The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury
Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actio...
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Published in | Molecular neurobiology Vol. 55; no. 11; pp. 8651 - 8667 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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01.11.2018
Springer Nature B.V |
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Abstract | Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice. By 7 days after brain injury, tibolone reduced the number of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes, the number of ionized calcium binding adaptor molecule 1 (Iba1) immunoreactive microglia, and the number of microglial cells with a reactive phenotype in comparison to vehicle-injected animals. These effects on gliosis were associated with a reduction in neuronal loss in the proximity to the wound, suggesting that tibolone exerts beneficial homeostatic actions in the cerebral cortex after an acute brain injury. |
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AbstractList | Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice. By 7 days after brain injury, tibolone reduced the number of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes, the number of ionized calcium binding adaptor molecule 1 (Iba1) immunoreactive microglia, and the number of microglial cells with a reactive phenotype in comparison to vehicle-injected animals. These effects on gliosis were associated with a reduction in neuronal loss in the proximity to the wound, suggesting that tibolone exerts beneficial homeostatic actions in the cerebral cortex after an acute brain injury. Previous studies have shown that estradiol reduces reactive gliosis after a stab wound injury in the cerebral cortex. Since the therapeutic use of estradiol is limited by its peripheral hormonal effects, it is of interest to determine whether synthetic estrogenic compounds with tissue-specific actions regulate reactive gliosis. Tibolone is a synthetic steroid that is widely used for the treatment of climacteric symptoms and/or the prevention of osteoporosis. In this study, we have assessed the effect of tibolone on reactive gliosis in the cerebral cortex after a stab wound brain injury in ovariectomized adult female mice. By 7 days after brain injury, tibolone reduced the number of glial fibrillary acidic protein (GFAP) immunoreactive astrocytes, the number of ionized calcium binding adaptor molecule 1 (Iba1) immunoreactive microglia, and the number of microglial cells with a reactive phenotype in comparison to vehicle-injected animals. These effects on gliosis were associated with a reduction in neuronal loss in the proximity to the wound, suggesting that tibolone exerts beneficial homeostatic actions in the cerebral cortex after an acute brain injury. |
Author | Crespo-Castrillo, Andrea Barreto, George E. Arevalo, Maria Angeles Garcia-Segura, Luis M. Yanguas-Casás, Natalia Azcoitia, Iñigo |
Author_xml | – sequence: 1 givenname: Andrea surname: Crespo-Castrillo fullname: Crespo-Castrillo, Andrea organization: Consejo Superior de Investigaciones Científicas (CSIC), Instituto Cajal – sequence: 2 givenname: Natalia surname: Yanguas-Casás fullname: Yanguas-Casás, Natalia organization: Consejo Superior de Investigaciones Científicas (CSIC), Instituto Cajal, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III – sequence: 3 givenname: Maria Angeles surname: Arevalo fullname: Arevalo, Maria Angeles organization: Consejo Superior de Investigaciones Científicas (CSIC), Instituto Cajal, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III – sequence: 4 givenname: Iñigo surname: Azcoitia fullname: Azcoitia, Iñigo organization: Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Department of Cell Biology, Faculty of Biology, Universidad Complutense – sequence: 5 givenname: George E. surname: Barreto fullname: Barreto, George E. email: gsampaio@javeriana.edu.co organization: Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana – sequence: 6 givenname: Luis M. orcidid: 0000-0002-2450-2916 surname: Garcia-Segura fullname: Garcia-Segura, Luis M. email: lmgs@cajal.csic.es organization: Consejo Superior de Investigaciones Científicas (CSIC), Instituto Cajal, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29582398$$D View this record in MEDLINE/PubMed |
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Title | The Synthetic Steroid Tibolone Decreases Reactive Gliosis and Neuronal Death in the Cerebral Cortex of Female Mice After a Stab Wound Injury |
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