Synthesis and preclinical evaluation of [11C]uPSEM792 for PSAM4-GlyR based chemogenetics

• Published in: Scientific reports Vol. 14; no. 1; pp. 1886 - 13
• Main Authors: Nerella, Sridhar Goud, Telu, Sanjay, Liow, Jeih-San, Jenkins, Madeline D., Zoghbi, Sami S., Gomez, Juan L., Michaelides, Michael, Eldridge, Mark A. G., Richmond, Barry J., Innis, Robert B., Pike, Victor W.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.01.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378/3920; 639/638/903; Blood-brain barrier; Humanities and Social Sciences; Iodomethane; Ligands; Mental disorders; multidisciplinary; Positron emission tomography; Radioactivity; Science; Science (multidisciplinary); Serotonin S3 receptors

Chemogenetic tools are designed to control neuronal signaling. These tools have the potential to contribute to the understanding of neuropsychiatric disorders and to the development of new treatments. One such chemogenetic technology comprises modified Pharmacologically Selective Actuator Modules (P...