Efficacy of a Spatial Repellent for Control of Malaria in Indonesia: A Cluster-Randomized Controlled Trial
A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given...
Saved in:
| Published in | The American journal of tropical medicine and hygiene Vol. 103; no. 1; pp. 344 - 358 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Institute of Tropical Medicine
01.07.2020
The American Society of Tropical Medicine and Hygiene |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015-March 2016) and a 24-month intervention period (April 2016-April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% (
-value = 0.083) and 40.9% (
-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission. |
|---|---|
| AbstractList | A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015-March 2016) and a 24-month intervention period (April 2016-April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% (
-value = 0.083) and 40.9% (
-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission. A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015–March 2016) and a 24-month intervention period (April 2016–April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% (P-value = 0.083) and 40.9% (P-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission. A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015–March 2016) and a 24-month intervention period (April 2016–April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% ( P -value = 0.083) and 40.9% ( P -value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission. A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015-March 2016) and a 24-month intervention period (April 2016-April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% (P-value = 0.083) and 40.9% (P-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission.A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against malaria infection in Sumba, Indonesia. Following radical cure in 1,341 children aged ≥ 6 months to ≤ 5 years in 24 clusters, households were given transfluthrin or placebo passive emanators (devices designed to release vaporized chemical). Monthly blood screening and biweekly human-landing mosquito catches were performed during a 10-month baseline (June 2015-March 2016) and a 24-month intervention period (April 2016-April 2018). Screening detected 164 first-time infections and an accumulative total of 459 infections in 667 subjects in placebo-control households, and 134 first-time and 253 accumulative total infections among 665 subjects in active intervention households. The 24-cluster protective effect of 27.7% and 31.3%, for time to first-event and overall (total new) infections, respectively, was not statistically significant. Purportedly, this was due in part to zero to low incidence in some clusters, undermining the ability to detect a protective effect. Subgroup analysis of 19 clusters where at least one infection occurred during baseline showed 33.3% (P-value = 0.083) and 40.9% (P-value = 0.0236, statistically significant at the one-sided 5% significance level) protective effect to first infection and overall infections, respectively. Among 12 moderate- to high-risk clusters, a statistically significant decrease in infection by intervention was detected (60% PE). Primary entomological analysis of impact was inconclusive. Although this study suggests SRs prevent malaria, additional evidence is required to demonstrate the product class provides an operationally feasible and effective means of reducing malaria transmission. |
| Author | Permana, Dendi Hadi Achee, Nicole L. Zubaidah, Siti Bøgh, Claus Collins, Frank Syahrani, Lepa Grieco, John P. Rozi, Ismail Ekoprayitno Eugenio, Evercita C. Baird, J. Kevin Hendrickson, Jared Burton, Timothy Bangs, Michael J. Lobo, Neil F. Sidik, Dian Asih, Puji B. S. Nur Hidayati, Anggi Puspa Liu, Fang Syafruddin, Din |
