Carcinogenesis of Helicobacter pylori

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 133; no. 2; p. 659
• Main Authors: Correa, Pelayo, Houghton, Jeanmarie
• Format: Journal Article
• Language: English
• Published: United States 01.08.2007
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Anticarcinogenic Agents - pharmacology; Anticarcinogenic Agents - therapeutic use; Antioxidants - pharmacology; Antioxidants - therapeutic use; Bone Marrow Cells - microbiology; Bone Marrow Cells - pathology; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic - drug effects; Cell Transformation, Neoplastic - metabolism; Cell Transformation, Neoplastic - pathology; Disease Models, Animal; Disease Progression; Gastric Mucosa - drug effects; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Helicobacter Infections - complications; Helicobacter Infections - drug therapy; Helicobacter Infections - metabolism; Helicobacter Infections - microbiology; Helicobacter Infections - pathology; Helicobacter pylori; Humans; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells - microbiology; Neoplastic Stem Cells - pathology; Precancerous Conditions - metabolism; Precancerous Conditions - microbiology; Precancerous Conditions - pathology; Precancerous Conditions - prevention & control; Signal Transduction; Stomach Neoplasms - metabolism; Stomach Neoplasms - microbiology; Stomach Neoplasms - pathology; Stomach Neoplasms - prevention & control

Helicobacter infection is the leading cause of gastric cancer worldwide. Infection with this ubiquitous bacterium incites a chronic active immune response that persists for the life of the host, in the absence of antibiotic-induced eradication. It is the combination of bacterial factors, environment...