Repetitive Transcranial Magnetic Stimulation with Resting-State Network Targeting for Treatment-Resistant Depression in Traumatic Brain Injury: A Randomized, Controlled, Double-Blinded Pilot Study

• Published in: Journal of neurotrauma Vol. 36; no. 8; pp. 1361 - 1374
• Main Authors: Siddiqi, Shan H., Trapp, Nicholas T., Hacker, Carl D., Laumann, Timothy O., Kandala, Sridhar, Hong, Xin, Trillo, Ludwig, Shahim, Pashtun, Leuthardt, Eric C., Carter, Alexandre R., Brody, David L.
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 15.04.2019; Mary Ann Liebert, Inc., publishers
• Subjects: Adult; Brain Injuries, Traumatic - complications; Brain mapping; Brain Mapping - methods; Brain research; Clinical trials; Cortex (cingulate); Depressive Disorder, Treatment-Resistant - complications; Depressive Disorder, Treatment-Resistant - therapy; Double-Blind Method; Drug therapy; Female; Functional magnetic resonance imaging; Humans; Magnetic fields; Magnetic Resonance Imaging - methods; Male; Medicine; Mental depression; Middle Aged; Neural networks; Neuroimaging; Original; Patients; Physiology; Pilot Projects; Prefrontal cortex; Seizures; Stroke; Transcranial magnetic stimulation; Transcranial Magnetic Stimulation - methods; Traumatic brain injury; Treatment resistance; United States > US; Missouri; fMRI; TBI; depression; rTMS

Repetitive transcranial magnetic stimulation (rTMS) has demonstrated antidepressant efficacy but has limited evidence in depression associated with traumatic brain injury (TBI). Here, we investigate the use of rTMS targeted with individualized resting-state network mapping (RSNM) of dorsal attention...