Synthesis and biological evaluation of simplified mycothiazole analogues
New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L 4 larvae of Nippostrongylus brasiliensis. Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HC...
Saved in:
Published in | Bioorganic & medicinal chemistry letters Vol. 16; no. 5; pp. 1309 - 1311 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.03.2006
Elsevier |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L
4 larvae of
Nippostrongylus brasiliensis.
Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L
4 larvae of nematode
Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity. |
---|---|
AbstractList | Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L(4) larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity. Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L sub(4) larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity. New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L 4 larvae of Nippostrongylus brasiliensis. Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L 4 larvae of nematode Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity. |
Author | Saldaña, Jenny Manta, Eduardo Mahler, Graciela Domínguez, Laura Dematteis, Sylvia Serra, Gloria |
Author_xml | – sequence: 1 givenname: Graciela surname: Mahler fullname: Mahler, Graciela organization: Departamento de Química Orgánica, Cátedra de Química Farmacéutica Facultad de Química, Universidad de la República, Montevideo, Uruguay – sequence: 2 givenname: Gloria surname: Serra fullname: Serra, Gloria organization: Departamento de Química Orgánica, Cátedra de Química Farmacéutica Facultad de Química, Universidad de la República, Montevideo, Uruguay – sequence: 3 givenname: Sylvia surname: Dematteis fullname: Dematteis, Sylvia organization: Cátedra de Inmunología, Universidad de la República, Montevideo, Uruguay – sequence: 4 givenname: Jenny surname: Saldaña fullname: Saldaña, Jenny organization: Cátedra de Farmacología, Facultad de Química, Universidad de la República, Montevideo, Uruguay – sequence: 5 givenname: Laura surname: Domínguez fullname: Domínguez, Laura organization: Cátedra de Farmacología, Facultad de Química, Universidad de la República, Montevideo, Uruguay – sequence: 6 givenname: Eduardo surname: Manta fullname: Manta, Eduardo email: emanta@fq.edu.uy organization: Departamento de Química Orgánica, Cátedra de Química Farmacéutica Facultad de Química, Universidad de la República, Montevideo, Uruguay |
BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17557279$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/16384701$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kMFq3DAQQEXZ0t2k_YEcgi_pze6MLVk29BJCmw0s5JAWehOyNG60yNbW8gY2X18tu5BbTnN5b2Z4F2wxhpEYu0IoELD-ti26wfiiBBAFYgGy_MBWyGueVxzEgq2grSFvWv5nyS5i3AIgB84_sSXWVcMl4Iqtnw7j_EzRxUyPNutc8OGvM9pn9KL9Xs8ujFnos-iGnXe9I5sNBxPmZ6dfg6ck6STsKX5mH3vtI305z0v2--ePX3frfPN4_3B3u8kNRzHnjUUgY7uGUFtrG8FJWoLO9pI3oibRc9FVrdV1JaA22JChspNV30pRllVZXbKvp727KfxLd2c1uGjIez1S2EeFEmTdNlUCyxNophDjRL3aTW7Q00EhqGM_tVXHfurYTyGq1C9J1-ft-24g-6acgyXg5gzomCr1kx6Ni2-cFEKWsk3c9xNHqcWLo0lF42g0ZN1EZlY2uPf--A-Aq5FP |
