Antioxidant and antiapoptotic activities of idoxifene and estradiol in hepatic fibrosis in rats

• Published in: Life sciences (1973) Vol. 74; no. 7; pp. 897 - 907
• Main Authors: Lu, Guangming, Shimizu, Ichiro, Cui, Xuezhi, Itonaga, Mina, Tamaki, Katsuyoshi, Fukuno, Hiroshi, Inoue, Hiroshi, Honda, Hirohito, Ito, Susumu
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 02.01.2004
• Subjects: Administration, Oral; Animals; Antioxidants - therapeutic use; Apoptosis; Apoptosis - drug effects; Bcl-2; bcl-Associated Death Protein; bcl-X Protein; Carrier Proteins - metabolism; Dimethylnitrosamine - toxicity; Disease Models, Animal; Drug Therapy, Combination; Estradiol; Estradiol - administration & dosage; Estradiol - therapeutic use; Estrogen Antagonists - therapeutic use; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; Glutathione peroxidase; Glutathione Peroxidase - metabolism; Idoxifene; Injections, Intraperitoneal; L-Lactate Dehydrogenase - blood; Liver - drug effects; Liver - metabolism; Liver - pathology; Liver Cirrhosis, Experimental - blood; Liver Cirrhosis, Experimental - drug therapy; Liver Cirrhosis, Experimental - pathology; Male; Malondialdehyde - blood; Oxidative stress; Proto-Oncogene Proteins c-bcl-2 - metabolism; Rats; Rats, Wistar; Superoxide dismutase; Superoxide Dismutase - metabolism; Tamoxifen - administration & dosage; Tamoxifen - analogs & derivatives; Tamoxifen - therapeutic use; Glutathione peroxidase; Bcl-2; Oxidative stress; Idoxifene; Superoxide dismutase; Estradiol; Apoptosis

Oxidative stress plays a causative role in the development of hepatic fibrosis and apoptosis. Estradiol (E2) is an antioxidant, and idoxifene is a tissue-specific selective estrogen receptor modulator. We have previously demonstrated that E2 inhibits hepatic fibrosis in a rat model of hepatic fibros...