| Author_xml | – sequence: 1 givenname: Din surname: Syafruddin fullname: Syafruddin, Din organization: Department of Parasitology, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia;, Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 2 givenname: Puji B. S. surname: Asih fullname: Asih, Puji B. S. organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 3 givenname: Ismail Ekoprayitno surname: Rozi fullname: Rozi, Ismail Ekoprayitno organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 4 givenname: Dendi Hadi surname: Permana fullname: Permana, Dendi Hadi organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 5 givenname: Anggi Puspa surname: Nur Hidayati fullname: Nur Hidayati, Anggi Puspa organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 6 givenname: Lepa surname: Syahrani fullname: Syahrani, Lepa organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 7 givenname: Siti surname: Zubaidah fullname: Zubaidah, Siti organization: Eijkman Institute for Molecular Biology, Jakarta, Indonesia – sequence: 8 givenname: Dian surname: Sidik fullname: Sidik, Dian organization: Department of Epidemiology, Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia – sequence: 9 givenname: Michael J. surname: Bangs fullname: Bangs, Michael J. organization: Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Kuala Kencana, Papua, Indonesia – sequence: 10 givenname: Claus surname: Bøgh fullname: Bøgh, Claus organization: The Sumba Foundation, Public Health and Malaria Control, Bali, Indonesia – sequence: 11 givenname: Fang surname: Liu fullname: Liu, Fang organization: Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana – sequence: 12 givenname: Evercita C. surname: Eugenio fullname: Eugenio, Evercita C. organization: Department of Applied and Computational Mathematics and Statistics, University of Notre Dame, Notre Dame, Indiana – sequence: 13 givenname: Jared surname: Hendrickson fullname: Hendrickson, Jared organization: Center for Computer Research, University of Notre Dame, Notre Dame, Indiana – sequence: 14 givenname: Timothy surname: Burton fullname: Burton, Timothy organization: Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana – sequence: 15 givenname: J. Kevin surname: Baird fullname: Baird, J. Kevin organization: Nuffield Department of Medicine, Centre for Tropical Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia – sequence: 16 givenname: Frank surname: Collins fullname: Collins, Frank organization: Center for Computer Research, University of Notre Dame, Notre Dame, Indiana – sequence: 17 givenname: John P. surname: Grieco fullname: Grieco, John P. organization: Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana – sequence: 18 givenname: Neil F. surname: Lobo fullname: Lobo, Neil F. organization: Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana – sequence: 19 givenname: Nicole L. surname: Achee fullname: Achee, Nicole L. organization: Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, Indiana |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32431275$$D View this record in MEDLINE/PubMed |
| BookMark | eNptkc1rVDEUxYNU7LS6dCsBN25ezXfmuRDK0NZCRah1He7LJDZDXjIm7wn1rzfTdkSLq4Tkdw7n3nOEDlJODqHXlJwIpvr3sJnG2xPad0RK8QwtqNCqo0rIA7QghLCuV1wfoqNaN4TQJaP0BTrkTHDKtFygzZn3wYK9w9ljwF-3MAWI-NptXYwuTdjnglc5TSXHHfIZIpQAOCR8mdYtSg3wAZ_iVZzr5Ep3De11DL_ceq-K7XrTJPEleu4hVvfq8TxG387PblafuqsvF5er06vOCiqnTotlv-zX3A5qaYlUhOpBOe-U15ZqBVQxT0BoygWIRvhBK60UaSKv2UD4Mfr44Ludh9GtbZuiQDTbEkYodyZDMP_-pHBrvuefRnOpBFHN4N2jQck_ZlcnM4Zq2z4guTxXwwSRvHH36Nsn6CbPJbXxGsUEpYrKvlFv_k70J8q-hgbwB8CWXGtx3tgwtSZ2G4QQDSVmV7a5L9vQ3uzKbqruiWpv_H_-N38VrAo |