CitedBy_id | crossref_primary_10_1016_j_bmcl_2015_10_042 crossref_primary_10_1080_17415993_2014_975131 crossref_primary_10_1002_slct_201901633 crossref_primary_10_1016_j_ica_2015_07_022 crossref_primary_10_1039_b718045b crossref_primary_10_1016_j_arabjc_2014_11_034 crossref_primary_10_1517_17460441_2_S1_S25 crossref_primary_10_1021_np800817y crossref_primary_10_4236_ns_2011_33026 crossref_primary_10_1016_j_tetlet_2007_01_034 crossref_primary_10_3109_14756360903555258 crossref_primary_10_1002_jhet_2571 crossref_primary_10_1248_cpb_55_1126 crossref_primary_10_1007_s10593_011_0823_z crossref_primary_10_1021_np200673b crossref_primary_10_1016_j_bioorg_2019_103404 crossref_primary_10_1016_j_bmc_2010_06_072 crossref_primary_10_1002_ejoc_200600671 crossref_primary_10_1016_j_tet_2006_07_010 crossref_primary_10_1016_j_tet_2010_05_040 crossref_primary_10_1016_j_tetasy_2010_03_036 crossref_primary_10_2478_v10007_009_0033_8 crossref_primary_10_1021_acsmedchemlett_9b00302 crossref_primary_10_3390_md10040900 |
Cites_doi | 10.1021/ja00466a066 10.1002/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z 10.1021/ol047603q 10.1081/SCC-200057988 10.1021/ol000128l 10.1158/1535-7163.333.4.2 10.1016/S0040-4020(03)01020-2 10.1039/a605539g 10.1016/S0040-4039(01)01759-2 10.3987/COM-98-8244 10.1021/ja00221a042 10.1016/S0040-4039(00)81416-1 10.1021/jm0105171 10.1021/ol005777b |
ContentType | Journal Article |
Copyright | 2005 Elsevier Ltd 2006 INIST-CNRS |
Copyright_xml | – notice: 2005 Elsevier Ltd – notice: 2006 INIST-CNRS |
DBID | IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7QO 8FD FR3 P64 |
DOI | 10.1016/j.bmcl.2005.11.072 |
DatabaseName | Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef Biotechnology Research Abstracts Technology Research Database Engineering Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts |
DatabaseTitleList | MEDLINE Engineering Research Database |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Anatomy & Physiology Chemistry |
EISSN | 1464-3405 |
EndPage | 1311 |
ExternalDocumentID | 10_1016_j_bmcl_2005_11_072 16384701 17557279 S0960894X05014940 |
Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
GroupedDBID | --- --K --M .HR .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 53G 5GY 5VS 6TJ 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARLI AATCM AAXUO ABBQC ABFNM ABGSF ABJNI ABLVK ABMAC ABMZM ABTAH ABUDA ABXDB ABYKQ ABZDS ACDAQ ACGFS ACIUM ACNNM ACRLP ADBBV ADECG ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AFFNX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJSZI ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CS3 D0L DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FLBIZ FNPLU FYGXN G-2 G-Q GBLVA HEA HMK HMO HMS HMT HVGLF HZ~ IHE J1W KOM LCYCR LZ2 M29 M2Z M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCB SCC SDF SDG SDP SES SEW SOC SPC SPCBC SPT SSH SSK SSP SSU SSZ T5K WUQ XFK XPP Y6R YK3 ZMT ZY4 ~02 ~G- ABPIF ABPTK IQODW AAXKI AKRWK CGR CUY CVF ECM EIF NPM AAYXX AFJKZ CITATION 7QO 8FD FR3 P64 |
ID | FETCH-LOGICAL-c415t-8d10ecdb8e1addd854e7de0bdf74856e5f45b39da63506c18ece2b73f97522323 |
IEDL.DBID | AIKHN |
ISSN | 0960-894X |
IngestDate | Sun Sep 29 07:48:33 EDT 2024 Thu Sep 26 16:09:20 EDT 2024 Sat Sep 28 07:52:45 EDT 2024 Sun Oct 22 16:05:15 EDT 2023 Fri Feb 23 02:23:04 EST 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 5 |
Keywords | Anthelmintic HTC-15 colon cells Mycothiazole Deoxo-Fluor Thiazolines Oxazolines Antineoplastic agent Five membered ring Thiazole derivatives Cytotoxicity Organic carbamate Nippostrongylus brasiliensis Structure activity relation Colon Secondary alcohol Chemical synthesis Nematoda Oxazole derivatives Tumor cell Oxygen nitrogen heterocycle Human Sulfur nitrogen heterocycle Aliphatic compound In vitro Cell line Larva Helmintha Parasiticide Nemathelminthia Invertebrata Ethylenic compound |
