Chronic orthostatic intolerance: a disorder with discordant cardiac and vascular sympathetic control

• Published in: Circulation (New York, N.Y.) Vol. 98; no. 20; pp. 2154 - 2159
• Main Authors: Furlan, R., Jacob, G., Snell, M., Robertson, D., Porta, A., Harris, P., Mosqueda-Garcia, R.
• Format: Journal Article
• Language: English
• Published: Legacy CDMS Lippincott Williams & Wilkins 17.11.1998; American Heart Association, Inc
• Subjects: Adult; Biological and medical sciences; Chronic Disease; Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction; Female; Hemodynamics; Humans; Life Sciences (General); Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; Posture; Pressoreceptors - physiology; Reflex; Sympathetic Nervous System - physiology; Tachycardia - physiopathology; Human; Reflex; Non-Nasa Center; Tachycardia/physiopathology; Male; Pressoreceptors/physiology; Posture; Sympathetic Nervous System/physiology; Nasa Discipline Regulatory Physiology; Adult; Female; Hemodynamic Processes; Chronic Disease; Nervous system diseases; Pathogenesis; Autonomic nervous system; Consciousness impairment; Diseases of the autonomic nervous system; Arterial pressure; Baroreceptor; Hemodynamics; Neurological disorder; Vasovagal syncope; NASA Discipline Regulatory Physiology; Non-NASA Center

BACKGROUND: Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function and of baroreflex control of heart rate (HR). METHODS AND RESULTS: In 16 COI patients and 1...