| CitedBy_id | crossref_primary_10_1186_s12936_024_05043_5 crossref_primary_10_1371_journal_pntd_0009036 crossref_primary_10_1186_s12936_021_03880_2 crossref_primary_10_1186_s12936_023_04685_1 crossref_primary_10_3390_tropicalmed7080178 crossref_primary_10_1186_s12936_023_04453_1 crossref_primary_10_1016_j_pt_2025_02_009 crossref_primary_10_3390_tropicalmed7110372 crossref_primary_10_1371_journal_pntd_0009672 crossref_primary_10_1371_journal_pone_0237353 crossref_primary_10_1186_s13063_024_08378_1 crossref_primary_10_1186_s13071_023_05685_5 crossref_primary_10_1073_pnas_2118283119 crossref_primary_10_1186_s12889_022_14301_7 crossref_primary_10_1016_S0140_6736_24_02754_5 crossref_primary_10_1186_s12936_020_03426_y crossref_primary_10_1186_s13071_024_06607_9 crossref_primary_10_1371_journal_pone_0276783 crossref_primary_10_1093_jme_tjaa213 crossref_primary_10_1038_s41598_023_38463_5 crossref_primary_10_1021_acsinfecdis_3c00294 crossref_primary_10_1186_s13063_022_06196_x crossref_primary_10_1186_s13063_022_06197_w crossref_primary_10_1016_j_crpvbd_2021_100070 crossref_primary_10_1186_s13071_022_05563_6 crossref_primary_10_1186_s13063_022_06998_z crossref_primary_10_3390_pathogens10091171 crossref_primary_10_1016_j_crpvbd_2022_100107 crossref_primary_10_1155_2022_4510182 crossref_primary_10_1371_journal_pone_0300368 crossref_primary_10_1186_s12936_023_04674_4 crossref_primary_10_1186_s12936_024_04841_1 crossref_primary_10_1371_journal_pntd_0010316 crossref_primary_10_2903_sp_efsa_2021_EN_6954 crossref_primary_10_1016_j_compbiomed_2023_107716 crossref_primary_10_1186_s13071_021_04754_x crossref_primary_10_1186_s12936_022_04375_4 crossref_primary_10_12688_wellcomeopenres_19131_3 crossref_primary_10_12688_wellcomeopenres_19131_2 crossref_primary_10_12688_wellcomeopenres_19131_1 crossref_primary_10_1016_j_actatropica_2025_107596 crossref_primary_10_1016_j_crpvbd_2024_100185 crossref_primary_10_1016_S0140_6736_24_02253_0 crossref_primary_10_1186_s12936_023_04568_5 crossref_primary_10_1186_s12936_024_04982_3 crossref_primary_10_1016_j_pestbp_2023_105387 crossref_primary_10_1186_s12936_022_04185_8 crossref_primary_10_1186_s12936_021_03972_z |
| Cites_doi | 10.1186/1475-2875-11-164 10.2987/08-5831.1 10.2987/8756-971X(2006)21[404:ANHSST]2.0.CO;2 10.1371/journal.pone.0110433 10.4269/ajtmh.13-0735 10.1201/b11505 10.1564/23dec13 10.1136/bmj.39489.470347.AD 10.4269/ajtmh.2007.76.641 10.1016/S0140-6736(07)60160-3 10.1186/s12936-015-0543-4 10.3390/ijerph14020124 10.1186/1756-3305-5-287 10.1017/S0007485300030091 10.1056/NEJMra1614394 10.1186/s12936-017-1881-1 10.1186/s12936-017-1918-5 10.1186/s12936-016-1234-5 10.1371/journal.pbio.1002380 10.1186/1475-2875-13-131 10.1146/annurev.ento.50.071803.130439 10.1097/EDE.0b013e3181c1ea43 10.1201/b16654 10.2307/270718 10.1016/j.pt.2015.04.015 10.4269/ajtmh.14-0194 10.1038/srep17952 10.1371/journal.pone.0000716 10.1093/jee/53.1.134 10.1186/s12936-016-1185-x 10.1038/200860a0 10.1146/annurev.publhealth.031308.100223 10.1186/1475-2875-10-222 10.1128/AAC.48.8.2787-2792.2004 10.1186/1472-6890-11-5 10.1201/9781420006650 10.1186/1475-2875-13-208 10.1603/029.102.0606 |
| ContentType | Journal Article |
| Copyright | Copyright Institute of Tropical Medicine Jul 2020 The American Society of Tropical Medicine and Hygiene 2020 |
| Copyright_xml | – notice: Copyright Institute of Tropical Medicine Jul 2020 – notice: The American Society of Tropical Medicine and Hygiene 2020 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.4269/ajtmh.19-0554 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1476-1645 |
| EndPage | 358 |
| ExternalDocumentID | PMC7356406 32431275 10_4269_ajtmh_19_0554 |
| Genre | Randomized Controlled Trial Journal Article |
| GeographicLocations | Indonesia |
| GeographicLocations_xml | – name: Indonesia |
| GroupedDBID | --- 23M 2WC 34G 36B 53G 5GY 5RE 5VS 6J9 AAYXX ABCQX ABPPZ ACGFO ADBBV ADTPD AENEX AIAGR ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL BTFSW CITATION DIK E3Z EBD EBS EJD EMB EMOBN F5P GX1 H13 HYE K-O KQ8 L7B MV1 OK1 P2P PQQKQ RHI RPM SV3 TR2 TST UPT W8F WH7 WOQ WOW ~KM .55 .GJ 1CY 3O- ABTNK AFFNX AGCDD AI. CGR CUY CVF ECM EIF NEJ NPM OHT PKN RHF VH1 X7M XOL ZGI ZKB ZXP 7X8 5PM |
| ID | FETCH-LOGICAL-c415t-748989d3cb68c056017b6efe6f7c176a162f0a47134a48c0fb767660989f72b03 |
| ISSN | 0002-9637 1476-1645 |
| IngestDate | Thu Aug 21 18:21:32 EDT 2025 Fri Jul 11 09:33:51 EDT 2025 Mon Jun 30 03:19:03 EDT 2025 Wed Feb 19 02:25:53 EST 2025 Thu Apr 24 23:00:21 EDT 2025 Tue Jul 01 03:04:11 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c415t-748989d3cb68c056017b6efe6f7c176a162f0a47134a48c0fb767660989f72b03 |
| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 content type line 14 ObjectType-Feature-3 ObjectType-Evidence Based Healthcare-1 ObjectType-Article-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 These authors contributed equally to this work. Financial support: This study was funded by a substantial award from the Bill and Melinda Gates Foundation to the University of Notre Dame (Grant #OPP1081737). We express our gratitude to the foundation for their long-term generosity and support of spatial repellent product evaluation and development, especially Kate Aultman, Dan Strickman, and Alan Magill. We are also deeply grateful to S.C. Johnson for its financial support. The company provided integral industry and product expertise, including the development, manufacturing, delivery and shipment of the interventions (active and placebo) used in the study. In addition, S.C. Johnson provided expertise in ensuring intervention quality, storage, application, and disposal assurances throughout the trial. Authors’ addresses: Din Syafruddin, Puji Asih, Ismail Ekoprayitno Rozi, Dendi Hadi Permana, Anggi Puspa Nur Hidayati, Lepa Syahrani, and Siti Zubaidah, Department of Malaria, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, E-mails: din@eijkman.go.id, puji@eijkman.go.id, eko@eijkman.go.id, dendi_hp@eijkman.go.id, anggie@eijkman.go.id, lepa@eijkman.go.id, and jeihan93@yahool.com. Dian Sidik, Department of Epidemiology, Faculty of Public Health, Universitas Hasanuddin, Makassar, Indonesia, E-mail: dian_sidiq@yahoo.com. Michael J. Bangs, Public Health and Malaria Control, PT Freeport Indonesia, International SOS, Kuala Kencana, Papua, Indonesia, E-mail: mbangs@fmi.com. Claus Bøgh, The Sumba Foundation, Public Health and Malaria Control, Bali, Indonesia, E-mail: cbogh@cbn.net.id. Fang Liu and Evercita C. Eugenio, Department of Applied Mathematics, University of Notre Dame, Notre Dame, IN, E-mails: fliu2@nd.edu and eeugenio@nd.edu. Jared Hendrickson, Center for Computer Research, University of Notre Dame, Notre Dame, IN, E-mail: jhendri4@nd.edu. Timothy Burton, Frank Collins, John P. Grieco, Neil F. Lobo, and Nicole L. Achee, Department of Biological Sciences, Eck Institute for Global Health, University of Notre Dame, Notre Dame, IN, E-mails: timothy.a.burton.39@nd.edu, frank@nd.edu, jgrieco@nd.edu, nlobo@nd.edu, and nachee@nd.edu. J. Kevin Baird, Eijkman-Oxford Clinical Research Unit, Oxford University, Jakarta, Indonesia, E-mail: jkevinbaird@yahoo.com. Disclaimer: The contents are the responsibility of the authors. |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7356406 |
| PMID | 32431275 |
| PQID | 2424116159 |
| PQPubID | 105381 |
| PageCount | 15 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7356406 proquest_miscellaneous_2405306306 proquest_journals_2424116159 pubmed_primary_32431275 crossref_citationtrail_10_4269_ajtmh_19_0554 crossref_primary_10_4269_ajtmh_19_0554 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-07-01 |
| PublicationDateYYYYMMDD | 2020-07-01 |
| PublicationDate_xml | – month: 07 year: 2020 text: 2020-07-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Deerfield, Illinois |
| PublicationTitle | The American journal of tropical medicine and hygiene |
| PublicationTitleAlternate | Am J Trop Med Hyg |
| PublicationYear | 2020 |
| Publisher | Institute of Tropical Medicine The American Society of Tropical Medicine and Hygiene |
| Publisher_xml | – name: Institute of Tropical Medicine – name: The American Society of Tropical Medicine and Hygiene |
