Physiological and pathological role of local and immigrating colonic stem cells

The latest avenue of research is revealing the existence of and role for the colonic stem cells in the physiological renewal of the mucosa and in pathological circumstanc- es where they have both positive and negative effects. In the case of human colon, different levels of stem cell compartments ex...

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Published inWorld journal of gastroenterology : WJG Vol. 18; no. 4; pp. 295 - 301
Main Authors Sipos, Ferenc, Valcz, Gábor, Molnár, Béla
Format Journal Article
LanguageEnglish
Published United States Baishideng Publishing Group Co., Limited 28.01.2012
Subjects
Cell Movement - physiology
Cell Transformation, Neoplastic - pathology
Colon - cytology
Colon - pathology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - physiopathology
Disease Progression
Epithelial Cells - cytology
Epithelial Cells - pathology
Epithelial Cells - physiology
Humans
Intestinal Mucosa - cytology
Intestinal Mucosa - pathology
Intestinal Mucosa - physiology
Neoplasm Invasiveness
Stem Cells - cytology
Stem Cells - physiology
Wound Healing
上皮干细胞
干细胞生物学
慢性炎症
生理
病理作用
移民
细胞动力学
结肠癌
Parathyroid hormone
Myofibroblast
Transforming growth factor-β
Colorectal cancer
Fibrosis
Bone marrow
Colon
Mesencyhmal stem cells
Online AccessGet full text

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Abstract The latest avenue of research is revealing the existence of and role for the colonic stem cells in the physiological renewal of the mucosa and in pathological circumstanc- es where they have both positive and negative effects. In the case of human colon, different levels of stem cell compartments exist. First, the crypt epithelial stem cells, which have a role in the normal crypt epithelial cell dynamics and in colorectal carcinogenesis. Close to the crypts, the second layer of stern cells can be found; the local subepithelial stem cell niche, including the pericryptic subepithelial myofibroblasts that regulate the epithelial cell differentiation and have a crucial role in cancer progression and chronic inflammation-related fibrosis. The third level of stem cell compartment is the immigrating bone-marrow-derived stem cells, which have an important role in wound healing after severe mucosal inflammation, but are also involved in cancer invasion. This paper focuses on stem cell biology in the context of physiological and pathological processes in the human colon.
AbstractList The latest avenue of research is revealing the existence of and role for the colonic stem cells in the physiological renewal of the mucosa and in pathological circumstanc- es where they have both positive and negative effects. In the case of human colon, different levels of stem cell compartments exist. First, the crypt epithelial stem cells, which have a role in the normal crypt epithelial cell dynamics and in colorectal carcinogenesis. Close to the crypts, the second layer of stern cells can be found; the local subepithelial stem cell niche, including the pericryptic subepithelial myofibroblasts that regulate the epithelial cell differentiation and have a crucial role in cancer progression and chronic inflammation-related fibrosis. The third level of stem cell compartment is the immigrating bone-marrow-derived stem cells, which have an important role in wound healing after severe mucosal inflammation, but are also involved in cancer invasion. This paper focuses on stem cell biology in the context of physiological and pathological processes in the human colon.
The latest avenue of research is revealing the existence of and role for the colonic stem cells in the physiological renewal of the mucosa and in pathological circumstances where they have both positive and negative effects. In the case of human colon, different levels of stem cell compartments exist. First, the crypt epithelial stem cells, which have a role in the normal crypt epithelial cell dynamics and in colorectal carcinogenesis. Close to the crypts, the second layer of stem cells can be found; the local subepithelial stem cell niche, including the pericryptic subepithelial myofibroblasts that regulate the epithelial cell differentiation and have a crucial role in cancer progression and chronic inflammation-related fibrosis. The third level of stem cell compartment is the immigrating bone-marrow-derived stem cells, which have an important role in wound healing after severe mucosal inflammation, but are also involved in cancer invasion. This paper focuses on stem cell biology in the context of physiological and pathological processes in the human colon.
Author Ferenc Sipos Gabor Valcz Bela Molnar
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Issue 4
Keywords Parathyroid hormone
Myofibroblast
Transforming growth factor-β
Colorectal cancer
Fibrosis
Bone marrow
Colon
Mesencyhmal stem cells
Language English
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Notes 14-1219/R
Colon; Mesencyhmal stem cells; Bone marrow; Myofibroblast; Fibrosis; Colorectal cancer; Para-thyroid hormone; Transforming growth factor-β
The latest avenue of research is revealing the existence of and role for the colonic stem cells in the physiological renewal of the mucosa and in pathological circumstanc- es where they have both positive and negative effects. In the case of human colon, different levels of stem cell compartments exist. First, the crypt epithelial stem cells, which have a role in the normal crypt epithelial cell dynamics and in colorectal carcinogenesis. Close to the crypts, the second layer of stern cells can be found; the local subepithelial stem cell niche, including the pericryptic subepithelial myofibroblasts that regulate the epithelial cell differentiation and have a crucial role in cancer progression and chronic inflammation-related fibrosis. The third level of stem cell compartment is the immigrating bone-marrow-derived stem cells, which have an important role in wound healing after severe mucosal inflammation, but are also involved in cancer invasion. This paper focuses on stem cell biology in the context of physiological and pathological processes in the human colon.
Correspondence to: Ferenc Sipos, MD, PhD, 2nd Department of Internal Medicine, Semmelweis University, 1088 Budapest, Hungary. dr.siposf@gmail.com
Author contributions: Sipos F and Valcz G contributed to the writing and revising of this paper; Molnár B revised and edited the manuscript.
Telephone: +36-20-4780752 Fax: +36-1-2660816
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SubjectTerms Cell Movement - physiology
Cell Transformation, Neoplastic - pathology
Colon - cytology
Colon - pathology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - physiopathology
Disease Progression
Epithelial Cells - cytology
Epithelial Cells - pathology
Epithelial Cells - physiology
Humans
Intestinal Mucosa - cytology
Intestinal Mucosa - pathology
Intestinal Mucosa - physiology
Neoplasm Invasiveness
Stem Cells - cytology
Stem Cells - physiology
Wound Healing
上皮干细胞
干细胞生物学
慢性炎症
生理
病理作用
移民
细胞动力学
结肠癌
Title Physiological and pathological role of local and immigrating colonic stem cells
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