Demineralized bone matrix fibers formable as general and custom 3D printed mold-based implants for promoting bone regeneration

• Published in: Biofabrication Vol. 8; no. 3; p. 035007
• Main Authors: Rodriguez, Rudy U, Kemper, Nathan, Breathwaite, Erick, Dutta, Sucharita M, Huber, Alexander, Murchison, Angela, Chen, Silvia, Hsu, Erin L, Hsu, Wellington K, Francis, Michael P
• Format: Journal Article
• Language: English
• Published: England IOP Publishing 26.07.2016
• Subjects: 3D printing; allograft; Animals; Bone and Bones - pathology; Bone and Bones - physiology; Bone Matrix - chemistry; Bone Matrix - metabolism; Bone Morphogenetic Proteins - metabolism; bone regeneration; Bone Regeneration - drug effects; Bone Substitutes - chemistry; Bone Substitutes - pharmacology; Bone Substitutes - therapeutic use; Cell Differentiation - drug effects; Cell Line; computer aided design and modeling; Computer-Aided Design; demineralized bone matrix; Female; Humans; Insulin-Like Growth Factor I - metabolism; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Mice; Mice, Nude; Minimally Invasive Surgical Procedures; Osteogenesis - drug effects; Printing, Three-Dimensional; Prostheses and Implants; Rats; Rats, Sprague-Dawley; Spine - pathology; Spine - surgery; stem cell; Surface Properties; Tissue Engineering - methods; Tissue Scaffolds - chemistry

Introduction. Bone repair frequently requires time-consuming implant construction, particularly when using un-formed implants with poor handling properties. We therefore developed osteoinductive, micro-fibrous surface patterned demineralized bone matrix (DBM) fibers for engineering both defect-match...