The effects of CACNA1C gene polymorphism on prefrontal cortex in both schizophrenia patients and healthy controls

• Published in: Schizophrenia research Vol. 204; pp. 193 - 200
• Main Authors: Zhang, Zhifang, Wang, Yanyan, Zhang, Qiumei, Zhao, Wan, Chen, Xiongying, Zhai, Jinguo, Chen, Min, Du, Boqi, Deng, Xiaoxiang, Ji, Feng, Wang, Chuanyue, Xiang, Yutao, Li, Dawei, Wu, Hongjie, Dong, Qi, Chen, Chuansheng, Li, Jun
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2019
• Subjects: Adult; CACNA1C gene; Calcium Channels, L-Type - genetics; Cognitive function; Executive Function - physiology; Female; fMRI; fNIRS; Functional Neuroimaging; Humans; Inferior frontal gyrus; Magnetic Resonance Imaging; Male; Polymorphism, Single Nucleotide; Prefrontal Cortex - diagnostic imaging; Prefrontal Cortex - physiopathology; Schizophrenia - diagnostic imaging; Schizophrenia - genetics; Schizophrenia - physiopathology; Spectroscopy, Near-Infrared; Young Adult; fMRI; fNIRS; CACNA1C gene; Cognitive function; Inferior frontal gyrus

CACNA1C gene polymorphism rs2007044 has been reported to be associated with schizophrenia, but its underlying brain mechanism is not clear. First, we conducted an exploratory functional magnetic resonance imaging (fMRI) study using an N-BACK task and a Stroop task in 194 subjects (55 schizophrenia p...