Synthesis and biological evaluation of simplified mycothiazole analogues
New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L 4 larvae of Nippostrongylus brasiliensis. Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HC...
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Published in | Bioorganic & medicinal chemistry letters Vol. 16; no. 5; pp. 1309 - 1311 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.03.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | New structurally mycothiazole analogues were synthesized and evaluated against HCT-15 colon tumor cells and L
4 larvae of
Nippostrongylus brasiliensis.
Thiazoline and oxazoline analogues of the natural product mycothiazole were synthesized from a common intermediate and evaluated in vitro against HCT-15 colon cancer cells and L
4 larvae of nematode
Nippostrongylus brasiliensis. The nature of the heterocyclic moiety seems to modulate the cytotoxic or anthelmintic activity. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0960-894X 1464-3405 |
DOI: | 10.1016/j.bmcl.2005.11.072 |