Racemic and chiral sulfoxides as potential prodrugs of 4-pyrone COX-2 inhibitors
The enantiomeric synthesis and profiling of sulfoxide-based prodrugs of potent COX-2 inhibitors discovered at Almirall are reported. The preparation of the sulfoxide analogues 7, 8, and 9 and their enantiomerically pure forms is discussed as well as their ability to act as prodrugs of the potent and...
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Published in | Bioorganic & medicinal chemistry letters Vol. 16; no. 13; pp. 3605 - 3608 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
01.07.2006
Elsevier |
Subjects | |
Online Access | Get full text |
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