Language | English |
License | CC BY 4.0 |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c415t-8d10ecdb8e1addd854e7de0bdf74856e5f45b39da63506c18ece2b73f97522323 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 16384701 |
PQID | 17076983 |
PQPubID | 23462 |
PageCount | 3 |
ParticipantIDs | proquest_miscellaneous_17076983 crossref_primary_10_1016_j_bmcl_2005_11_072 pubmed_primary_16384701 pascalfrancis_primary_17557279 elsevier_sciencedirect_doi_10_1016_j_bmcl_2005_11_072 |
PublicationCentury | 2000 |
PublicationDate | 2006-03-01 |
PublicationDateYYYYMMDD | 2006-03-01 |
PublicationDate_xml | – month: 03 year: 2006 text: 2006-03-01 day: 01 |
PublicationDecade | 2000 |
PublicationPlace | Oxford |
PublicationPlace_xml | – name: Oxford – name: England |
PublicationTitle | Bioorganic & medicinal chemistry letters |
PublicationTitleAlternate | Bioorg Med Chem Lett |
PublicationYear | 2006 |
Publisher | Elsevier Ltd Elsevier |
Publisher_xml | – name: Elsevier Ltd – name: Elsevier |
References | Wipf, Reeves, Balachadran, Day (bib6) 2002; 45 Yamaguchi, Hirao (bib7) 1983; 24 Skehan, P. V. Cytotoxicity and Cell Growth Assays, in Cell Biology. bib11 . / Simmons, Andrianasolo, McPhail, Flatt, Gerwick (bib4) 2005; 4 Crews, Kakou, Quiñoà, Cutignano, Bruno, Bifulco, Casapullo, Debitus, Gómez-Paloma, Riccio (bib1) 1988; 110 Argabrigth, Rider, Sieck (bib8) 1965; 50 NCI-USA results can be consulted on Internet Phillips, Wipf, Uto, Williams (bib10) 2000; 2 Sugiyama, Yokokawa, Shioiri, Sugiyama, Yokokawa, Shioiri, Le Flohic, Meyer, Cossy (bib3) 2000; 2 Mahler, Serra, Manta, Mahler, Serra, Antonow, Manta, Serra, Mahler, Manta (bib5) 2005; 35 Aitken, Armstrong, Galt, Mesher (bib9) 1997 Gordon, Costa, Incerti, Manta, Saldaña, Domínguez, Mariezcurrena, Suescum (bib14) 1997; 52 2nd ed., 1998, Vol. I. Minster, Jordis, Evans, Hecht (bib12) 1977; 99 Crews (10.1016/j.bmcl.2005.11.072_bib1a) 1988; 110 Minster (10.1016/j.bmcl.2005.11.072_bib12) 1977; 99 Yamaguchi (10.1016/j.bmcl.2005.11.072_bib7) 1983; 24 Cutignano (10.1016/j.bmcl.2005.11.072_bib1b) 2001; 66 Mahler (10.1016/j.bmcl.2005.11.072_bib5_2) 2001; 42 Gordon (10.1016/j.bmcl.2005.11.072_bib14) 1997; 52 Serra (10.1016/j.bmcl.2005.11.072_bib5_3) 1998; 48 Simmons (10.1016/j.bmcl.2005.11.072_bib4) 2005; 4 Mahler (10.1016/j.bmcl.2005.11.072_bib5a) 2005; 35 Wipf (10.1016/j.bmcl.2005.11.072_bib6) 2002; 45 10.1016/j.bmcl.2005.11.072_bib13 Le Flohic (10.1016/j.bmcl.2005.11.072_bib3c) 2005; 7 Sugiyama (10.1016/j.bmcl.2005.11.072_bib3b) 2003; 59 Sugiyama (10.1016/j.bmcl.2005.11.072_bib3a) 2000; 2 10.1016/j.bmcl.2005.11.072_bib2 Argabrigth (10.1016/j.bmcl.2005.11.072_bib8) 1965; 50 Aitken (10.1016/j.bmcl.2005.11.072_bib9) 1997 Phillips (10.1016/j.bmcl.2005.11.072_bib10) 2000; 2 |
References_xml | – volume: 24 start-page: 391 year: 1983 ident: bib7 publication-title: Tetrahedron Lett. contributor: fullname: Hirao – volume: 2 start-page: 2149 year: 2000 ident: bib3 publication-title: Org. Lett. contributor: fullname: Cossy – ident: bib11 – volume: 45 start-page: 1901 year: 2002 ident: bib6 publication-title: J. Med. Chem. contributor: fullname: Day – volume: 2 start-page: 1165 year: 2000 ident: bib10 publication-title: Org. Lett. contributor: fullname: Williams – volume: 35 start-page: 1481 year: 2005 ident: bib5 publication-title: Synth. Commun. contributor: fullname: Manta – volume: 52 start-page: 603 year: 1997 ident: bib14 publication-title: Il Farmaco contributor: fullname: Suescum – start-page: 935 year: 1997 ident: bib9 publication-title: J. Chem. Soc., Perkin Trans. 