| References | Achee (b9) 2009; 25 Guyatt (b64) 2008; 336 (b32) 2018 Ogoma (b11) 2014; 13 Collett (b58) 2002 Echeverry (b42) 2016; 15 Kennedy (b1) 1947; 37 Norris (b14) 2017; 14 Lengeler (b69) 1998; 2 Pates (b24) 2005; 50 Lobo (b46) 2015; 5 Hill (b18) 2014; 13 Miller (b5) 2009; 102 Redmond (b59) 2001 Monroe (b27) 2015; 14 Barbara (b36) 2011; 42 Debboun (b15) 2006 (b28) 2013 Hernán (b53) 2010; 21 Chow (b63) 2011 b68 Muirhead-Thomson (b2) 1951 (b13) 2018 Durnez (b25) 2013 Hemingway (b30) 2016; 14 Achee (b29) 2012; 11 Nkrumah (b39) 2011; 11 Lievens (b37) 2011; 10 Ogoma (b21) 2012; 5 St Laurent (b47) 2016; 15 (b41) 2018 b70 Ratcliff (b55) 2007; 369 (b16) 2017 Baird (b60) 2002; 72 (b61) 2018 Syafruddin (b19) 2014; 91 Grieco (b8) 2005; 21 Spruance (b52) 2004; 48 (b67) 2015 (b50) 2016 Achee (b22) 2012; 23 Alker (b54) 2007; 76 Dethier (b4) 1960; 53 (b33) 1998 (b20) 2017 (b34) 2010 Allison (b57) 1982; 13 (b40) 2016 (b7) 2013 Beier (b49) 2002; 72 Roberts (b6) 2000; 25 Grieco (b12) 2007; 2 Kalbfleisch (b56) 2011 De Zulueta (b3) 1963; 200 Harvey (b26) 2017; 16 Frieden (b65) 2017; 377 Detinova (b45) 1962; 47 Echeverry (b48) 2017; 16 Maia (b17) 2018; 2 (b23) 2017 (b51) 2010 Elyazar (b35) 2013 (b43) 2015 Wilson (b66) 2015; 31 Brown (b62) 2009; 30 O’Connors (b44) 1979 Ogoma (b10) 2014; 9 (b31) 2019 LaRue (b38) 2014; 91 33069263 - Am J Trop Med Hyg. 2020 Nov;103(5):2151 |
| References_xml | – volume: 11 start-page: 164 year: 2012 ident: b29 article-title: Spatial repellents: from discovery and development to evidence-based validation publication-title: Malar J doi: 10.1186/1475-2875-11-164 – volume-title: Biostatistics in Clinical Trials year: 2001 ident: b59 – start-page: 219 volume-title: Mosquito Behaviour in Relation to Malaria Transmission and Control in the Tropics year: 1951 ident: b2 – volume: 25 start-page: 156 year: 2009 ident: b9 article-title: Characterization of spatial repellent, contact irritant, and toxicant chemical actions of standard vector control compounds publication-title: J Am Mosq Control Assoc doi: 10.2987/08-5831.1 – volume-title: Guideline for Evaluating Insecticide Resistance in Vectors Using the CDC Bottle Bioassay year: 2010 ident: b51 – volume: 21 start-page: 404 year: 2005 ident: b8 article-title: A novel high-throughput screening system to evaluate the behavioral response of adult mosquitoes to chemicals publication-title: J Am Mosq Control Assoc doi: 10.2987/8756-971X(2006)21[404:ANHSST]2.0.CO;2 – volume: 9 start-page: e110433 year: 2014 ident: b10 article-title: The mode of action of spatial repellents and their impact on vectorial capacity of Anopheles gambiae sensu stricto publication-title: PLoS One doi: 10.1371/journal.pone.0110433 – volume: 91 start-page: 1079 year: 2014 ident: b19 article-title: Impact of a spatial repellent on malaria incidence in two villages in Sumba, Indonesia publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.13-0735 – volume-title: Test Procedures for Insecticide Resistance Monitoring in Malaria Vector Mosquitoes year: 2016 ident: b50 – start-page: 375 volume-title: Adaptive Design Methods in Clinical Trials year: 2011 ident: b63 doi: 10.1201/b11505 – volume: 42 start-page: 71 year: 2011 ident: b36 article-title: Survey of Anopheles mosquitoes (Diptera:Culicidae) in West Sumba district, Indonesia publication-title: Southeast Asian J Trop Med Public Health – volume: 23 start-page: 283 year: 2012 ident: b22 article-title: Is it time to formally recognize spatial repellency for disease prevention? publication-title: Outlooks Pest Management doi: 10.1564/23dec13 – volume: 336 start-page: 924 year: 2008 ident: b64 article-title: GRADE: an emerging consensus on rating quality of evidence and strength of recommendations publication-title: BMJ doi: 10.1136/bmj.39489.470347.AD – start-page: 1 volume-title: Guidelines for Malaria Vector Control year: 2019 ident: b31 – volume-title: Registration Decision for the New Active Ingredient, Transfluthrin year: 2018 ident: b41 – start-page: 1 volume-title: Kunci Kunci Bergambar Untuk Anopheles Betina Dari Indonesia year: 1979 ident: b44 – volume-title: World Malaria Report 2018 year: 2018 ident: b61 – volume: 76 start-page: 641 year: 2007 ident: b54 article-title: Pfmdr1 and in vivo resistance to artesunate-mefloquine in falciparum malaria on the Cambodian-Thai border publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.2007.76.641 – volume: 369 start-page: 757 year: 2007 ident: b55 article-title: Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison publication-title: Lancet doi: 10.1016/S0140-6736(07)60160-3 – volume: 14 start-page: 35 year: 2015 ident: b27 article-title: Outdoor-sleeping and other night-time activities in northern Ghana: implications for residual transmission and malaria prevention publication-title: Malar J doi: 10.1186/s12936-015-0543-4 – volume: 14 start-page: 124 year: 2017 ident: b14 article-title: Current and future repellent technologies: the potential of spatial repellents and their place in mosquito-borne disease control publication-title: Int J Environ Res Public Health doi: 10.3390/ijerph14020124 – volume: 5 start-page: 287 year: 2012 ident: b21 article-title: A systematic review of mosquito coils and passive emanators: defining recommendations for spatial repellency testing methodologies publication-title: Parasit Vectors doi: 10.1186/1756-3305-5-287 – volume-title: OECD Series on Principles of Good Laboratory Practice (GLP) and Compliance Monitoring year: 1998 ident: b33 – volume: 37 start-page: 593 year: 1947 ident: b1 article-title: The excitant and repellent effects on mosquitos of sub-lethal contacts with DDT publication-title: Bull Entomol Res doi: 10.1017/S0007485300030091 – volume: 47 start-page: 13 year: 1962 ident: b45 article-title: Age-grouping methods in Diptera of medical importance with special reference to some vectors of malaria publication-title: Monogr Ser World Health Organ – volume: 72 start-page: 3 year: 2002 ident: b49 article-title: Vector incrimination and entomological inoculation rates publication-title: Methods Mol Med – volume-title: Residual Transmission of Malaria: An Old Issue for New Approaches. Anonymous Anopheles Mosquitoes - New Insights into Malaria Vectors year: 2013 ident: b25 – volume: 377 start-page: 465 year: 2017 ident: b65 article-title: Evidence for health decision making–beyond randomized, controlled trials publication-title: N Engl J Med doi: 10.1056/NEJMra1614394 – volume: 16 start-page: 230 year: 2017 ident: b48 article-title: Fast and robust single PCR for Plasmodium sporozoite detection in mosquitoes using the cytochrome oxidase I gene publication-title: Malar J doi: 10.1186/s12936-017-1881-1 – volume: 16 start-page: 265 year: 2017 ident: b26 article-title: Multiple entries and exits and other complex human patterns of insecticide-treated net use: a possible contributor to residual malaria transmission? publication-title: Malar J doi: 10.1186/s12936-017-1918-5 – volume: 15 start-page: 192 year: 2016 ident: b47 article-title: Behaviour and molecular identification of Anopheles malaria vectors in jayapura district, Papua province, Indonesia publication-title: Malar J doi: 10.1186/s12936-016-1234-5 – volume: 14 start-page: e1002380 year: 2016 ident: b30 article-title: Tools and strategies for malaria control and elimination: what do we need to achieve a grand convergence in malaria? publication-title: PLoS Biol doi: 10.1371/journal.pbio.1002380 – volume: 13 start-page: 131 year: 2014 ident: b11 article-title: An experimental hut study to quantify the effect of DDT and airborne pyrethroids on entomological parameters of malaria transmission publication-title: Malar J doi: 10.1186/1475-2875-13-131 – volume-title: Conventional New Chemical Registration Decisions - Completed FY 2018 year: 2018 ident: b13 – volume: 50 start-page: 53 year: 2005 ident: b24 article-title: Mosquito behavior and vector control publication-title: Annu Rev Entomol doi: 10.1146/annurev.ento.50.071803.130439 – volume: 21 start-page: 13 year: 2010 ident: b53 article-title: The hazards of hazard ratios publication-title: Epidemiology doi: 10.1097/EDE.0b013e3181c1ea43 – start-page: 408 volume-title: Modelling Binary Data year: 2002 ident: b58 doi: 10.1201/b16654 – volume-title: E6(R2) Good Clinical Practice: Integrated Addendum to ICH E6(R1) year: 2018 ident: b32 – start-page: 33 volume-title: Microscopy for the