The N terminus of myosin-binding protein C extends toward actin filaments in intact cardiac muscle

• Published in: The Journal of general physiology Vol. 153; no. 3; p. 1
• Main Authors: Rahmanseresht, Sheema, Lee, Kyoung H, O'Leary, Thomas S, McNamara, James W, Sadayappan, Sakthivel, Robbins, Jeffrey, Warshaw, David M, Craig, Roger, Previs, Michael J
• Format: Journal Article
• Language: English
• Published: United States Rockefeller University Press 01.03.2021
• Subjects: Actin; Actin Cytoskeleton - metabolism; Animals; Biophysics; Cardiac muscle; Carrier Proteins - metabolism; Contraction and cell motility; Filaments; Fluorescence microscopy; Mice; Molecular physiology; Muscle contraction; Myocardium; Myocardium - metabolism; Myofilament Special Issue, 2020; Myosin; Myosin-binding protein C; Protein Binding; Protein C; Protein structure and dynamics; Proteins; Sarcomeres; Sarcomeres - metabolism

Myosin and actin filaments are highly organized within muscle sarcomeres. Myosin-binding protein C (MyBP-C) is a flexible, rod-like protein located within the C-zone of the sarcomere. The C-terminal domain of MyBP-C is tethered to the myosin filament backbone, and the N-terminal domains are postulat...