1 contributor: fullname: Mesher – volume: 4 start-page: 333 year: 2005 ident: bib4 publication-title: Mol. Cancer Ther. contributor: fullname: Gerwick – volume: 110 start-page: 4365 year: 1988 ident: bib1 publication-title: J. Am. Chem. Soc. contributor: fullname: Riccio – volume: 50 start-page: 3317 year: 1965 ident: bib8 publication-title: J. Org. Chem. contributor: fullname: Sieck – volume: 99 start-page: 8078 year: 1977 ident: bib12 publication-title: J. Am. Chem. Soc. contributor: fullname: Hecht – volume: 99 start-page: 8078 year: 1977 ident: 10.1016/j.bmcl.2005.11.072_bib12 publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00466a066 contributor: fullname: Minster – volume: 66 start-page: 775 year: 2001 ident: 10.1016/j.bmcl.2005.11.072_bib1b publication-title: Eur. J. Org. Chem. doi: 10.1002/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z contributor: fullname: Cutignano – ident: 10.1016/j.bmcl.2005.11.072_bib2 – volume: 7 start-page: 339 year: 2005 ident: 10.1016/j.bmcl.2005.11.072_bib3c publication-title: Org. Lett. doi: 10.1021/ol047603q contributor: fullname: Le Flohic – volume: 35 start-page: 1481 year: 2005 ident: 10.1016/j.bmcl.2005.11.072_bib5a publication-title: Synth. Commun. doi: 10.1081/SCC-200057988 contributor: fullname: Mahler – volume: 2 start-page: 2149 year: 2000 ident: 10.1016/j.bmcl.2005.11.072_bib3a publication-title: Org. Lett. doi: 10.1021/ol000128l contributor: fullname: Sugiyama – volume: 4 start-page: 333 year: 2005 ident: 10.1016/j.bmcl.2005.11.072_bib4 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.333.4.2 contributor: fullname: Simmons – volume: 59 start-page: 6579 year: 2003 ident: 10.1016/j.bmcl.2005.11.072_bib3b publication-title: Tetrahedron doi: 10.1016/S0040-4020(03)01020-2 contributor: fullname: Sugiyama – start-page: 935 year: 1997 ident: 10.1016/j.bmcl.2005.11.072_bib9 publication-title: J. Chem. Soc., Perkin Trans. 1 doi: 10.1039/a605539g contributor: fullname: Aitken – volume: 42 start-page: 8143 year: 2001 ident: 10.1016/j.bmcl.2005.11.072_bib5_2 publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(01)01759-2 contributor: fullname: Mahler – volume: 48 start-page: 2035 year: 1998 ident: 10.1016/j.bmcl.2005.11.072_bib5_3 publication-title: Heterocycles doi: 10.3987/COM-98-8244 contributor: fullname: Serra – volume: 110 start-page: 4365 year: 1988 ident: 10.1016/j.bmcl.2005.11.072_bib1a publication-title: J. Am. Chem. Soc. doi: 10.1021/ja00221a042 contributor: fullname: Crews – volume: 24 start-page: 391 year: 1983 ident: 10.1016/j.bmcl.2005.11.072_bib7 publication-title: Tetrahedron Lett. doi: 10.1016/S0040-4039(00)81416-1 contributor: fullname: Yamaguchi – volume: 50 start-page: 3317 year: 1965 ident: 10.1016/j.bmcl.2005.11.072_bib8 publication-title: J. Org. Chem. contributor: fullname: Argabrigth – volume: 45 start-page: 1901 year: 2002 ident: 10.1016/j.bmcl.2005.11.072_bib6 publication-title: J. Med. Chem. doi: 10.1021/jm0105171 contributor: fullname: Wipf – ident: 10.1016/j.bmcl.2005.11.072_bib13 – volume: 52 start-page: 603 year: 1997 ident: 10.1016/j.bmcl.2005.11.072_bib14 publication-title: Il Farmaco contributor: fullname: Gordon – volume: 2 start-page: 1165 year: 2000 ident: 10.1016/j.bmcl.2005.11.072_bib10 publication-title: Org. Lett. doi: 10.1021/ol005777b contributor: fullname: Phillips |
