •The maintenance of copper homeostasis is essential for normal physiological functions.•Copper exhibits both promoting and inhibitory effects on the occurrence and development of liver cancer.•Cuproptosis holds broad application prospects in exploring new therapeutic targets and drug development for liver cancer.•Targeting cuproplasia by utilizing copper chelators and copper ion carriers could antagonize tumorigenesis.
AbstractList Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients.
Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients. •The maintenance of copper homeostasis is essential for normal physiological functions.•Copper exhibits both promoting and inhibitory effects on the occurrence and development of liver cancer.•Cuproptosis holds broad application prospects in exploring new therapeutic targets and drug development for liver cancer.•Targeting cuproplasia by utilizing copper chelators and copper ion carriers could antagonize tumorigenesis.
Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients.Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have demonstrated that copper is a double-edged sword, presenting both benefits and detriments to tumors. The liver is a metabolically active organ, and an imbalance of copper homeostasis can result in deleterious consequences to the liver. Hepatocellular carcinoma (HCC), the most common primary liver cancer, is a highly aggressive malignancy with limited viable therapeutic options. As research advances, the focus has shifted towards the relationships between copper and HCC. Innovatively, cuproplasia and cuproptosis have been proposed to depict copper-related cellular growth and death, providing new insights for HCC treatment. By summarizing the constantly elucidated molecular connections, this review discusses the mechanisms of copper in the pathogenesis, progression, and potential therapeutics of HCC. Additionally, we aim to tentatively provide a theoretical foundation and gospel for HCC patients.
ArticleNumber 216348
Author Xiang, Wei
Ma, Yue
Wu, Zixin
Yang, Wen
Wang, Hongyang
Feng, Qiyu
Xing, Fuxue
Lv, Guishuai
Author_xml – sequence: 1
  givenname: Zixin
  surname: Wu
  fullname: Wu, Zixin
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
– sequence: 2
  givenname: Guishuai
  surname: Lv
  fullname: Lv, Guishuai
  organization: International Co-operation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Institute/Hospital, Second Military Medical University, Shanghai, 200438, China
– sequence: 3
  givenname: Fuxue
  surname: Xing
  fullname: Xing, Fuxue
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
– sequence: 4
  givenname: Wei
  surname: Xiang
  fullname: Xiang, Wei
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
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  givenname: Yue
  surname: Ma
  fullname: Ma, Yue
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
– sequence: 6
  givenname: Qiyu
  surname: Feng
  fullname: Feng, Qiyu
  email: qiyu@icloud.com
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
– sequence: 7
  givenname: Wen
  surname: Yang
  fullname: Yang, Wen
  email: woodeasy66@hotmail.com
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
– sequence: 8
  givenname: Hongyang
  surname: Wang
  fullname: Wang, Hongyang
  email: hywangk@vip.sina.com
  organization: Cancer Research Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China
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Keywords Copper homeostasis
Hepatocellular carcinoma
Copper
Cuproptosis
Cancer therapy
Language English
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Snippet Copper is a necessary cofactor vital for maintaining biological functions, as well as participating in the development of cancer. A plethora of studies have...
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SubjectTerms Cancer therapy
Copper
Copper homeostasis
Cuproptosis
Hepatocellular carcinoma
Title Copper in hepatocellular carcinoma： A double-edged sword with therapeutic potentials
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https://dx.doi.org/10.1016/j.canlet.2023.216348
https://www.ncbi.nlm.nih.gov/pubmed/37567461
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