Detection, Identification and Quantification of Malaria Parasites on Stained Thick and Thin Blood Films in Research Settings year: 2015 ident: b43 – volume-title: Global Vector Control Response 2017–2030 year: 2017 ident: b23 – volume: 13 start-page: 61 year: 1982 ident: b57 article-title: Discrete-time methods for the analysis of event histories publication-title: Sociological Methodol doi: 10.2307/270718 – volume: 31 start-page: 380 year: 2015 ident: b66 article-title: Evidence-based vector control? Improving the quality of vector control trials publication-title: Trends Parasitol doi: 10.1016/j.pt.2015.04.015 – volume: 91 start-page: 854 year: 2014 ident: b38 article-title: Comparison of quantitative and qualitative tests for glucose-6-phosphate dehydrogenase deficiency publication-title: Am J Trop Med Hyg doi: 10.4269/ajtmh.14-0194 – volume-title: 2010 Population Census - Indonesia year: 2010 ident: b34 – start-page: 173 volume-title: Advances in Parasitology year: 2013 ident: b35 article-title: The distribution and bionomics of Anopheles malaria vector mosquitoes in Indonesia – ident: b68 – volume-title: Malaria Control in Humanitarian Emergencies – An Inter-Agency Field Handbook year: 2013 ident: b28 – volume: 5 start-page: 17952 year: 2015 ident: b46 article-title: Unexpected diversity of Anopheles species in eastern Zambia: implications for evaluating vector behavior and interventions using molecular tools publication-title: Sci Rep doi: 10.1038/srep17952 – start-page: 462 volume-title: The Statistical Analysis of Failure Time Data year: 2011 ident: b56 – volume-title: Innovative Repellents for Disease-Carrying Mosquitoes ident: b70 – volume-title: Crude Birth and Death Rate Data by Country year: 2015 ident: b67 – volume: 72 start-page: 13 year: 2002 ident: b60 article-title: Epidemiological measures of risk of malaria publication-title: Methods Mol Med – volume-title: The Evaluation Process for Vector Control Products year: 2017 ident: b16 – volume: 2 start-page: e716 year: 2007 ident: b12 article-title: A new classification system for the actions of IRS chemicals traditionally used for malaria control publication-title: PLoS One doi: 10.1371/journal.pone.0000716 – volume: 53 start-page: 134 year: 1960 ident: b4 article-title: The designation of chemicals in terms of the responses they elicit from insects publication-title: J Econ Entomol doi: 10.1093/jee/53.1.134 – volume-title: Guidelines for Efficacy Testing of Spatial Repellents year: 2013 ident: b7 – volume: 15 start-page: 128 year: 2016 ident: b42 article-title: Human malaria diagnosis using a single-step direct-PCR based on the Plasmodium cytochrome oxidase III gene publication-title: Malar J doi: 10.1186/s12936-016-1185-x – volume: 2 start-page: CD011595 year: 2018 ident: b17 article-title: Mosquito repellents for malaria prevention publication-title: Cochrane Database Syst Rev – volume: 200 start-page: 860 year: 1963 ident: b3 article-title: Deterrent effect of insecticides on malaria vectors publication-title: Nature doi: 10.1038/200860a0 – volume-title: Transfluthrin year: 2016 ident: b40 – volume: 30 start-page: 1 year: 2009 ident: b62 article-title: Adaptive designs for randomized trials in public health publication-title: Annu Rev Public Health doi: 10.1146/annurev.publhealth.031308.100223 – volume: 2 start-page: CD000363 year: 1998 ident: b69 article-title: Insecticide-treated bed nets and curtains for preventing malaria publication-title: Cochrane Database Syst Rev – volume: 10 start-page: 222 year: 2011 ident: b37 article-title: Statistical methodology for the evaluation of vaccine efficacy in a phase III multi-centre trial of the RTS, S/AS01 malaria vaccine in African children publication-title: Malar J doi: 10.1186/1475-2875-10-222 – volume: 48 start-page: 2787 year: 2004 ident: b52 article-title: Hazard ratio in clinical trials publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.48.8.2787-2792.2004 – volume: 11 start-page: 5 year: 2011 ident: b39 article-title: Hemoglobin