SSID | ssj0014044 |
Score | 1.9776175 |
Snippet | New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L
4 larvae of
Nippostrongylus brasiliensis.... Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon... |
SourceID | proquest crossref pubmed pascalfrancis elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1309 |
SubjectTerms | Animals Anthelmintic Anthelmintics - chemical synthesis Anthelmintics - chemistry Anthelmintics - pharmacology Anthelmintics - toxicity Antibiotics. Antiinfectious agents. Antiparasitic agents Antineoplastic agents Antiparasitic agents Biological and medical sciences Cell Line, Tumor Deoxo-Fluor General aspects HTC-15 colon cells Larva - drug effects Medical sciences Molecular Structure Mycothiazole Nematoda Nippostrongylus - drug effects Nippostrongylus brasiliensis Oxazolines Oxazolone - analogs & derivatives Oxazolone - chemical synthesis Oxazolone - chemistry Pharmacology. Drug treatments Structure-Activity Relationship Thiazoles - chemical synthesis Thiazoles - chemistry Thiazoles - pharmacology Thiazoles - toxicity Thiazolines |
Title | Synthesis and biological evaluation of simplified mycothiazole analogues |
URI | https://dx.doi.org/10.1016/j.bmcl.2005.11.072 https://www.ncbi.nlm.nih.gov/pubmed/16384701 https://search.proquest.com/docview/17076983 |
Volume | 16 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6VVIJKCEEKbQqEPSAuyMQb7_MYRVQB1F5Kpdws78OSUeNEdXoIB347s167UQ_lwNXakVczq5lv3gAfjaO00MolaKtMEhJvSZgBnUir3bTIhNIuNApfXIrFNfu-5MsDmPe9MKGsstP9Uae32rr7Mum4OdlU1eQqgG-l2TINqTHN0G8_RHPE2AAOZ99-LC7vkwksbXe6hvNJIOh6Z2KZl1nZmxhaCcM85fQx-_R8UzTItTKuu3gcj7Z26fwlvOgAJZnFO7-CA18P4XhWozO92pFPpC3xbGPnQ3g279e7DeHpRZdVP4bF1a5GHNhUDSlqR-JcpiA8sp8FTtYlaapQfl4iaCWrnUURV8Xv9Y1HohgBal7D9fnXn_NF0m1YSCwa7m2iHE29dUZ5inrOKc68dD41rpRMceF5ybjJtCsQlqTCUuWtnxqZlVoibsum2RsY1OvanwIR6MjgIaZRXzLqSmMFt0aG8WtGlIKO4HPP13wTB2nkfYXZrzxIIWzE5OiR5EgzAt6zPn_wHHLU9P-kGz-Q0_5XknOEanoEH3rB5cjwkB0par--a_BEKoVW2QhOojz3tKijmEzp2X9e6i0cxcBNqFx7B4Pt7Z1_j1Bma8bw5MsfOu4e7F8dy_Li |
link.rule.ids | 315,786,790,4521,24144,27955,27956,45618,45712 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9tAEB5CCk2hlNbpw22T7KH0UlRL1j6PwSQ4bZxLEvBNaLUrUIhlUzkH55Df3hmtVJNDeshVzKBlZpn55rEzAN-sS5LcaBehr7IRFd4imgEdqcK4cZ5KbRw9FJ5dyOk1_zUX8x2Y9G9hqK2ys_3BprfWuvsy6qQ5WlXV6JLAtzZ8HlNpzHCM218QGqC-rp8P__o8aHxMO0MKqSMi717OhCYvuyhuQ2KFRnmq8VPe6fUqb1BmZVh28TQabb3S6Vt408FJdhxO_A52fD2A_eMaQ-nFhn1nbYNnmzkfwN6kX-42gJezrqa-D9PLTY0osKkalteOhalMpDq2nQTOliVrKmo-LxGyssWmQAVX-f3y1iNTyP807-H69ORqMo26_QpRgW57HWmXxL5wVvsErZzTgnvlfGxdqbgW0ouSC5salyMoiWWRaF_4sVVpaRSitnScfoDdeln7T8AkhjFIxA1aS5640hZSFFbR8DUrS5kM4Ucv12wVxmhkfX_ZTUZaoH2YAuORDHmGIHrRZ48uQ4Z2_r98h4_0tP2VEgKBmhnCUa-4DAVOtZG89su7BiliJY1Oh_Ax6HPLixaKqzj5_MxDHcHe9Gp2np2fXfz-Aq9CCod62L7C7vrPnT9AULO2h-2l_QtGOPO3 |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+biological+evaluation+of+simplified+mycothiazole+analogues&rft.jtitle=Bioorganic+%26+medicinal+chemistry+letters&rft.au=Mahler%2C+Graciela&rft.au=Serra%2C+Gloria&rft.au=Dematteis%2C+Sylvia&rft.au=Salda%C3%B1a%2C+Jenny&rft.date=2006-03-01&rft.issn=0960-894X&rft.volume=16&rft.issue=5&rft.spage=1309&rft_id=info:doi/10.1016%2Fj.bmcl.2005.11.072&rft_id=info%3Apmid%2F16384701&rft.externalDocID=16384701 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0960-894X&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0960-894X&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0960-894X&client=summon |