Randomized Trial of Radiation Therapy With Weekly Cisplatin or Cetuximab in Low-Risk HPV-Associated Oropharyngeal Cancer (TROG 12.01) – A Trans-Tasman Radiation Oncology Group Study

• Published in: International journal of radiation oncology, biology, physics Vol. 111; no. 4; pp. 876 - 886
• Main Authors: Rischin, Danny, King, Madeleine, Kenny, Lizbeth, Porceddu, Sandro, Wratten, Christopher, Macann, Andrew, Jackson, James E., Bressel, Mathias, Herschtal, Alan, Fisher, Richard, Fua, Tsien, Lin, Charles, Liu, Chen, Hughes, Brett G.M., McGrath, Margaret, McDowell, Lachlan, Corry, June
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.11.2021
• Subjects: Antineoplastic Combined Chemotherapy Protocols; Cetuximab; Chemoradiotherapy - adverse effects; Cisplatin; Head and Neck Neoplasms; Humans; Oropharyngeal Neoplasms - therapy; Overtreatment; Papillomavirus Infections - complications; Squamous Cell Carcinoma of Head and Neck

The excellent prognosis of patients with low-risk human papillomavirus (HPV)- associated oropharyngeal squamous cell carcinoma has led to concerns about overtreatment and excessive toxicity with radiation therapy and cisplatin, leading to interest in de-intensification trials. We investigated whethe...