estimation by the HemoCue® portable hemoglobin photometer in a resource poor setting publication-title: BMC Clin Pathol doi: 10.1186/1472-6890-11-5 – start-page: 62 volume-title: How to Design Vector Control Efficacy Trials. Guidance on Phase III Vector Control Field Trial Design year: 2017 ident: b20 – start-page: 495 volume-title: Insect Repellents: Principles, Methods, and Uses year: 2006 ident: b15 doi: 10.1201/9781420006650 – volume: 13 start-page: 208 year: 2014 ident: b18 article-title: A household randomized, controlled trial of the efficacy of 0.03% transfluthrin coils alone and in combination with long-lasting insecticidal nets on the incidence of Plasmodium falciparum and Plasmodium vivax malaria in western Yunnan province, China publication-title: Malar J doi: 10.1186/1475-2875-13-208 – volume: 102 start-page: 2056 year: 2009 ident: b5 article-title: Designation of chemicals in terms of the locomotor responses they elicit from insects: an update of Dethier et al. (1960) publication-title: J Econ Entomol doi: 10.1603/029.102.0606 – volume: 25 start-page: 48 year: 2000 ident: b6 article-title: A probability model of vector behavior: effects of DDT repellency, irritancy, and toxicity in malaria control publication-title: J Vector Ecol – reference: 33069263 - Am J Trop Med Hyg. 2020 Nov;103(5):2151 |
| SSID | ssj0018211 |
| Score | 2.5222914 |
| Snippet | A cluster-randomized, double-blinded, placebo-controlled trial was conducted to estimate the protective efficacy (PE) of a spatial repellent (SR) against... |
| SourceID | pubmedcentral proquest pubmed crossref |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 344 |
| SubjectTerms | Child, Preschool Cyclopropanes - administration & dosage Double-Blind Method Female Fluorobenzenes - administration & dosage Households Housing Humans Indonesia Infant Infections Insect Repellents Insecticides - administration & dosage Malaria Malaria - prevention & control Male Mosquito Control Mosquito Vectors |
| Title | Efficacy of a Spatial Repellent for Control of Malaria in Indonesia: A Cluster-Randomized Controlled Trial |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/32431275 https://www.proquest.com/docview/2424116159 https://www.proquest.com/docview/2405306306 https://pubmed.ncbi.nlm.nih.gov/PMC7356406 |
| Volume | 103 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3db9MwELfKkBAvaHyubCAjIV5GRtIkTsPbBB0b2oYEqdS3yEkc6tKmVZs8tH8Ify93duK265AGL1Hk2Pnw_XL22Xe_I-Stxx3hMr9jceFklucLZvGuyC0YW1goPA5TBIwdvrpm533v68AftFq_N7yWqjI5SVe3xpX8j1ShDOSKUbL_IFlzUyiAc5AvHEHCcLyTjHvI_4D52lWQI2YXloorH3dUFOnSdI4hfcoXXbm6gBkrOS5xXGASD7GQvI5MH1dImGB951A-kStc9tXtxnAa4adszmKjdThKsck9AQ1mSujNjr3amhguf4L-MAD6seT5vMoyTV7wWRp0QgfqNZ5qJDEAYr0XtFIuBxeLCZfj496v6WzOl7Ispmu9jqEPeudKFJk8Bn0qN9czwHhtfF8bFewFzAIjTu91i1vKGr1tuzsA1VrY1ZSSN0cHjNrFoW9UToYnGLvla_7qbRbu62_xWf_yMo56g-geud8B8wMzY3wZGNchMMlUXmfzVpq7FW__Yevm23OdHQPmph_uxsQm2iePaouEnmp4PSYtUTwhD65qCT4lowZldJpTTmuUUYMyCiijNVqwSo0yKgtqUPaRntJdjNE1xqjC2DPSP-tFn86tOkOHlcLEr0Qi2rAbZm6asG5qo3EfJEzkguVB6gSMO6yT29zDeGXuQY08CVjAmA2N8qCT2O5zslfAixwQyjI_7QbCQUI4z85DLroCbBcwMDKM8nXb5H3Tl3Fa09djFpVxDGYsdn2suj52whi7vk3emeozzdvyt4pHjWDi-odZxBgz5aAtFLbJG3MZFC_upvFCTCusA-MXMtaxNnmh5WieBFaKi5kT2iTYkrCpgKTu21cKOVTk7oHrw_ezl3d47iF5uP6BjsheOa_EK5gil8lrhdc_4QLAGg |
| linkProvider | Geneva Foundation for Medical Education and Research |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+of+a+Spatial+Repellent+for+Control+of+Malaria+in+Indonesia%3A+A+Cluster-Randomized+Controlled+Trial&rft.jtitle=The+American+journal+of+tropical+medicine+and+hygiene&rft.au=Syafruddin%2C+Din&rft.au=Asih%2C+Puji+B+S&rft.au=Rozi%2C+Ismail+Ekoprayitno&rft.au=Permana%2C+Dendi+Hadi&rft.date=2020-07-01&rft.issn=1476-1645&rft.eissn=1476-1645&rft.volume=103&rft.issue=1&rft.spage=344&rft_id=info:doi/10.4269%2Fajtmh.19-0554&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9637&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9637&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9637&client=summon |